JCEM:胰腺癌风险随空腹血糖水平升高而增加

2019-07-25 xing.T MedSci原创

由此可见,即使在具有正常血糖水平的个体中,随着空腹血糖水平升高,胰​​腺癌的累积发病率显著增加。

目前尚不清楚胰腺癌的风险是否因血糖水平而异。近日,内分泌和代谢性疾病领域权威杂志Journal of Clinical Endocrinology & Metabolism上发表了一篇研究文章,该研究旨在使用在韩国进行的前瞻性收集的全国人口队列数据,来明确空腹血糖水平与胰腺癌风险之间的关联。

在2009年至2015年期间,研究人员使用了国家健康保险服务(NHIS)索赔数据库和预防性健康检查数据,并评估了2009年至2013年期间参与预防性健康检查的总计2540万名患者根据空腹血糖水平的胰腺癌发病率。根据空腹血糖水平分组如下:1)正常低水平(<90 mg/dL)、2)正常高水平(90-99 mg/dL)、3)糖尿病前期1级(100-109 mg/dl)、4)糖尿病前期2级(110-125 mg/dl)、5)糖尿病(≥126mg/dL)和6)接受抗糖尿病药物治疗,并计算各组胰腺癌的累积发病率。

5年累积发病率(每100000人)如下:1)正常低水平=32; 2)正常高水平=41; 3)糖尿病前期1级=50; 4)糖尿病前期2级=64; 5)糖尿病=75; 6)抗糖尿病药物治疗=121。随着空腹血糖水平的升高,胰腺癌的风险持续增加(P<0.0001)。即使在调整了年龄、性别、吸烟、饮酒、运动、体重指数和糖尿病病程后,胰腺癌的发病率也随着空腹血糖水平的增加而显著增加(P<0.0001)。

由此可见,即使在具有正常血糖水平的个体中,随着空腹血糖水平升高,胰​​腺癌的累积发病率显著增加。 

原始出处:

Dong-Hoe Koo,et al.The Incremental Risk of Pancreatic Cancer According to Fasting Glucose Levels: Nationwide Population-Based Cohort Study.J Clin Endocrinol Metab. 2019.https://doi.org/10.1210/jc.2019-00033

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    2019-10-05 smallant2015
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    2019-11-23 achengzhao
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    2020-05-24 sjq027
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