Int J Pediatr Otorhinolaryngol:感官听力损失和具有新生儿重症监护病房经历儿童音调听力测定变化研究

2017-10-12 AlexYang MedSci原创

新生儿重症监护室(NICU)的新生儿具有高风险的感官听力损失(SNHL)。因此,跟踪调查研究来进行早期的诊断和干预是必要的。最近,有研究人员阐释了在为期20年的跟踪调查期间的不同阶段,SNHL的特性和变化情况。研究人员分析了SNHL发展中的风险因子。听力测定检查包括:脑干听力激发电位(BAEP)和瞬态诱发性耳声发射(TEOAE)。另外,研究人员还在5岁、10岁、15岁和20岁生日时进行了音调听力测

新生儿重症监护室(NICU)的新生儿具有高风险的感官听力损失(SNHL)。因此,跟踪调查研究来进行早期的诊断和干预是必要的。最近,有研究人员阐释了在为期20年的跟踪调查期间的不同阶段,SNHL的特性和变化情况。研究人员分析了SNHL发展中的风险因子。听力测定检查包括:脑干听力激发电位(BAEP)和瞬态诱发性耳声发射(TEOAE)。另外,研究人员还在5岁、10岁、15岁和20岁生日时进行了音调听力测定(125到8000Hz)和鼓室导抗测试。

研究发现,65%的案例表现出了双边BAEP缺失。在5岁时,重度SNHL所占比例最高(42.5%),其他依次是中度(22.5%)和永久(20%),在所有的案例中,SNHL在高频率的优势损伤中是对称的。换血疗法与更高程度的SNHL相关(OR = 6.00, CI = 1.11-32.28, p < 0.02)。在55%的案例中,SNHL保持稳定,而在40%的案例中,SNHL不断的发展。在研究末期,有6个案例总中度损失发展到了重度水平,7个案例从重度发展到了永久性损失。

最后,研究人员指出,40%的从NICU离开且具有SNHL的新生儿会表现出听力损失的发展和恶化。换血疗法与更高等级的SNHL相关。另外对患有SNHL的NICU新生儿进行长期的听力测定跟踪调查是值得的。

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    2017-12-04 feather89
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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=252461, encodeId=0d3425246199, content=学习了新知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Fri Oct 13 08:05:00 CST 2017, time=2017-10-13, status=1, ipAttribution=)]
    2017-10-18 三生有幸9135

    学习一下谢谢分享

    0

  7. 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    2017-10-14 ysjykql
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    2017-10-14 bioon6
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    2017-10-13 Y—xianghai

    学习了新知识

    0

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最近,有研究人员在患有听力损失的学龄前儿童与正常听力学龄前儿童之间比较了行为问题的流行程度。研究是一个代表性的研究,地点在一个高等教育中心。参与的儿童包括39名具有正常听力的儿童,年龄在2-5岁,以及29名助听器(HA)使用的儿童和21名耳蜗移植儿童。研究人员获得了受试者的人口统计学信息和精神健康历史信息,并且对儿童行为和语言发育进行了评估。研究发现,在所有小组中,种族分布、社会经济地位、保险状况

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最近,有研究人员比较了学龄前儿童中,患有听力损失和不患有听力损失的紧急读写能力,研究时间持续了6个月。参与者包括了19名患有听力损失的而儿童和14名正常听力的儿童。患有听力损失的儿童使用放大器和口语。参与者在6个月调查期间完成了2次的口语、语言处理和文字知识测试。研究人员还利用一系列方差的重复测量分析比较了不同小组之间的变化。研究发现,时间的主要影响涉及到了所有变量,但不包括语言处理。小组之间的主

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听力损失是一种常见的疾病,通常通过全身用药和/或者鼓膜内注射皮质类固醇来进行治疗。最近,有研究人员比较了鼓膜内注射地塞米松以及与透明质酸结合注射时,对突发性感官听力损失病人的治疗效应。在该次临床实践中,40名病人被随机分配到2个组;在第一个小组中,20名病人接受2.4毫克鼓膜内地塞米松注射,然而在第二小组中,病人接受2.4毫克地塞米松和2毫克透明质酸组合注射。两个小组的病人每隔一天进行一次注射,总

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常染色体隐性遗传非综合征听力损失是一种异质性疾病并且是最为流行的人类遗传感官缺陷疾病。最近,有研究人员调查了在摩洛哥病人中感官听力损失的遗传方面起因,并且在患有永久性耳聋的两个摩洛哥家庭中呈现了全外显子组测序(WES)在鉴定候选基因中的重要性。研究人员在排除了之前在摩洛哥耳聋病人中报道过的突变后,研究人员进行了全外显子组测序和并利用Sanger测序来确定这些基因中的变异。研究揭示了c.113_11

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最近,有研究人员在患有临床零星耳聋的病人中,利用DNA芯片技术筛选了相关遗传基因,并且评估了临床检测的应用价值。研究人员提取了病人静脉血的DNA,并应用于PCR分析,还在万级洁净室内进行了核酸杂交分析。还对中国人群中常见的4个耳聋基因的9个突变位点进行了测试。研究发现,在24名病人中,检测到了7个具有变异的案例,阳性率为29.17%。这些包括4个具有GJB2基因变异的案例(16.67%),其中的1