JCC: MR在评估长期克罗恩病肠道炎症和狭窄中的作用

2019-05-07 不详 MedSci原创

克罗恩病[CD]是一种慢性肠道炎症,其经常出现纤维化狭窄。磁共振肠造影[MRE]是评估CD的重要诊断工具。本项研究的目的是评估长期CD患者的肠段出现炎症和狭窄疾病的患病率,并研究与临床因素的关系。

背景
克罗恩病[CD]是一种慢性肠道炎症,其经常出现纤维化狭窄。磁共振肠造影[MRE]是评估CD的重要诊断工具。本项研究的目的是评估长期CD患者的肠段出现炎症和狭窄疾病的患病率,并研究与临床因素的关系。

方法
研究人员对挪威东南部237名患有20年病史以上的CD患者进行了一项基于人群的队列随访分析; 用MRE检查95名患者,并计算磁性肠功能评分[MEGS]。我们在随访期间评估了患者的肠道炎症和狭窄。通过单变量回归分析检查MEGS和肠狭窄与临床变量的关联。

结果
在237例患者中,62例[65.3%]有活动性炎症,主要影响回肠末端; 根据MEGS,35名患者 [36.8%]有明显的炎症且与炎症生物标志物有关; 25名患者[26.3%]患有与年龄相关的狭窄疾病(优势比[OR] = 0.92),大多数狭窄患者接受手术治疗。

结论
本项研究表明长期的CD病史会导致大多数患者出现活动性炎症。大多数狭窄患者接受了手术治疗而没有出现疾病复发。

原始出处:

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    2019-07-07 wxl882001

    了解一下

    0

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    2019-05-19 wxl882001

    了解一下

    0

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    2019-05-12 wxl882001

    了解一下

    0

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磁共振肠造影[MRE]是评估克罗恩病回肠炎症的有效手段[CD]。本研究的目的是通过一个独特的回肠队列中的简单评分将粪便钙卫蛋白[FC]与MRE相关联,并进行长期随访,以判断粪便钙卫蛋白和磁共振成像之间关系及与手术或生物治疗之间的关联。