Anaesthesia:舒芬太尼对老年患者脑电双频指数的影响

2018-03-11 李华宇 “罂粟花”微信号

本研究的目的是评估异丙酚麻醉诱导过程中加入舒芬太尼对老年患者(≥65岁)脑电双频指数的影响。

背景与目的:本研究的目的是评估异丙酚麻醉诱导过程中加入舒芬太尼对老年患者(≥65岁)脑电双频指数的影响。

方  法:患者被随机分配为接受舒芬太尼靶控输注组(效应室浓度为0.3 ng·mL-1)或给予等量的安慰剂组,随后异丙酚靶控诱导(初始效应室浓度为0.5 lg.ml-1;逐步增加至0.5 lg·ml-1)直到意识丧失,即定义为观察员评估的警觉/镇静评分<2。

结  果:71名患者(舒芬太尼组35名,安慰剂组36名)完成了研究。平均年龄(标准差)为72.3岁(5.8岁),其中41%为女性。在意识丧失时,平均脑电双频指数值(标准差)舒芬太尼组为75(8.6),安慰剂组为70(8),平均差异值-5(95%置信区间为-8.9~-1.1),p=0.013。研究后分析表明,仅男性之间的差异非常显着(平均差异值为-7.3(-11.8 ~-2.6),P=0.003)。

结  论:舒芬太尼与异丙酚联合诱导会导致老年患者意识丧失时的脑电双频指数增高。

原始出处:

de Valence T,et al.Effect of sufentanil on bispectral index in the elderly.Anaesthesia. 2018 Feb;73(2):216-222.

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    2018-04-21 AspirantSuo
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    2018-03-13 xue8602
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    2018-03-13 skhzy