Circulation:血压<140/90mmHg的成年人心血管疾病的发病风险不容轻视

2017-10-12 吴星 环球医学

2017年8月,发表在《Circulation》的一项由美国科学家进行的研究考察了血压<140/90mmHg的成年人心血管疾病(CVD)的发病情况。

2017年8月,发表在《Circulation》的一项由美国科学家进行的研究考察了血压<140/90mmHg的成年人心血管疾病(CVD)的发病情况。

背景:2000年以前的数据表明,在美国,多数CVD的发病都是在收缩压和舒张压(SBP/DBP)≥140/90mmHg的成人中发生的。在过去的几十年里,血压已经降低,高血压控制已经得到改善。

方法:研究者在以下3个美国当代队列的汇总分析中评估了SBP/DBP<140/90mmHg的成人的CVD事件百分比:REGARDS研究(卒中的地理和种族差异原因)、MESA(动脉粥样硬化的多种族研究)、JHS(杰克逊心脏研究)(总共31856人;REGARDS为21208人,MESA为6779人,JHS为3869人)。REGARDS于2003~2007年进行了基线研究访问,MESA于2000~2002年,JHS为2000~2004年。受过培训的员工使用标准化的方法测量了血压。抗高血压药物的使用是自我报告的。首要结局为CVD发病,其定义为首次发生致命性或非致命性卒中、非致命性心肌梗死、致命性冠心病或心衰。每个研究都判断了事件。

结果:平均随访7.7年,2584名参与者CVD发病。总体来说,63.0%(95% CI,54.9~71.1)的事件发生在SBP/DBP<140/90mmHg的参与者中,58.4%(47.7~69.2)和68.1%(60.1~76.0)分别服用和不服用抗高血压药物。多数事件发生在SBP/DBP<140/90mmHg的患者中,分布如下:<65岁(66.7%;60.5~73.0)和≥65岁(60.3%;51.0~69.5)、女性(61.4%;49.9~72.9)和男性(63.8%;58.4~69.1)、白人(68.7%;66.1~71.3)、黑人(59.0%;49.5~68.6)、西班牙裔(52.7%;45.1~60.4)、华裔(58.5%;45.2~71.8)。服用抗高血压药且SBP/DBP<140/90mmHg的参与者中,76.6%(75.8~77.5)符合他汀治疗,但是仅有33.2%(32.1~34.3)服用了他汀,19.5%(18.5~20.5)符合SPRINT(收缩压干预试验)的入组标准,可从120mmHg的SBP目标中获益。

结论:虽然较高的血压与CVD风险增加相关,但是当前情况下,多数CVD事件发生在SBP/DBP<140/90mmHg的美国成人中。虽然需要考虑绝对风险和成本效果,但是也需要测量处于较高CVD风险且SBP/DBP<140/90mmHg者的额外CVD风险降低。

原始出处:

Tajeu GS, Booth JN 3rd, Colantonio LD,et al. Incident Cardiovascular Disease Among Adults With Blood Pressure <140/90 mmHg. Circulation. 2017 Aug 29;136(9):798-812. doi: 10.1161/CIRCULATIONAHA.117.027362. Epub 2017 Jun 20.

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    2017-10-29 topnew

    看来理想血压就是一百二十七十以下.

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=256911, encodeId=9b7825691199, content=看来理想血压就是一百二十七十以下., beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6ef781002, createdName=topnew, createdTime=Sun Oct 29 09:44:36 CST 2017, time=2017-10-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1498299, encodeId=be1114982992f, content=<a href='/topic/show?id=bb6f89e145a' target=_blank style='color:#2F92EE;'>#血管疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89714, encryptionId=bb6f89e145a, topicName=血管疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ccb99370406, createdName=andy2090, createdTime=Sat Oct 14 05:32:00 CST 2017, time=2017-10-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=252564, encodeId=6df4252564d2, content=很好的文章.可以学到很多东西, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160914/IMG57D82E721DB581755.jpg, createdBy=4fc81933929, createdName=明天会更好!, createdTime=Fri Oct 13 13:53:38 CST 2017, time=2017-10-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=252283, encodeId=df66252283c4, content=henhao, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NcXNhUvfhzd2VdicMnaLeK2Im5gKx4Ucxd8Bwu6S7RG0uILBFQx5HTW2bU4VricDYlQqN20ibASSMYAeGrZrrTpy2Q/0, createdBy=7dcf1938111, createdName=1e0e5a1fm42(暂无匿称), createdTime=Thu Oct 12 19:18:13 CST 2017, time=2017-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=252263, encodeId=38ae25226360, content=收藏, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/mzZkwf53jx0oribz8WkmVTPTSib4iaRMXz6nkEOaqWPjgyYWQoLa8J2WCicWvb8SrhhZz5sgUcwmQnMQ1lJcA7Fhxg/0, createdBy=9b182084756, createdName=yunger, createdTime=Thu Oct 12 18:30:18 CST 2017, time=2017-10-12, status=1, ipAttribution=)]
  3. [GetPortalCommentsPageByObjectIdResponse(id=256911, encodeId=9b7825691199, content=看来理想血压就是一百二十七十以下., beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6ef781002, createdName=topnew, createdTime=Sun Oct 29 09:44:36 CST 2017, time=2017-10-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1498299, encodeId=be1114982992f, content=<a href='/topic/show?id=bb6f89e145a' target=_blank style='color:#2F92EE;'>#血管疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89714, encryptionId=bb6f89e145a, topicName=血管疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ccb99370406, createdName=andy2090, createdTime=Sat Oct 14 05:32:00 CST 2017, time=2017-10-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=252564, encodeId=6df4252564d2, content=很好的文章.可以学到很多东西, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160914/IMG57D82E721DB581755.jpg, createdBy=4fc81933929, createdName=明天会更好!, createdTime=Fri Oct 13 13:53:38 CST 2017, time=2017-10-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=252283, encodeId=df66252283c4, content=henhao, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NcXNhUvfhzd2VdicMnaLeK2Im5gKx4Ucxd8Bwu6S7RG0uILBFQx5HTW2bU4VricDYlQqN20ibASSMYAeGrZrrTpy2Q/0, createdBy=7dcf1938111, createdName=1e0e5a1fm42(暂无匿称), createdTime=Thu Oct 12 19:18:13 CST 2017, time=2017-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=252263, encodeId=38ae25226360, content=收藏, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/mzZkwf53jx0oribz8WkmVTPTSib4iaRMXz6nkEOaqWPjgyYWQoLa8J2WCicWvb8SrhhZz5sgUcwmQnMQ1lJcA7Fhxg/0, createdBy=9b182084756, createdName=yunger, createdTime=Thu Oct 12 18:30:18 CST 2017, time=2017-10-12, status=1, ipAttribution=)]
    2017-10-13 明天会更好!

    很好的文章.可以学到很多东西

    0

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    2017-10-12 1e0e5a1fm42(暂无匿称)

    henhao

    0

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    2017-10-12 yunger

    收藏

    0

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