Stroke:利用CTP准确评估急性缺血性脑卒中侧支循环功能

2020-07-11 shaosai MedSci原创

本研究旨在利用CT灌注成像建立和验证评估急性缺血性脑卒中患者侧支循环的最佳测量方法。

背景与目的

本研究旨在利用CT灌注成像建立和验证评估急性缺血性脑卒中患者侧支循环的最佳测量方法。

方法

在第1步分析中(n=22),缺血性半球旁矢状面区域被分为6个软脑膜动脉区域并通过ROC曲线分析来获得最佳侧枝阈值;在第2步分析中(n=156),利用侧枝循环阈值来定义侧枝循环指数。在第2步分析中,比价CT灌注侧支循环指数与动态CTA侧支循环评分来预测临床预后。

结果

最佳侧枝循环阈值为延迟时间>6s(敏感性和特异性分别为88% 、92%)。CT灌注侧枝循环指数定义为延迟时间>6s/延迟时间>2s体积,显示与动态CTA侧枝循环评分具有显著相关性(相关系数为0.62; P<0.001),预测较高侧支循环功能的最佳截断值为31.8%(敏感性和特异性分别为83% 、86%)。在预测良好临床预后时,延迟时间侧支循环指数显示其与动态CTA的预测价值相似(ROC曲线下面积分别为0.78 [0.67-0.83] 、0.77 [0.69-0.84]; P<0.001)。

结论

CTP能够准确定量评价急性缺血性脑卒中侧支循环功能。

原始出处:

Lin L , Chen C , Tian H et al.Perfusion Computed Tomography Accurately Quantifies Collateral Flow After Acute Ischemic Stroke.DOI:10.1161/STROKEAHA.119.028284

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    2020-09-12 whlxd
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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200711/8cf1a2946fc14af2bc879ee50d546249/04951632b612493ab5278b090b1c095c.jpg, createdBy=be935399814, createdName=果m, createdTime=Sun Jul 12 00:30:28 CST 2020, time=2020-07-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=802535, encodeId=e0b780253588, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200711/8cf1a2946fc14af2bc879ee50d546249/04951632b612493ab5278b090b1c095c.jpg, createdBy=be935399814, createdName=果m, createdTime=Sat Jul 11 21:24:57 CST 2020, time=2020-07-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1026673, encodeId=ed8f10266e351, content=卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=健健, createdTime=Sat Jul 11 20:39:26 CST 2020, time=2020-07-11, status=1, ipAttribution=)]
    2020-10-29 ms5000001474831154

    ⊙∀⊙!

    0

  5. 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200711/8cf1a2946fc14af2bc879ee50d546249/04951632b612493ab5278b090b1c095c.jpg, createdBy=be935399814, createdName=果m, createdTime=Sun Jul 12 00:30:28 CST 2020, time=2020-07-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=802535, encodeId=e0b780253588, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200711/8cf1a2946fc14af2bc879ee50d546249/04951632b612493ab5278b090b1c095c.jpg, createdBy=be935399814, createdName=果m, createdTime=Sat Jul 11 21:24:57 CST 2020, time=2020-07-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1026673, encodeId=ed8f10266e351, content=卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=健健, createdTime=Sat Jul 11 20:39:26 CST 2020, time=2020-07-11, status=1, ipAttribution=)]
  6. [GetPortalCommentsPageByObjectIdResponse(id=1807145, encodeId=77bc180e14596, content=<a href='/topic/show?id=245de9378aa' target=_blank style='color:#2F92EE;'>#缺血性脑#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79378, encryptionId=245de9378aa, topicName=缺血性脑)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLGtr9t89oicQdQSIeKmOQic1weIWfibJ7H24XnT8ic9wiaUMTnXByenuwicOj8Jib42ibHXNptnuiaKthhiaVw/132, createdBy=ac342500190, createdName=ms7524819409032184, createdTime=Sat Apr 10 12:39:26 CST 2021, time=2021-04-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1647801, encodeId=d72d164e8014f, content=<a href='/topic/show?id=a0d954329f' target=_blank style='color:#2F92EE;'>#CTP#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, 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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=28595397568, createdName=ms5000001474831154, createdTime=Thu Oct 29 10:31:31 CST 2020, time=2020-10-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1259413, encodeId=9efd125941329, content=<a href='/topic/show?id=5679523e201' target=_blank style='color:#2F92EE;'>#急性缺血性脑卒中#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52372, encryptionId=5679523e201, topicName=急性缺血性脑卒中)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=智智灵药, createdTime=Mon Jul 13 08:39:26 CST 2020, time=2020-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1390667, encodeId=416b139066ed5, content=<a href='/topic/show?id=796e26955ce' target=_blank style='color:#2F92EE;'>#侧支循环#</a>, beContent=null, 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200711/8cf1a2946fc14af2bc879ee50d546249/04951632b612493ab5278b090b1c095c.jpg, createdBy=be935399814, createdName=果m, createdTime=Sun Jul 12 00:30:28 CST 2020, time=2020-07-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=802535, encodeId=e0b780253588, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200711/8cf1a2946fc14af2bc879ee50d546249/04951632b612493ab5278b090b1c095c.jpg, createdBy=be935399814, createdName=果m, createdTime=Sat Jul 11 21:24:57 CST 2020, time=2020-07-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1026673, encodeId=ed8f10266e351, content=卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!, beContent=null, objectType=article, channel=null, 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  7. [GetPortalCommentsPageByObjectIdResponse(id=1807145, encodeId=77bc180e14596, content=<a href='/topic/show?id=245de9378aa' target=_blank style='color:#2F92EE;'>#缺血性脑#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79378, encryptionId=245de9378aa, topicName=缺血性脑)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLGtr9t89oicQdQSIeKmOQic1weIWfibJ7H24XnT8ic9wiaUMTnXByenuwicOj8Jib42ibHXNptnuiaKthhiaVw/132, createdBy=ac342500190, createdName=ms7524819409032184, createdTime=Sat Apr 10 12:39:26 CST 2021, time=2021-04-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1647801, encodeId=d72d164e8014f, content=<a href='/topic/show?id=a0d954329f' target=_blank style='color:#2F92EE;'>#CTP#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200711/8cf1a2946fc14af2bc879ee50d546249/04951632b612493ab5278b090b1c095c.jpg, createdBy=be935399814, createdName=果m, createdTime=Sun Jul 12 00:30:28 CST 2020, time=2020-07-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=802535, encodeId=e0b780253588, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200711/8cf1a2946fc14af2bc879ee50d546249/04951632b612493ab5278b090b1c095c.jpg, createdBy=be935399814, createdName=果m, createdTime=Sat Jul 11 21:24:57 CST 2020, time=2020-07-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1026673, encodeId=ed8f10266e351, content=卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=健健, createdTime=Sat Jul 11 20:39:26 CST 2020, time=2020-07-11, status=1, ipAttribution=)]
    2020-07-12 13b4fb3am87暂无昵称

    学习了

    0

  8. 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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=28595397568, createdName=ms5000001474831154, createdTime=Thu Oct 29 10:31:31 CST 2020, time=2020-10-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1259413, encodeId=9efd125941329, content=<a href='/topic/show?id=5679523e201' target=_blank style='color:#2F92EE;'>#急性缺血性脑卒中#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52372, encryptionId=5679523e201, topicName=急性缺血性脑卒中)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=智智灵药, createdTime=Mon Jul 13 08:39:26 CST 2020, time=2020-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1390667, encodeId=416b139066ed5, content=<a href='/topic/show?id=796e26955ce' target=_blank style='color:#2F92EE;'>#侧支循环#</a>, beContent=null, 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200711/8cf1a2946fc14af2bc879ee50d546249/04951632b612493ab5278b090b1c095c.jpg, createdBy=be935399814, createdName=果m, createdTime=Sun Jul 12 00:30:28 CST 2020, time=2020-07-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=802535, encodeId=e0b780253588, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200711/8cf1a2946fc14af2bc879ee50d546249/04951632b612493ab5278b090b1c095c.jpg, createdBy=be935399814, createdName=果m, createdTime=Sat Jul 11 21:24:57 CST 2020, time=2020-07-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1026673, encodeId=ed8f10266e351, content=卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=健健, createdTime=Sat Jul 11 20:39:26 CST 2020, time=2020-07-11, status=1, ipAttribution=)]
    2020-07-12 果m

    学习

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=1807145, encodeId=77bc180e14596, content=<a href='/topic/show?id=245de9378aa' target=_blank style='color:#2F92EE;'>#缺血性脑#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79378, encryptionId=245de9378aa, topicName=缺血性脑)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLGtr9t89oicQdQSIeKmOQic1weIWfibJ7H24XnT8ic9wiaUMTnXByenuwicOj8Jib42ibHXNptnuiaKthhiaVw/132, createdBy=ac342500190, createdName=ms7524819409032184, createdTime=Sat Apr 10 12:39:26 CST 2021, time=2021-04-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1647801, encodeId=d72d164e8014f, content=<a href='/topic/show?id=a0d954329f' target=_blank style='color:#2F92EE;'>#CTP#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, 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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=28595397568, createdName=ms5000001474831154, createdTime=Thu Oct 29 10:31:31 CST 2020, time=2020-10-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1259413, encodeId=9efd125941329, content=<a href='/topic/show?id=5679523e201' target=_blank style='color:#2F92EE;'>#急性缺血性脑卒中#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52372, encryptionId=5679523e201, topicName=急性缺血性脑卒中)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=智智灵药, createdTime=Mon Jul 13 08:39:26 CST 2020, time=2020-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1390667, encodeId=416b139066ed5, content=<a href='/topic/show?id=796e26955ce' target=_blank style='color:#2F92EE;'>#侧支循环#</a>, beContent=null, 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200711/8cf1a2946fc14af2bc879ee50d546249/04951632b612493ab5278b090b1c095c.jpg, createdBy=be935399814, createdName=果m, createdTime=Sun Jul 12 00:30:28 CST 2020, time=2020-07-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=802535, encodeId=e0b780253588, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200711/8cf1a2946fc14af2bc879ee50d546249/04951632b612493ab5278b090b1c095c.jpg, createdBy=be935399814, createdName=果m, createdTime=Sat Jul 11 21:24:57 CST 2020, time=2020-07-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1026673, encodeId=ed8f10266e351, content=卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=健健, createdTime=Sat Jul 11 20:39:26 CST 2020, time=2020-07-11, status=1, ipAttribution=)]
    2020-07-11 果m

    学习

    0

  10. 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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=28595397568, createdName=ms5000001474831154, createdTime=Thu Oct 29 10:31:31 CST 2020, time=2020-10-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1259413, encodeId=9efd125941329, content=<a href='/topic/show?id=5679523e201' target=_blank style='color:#2F92EE;'>#急性缺血性脑卒中#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52372, encryptionId=5679523e201, topicName=急性缺血性脑卒中)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=智智灵药, createdTime=Mon Jul 13 08:39:26 CST 2020, time=2020-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1390667, encodeId=416b139066ed5, content=<a href='/topic/show?id=796e26955ce' target=_blank style='color:#2F92EE;'>#侧支循环#</a>, beContent=null, 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200711/8cf1a2946fc14af2bc879ee50d546249/04951632b612493ab5278b090b1c095c.jpg, createdBy=be935399814, createdName=果m, createdTime=Sun Jul 12 00:30:28 CST 2020, time=2020-07-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=802535, encodeId=e0b780253588, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200711/8cf1a2946fc14af2bc879ee50d546249/04951632b612493ab5278b090b1c095c.jpg, createdBy=be935399814, createdName=果m, createdTime=Sat Jul 11 21:24:57 CST 2020, time=2020-07-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1026673, encodeId=ed8f10266e351, content=卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=健健, createdTime=Sat Jul 11 20:39:26 CST 2020, time=2020-07-11, status=1, ipAttribution=)]
    2020-07-11 健健

    卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!

    0

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