Int J Impot Res:早泄患者口服药物的安全性和效果评估

2019-05-06 AlexYang MedSci原创

尽管之前的研究已经调查了早泄(PE)患者口服药物的安全性和效果情况,但是其结果存在不一致的情况。因此,最近有研究人员在PE患者中综合的比较了口服药物的效果和一些相关的并发症。研究的元分析中总共包括了25个相关的研究。PE口服药物主要包括了羟色胺再吸收抑制剂(SSRIs)和磷酸二酯酶5型抑制剂。他们的结果成功的阐释了治疗PE口服药物在效果上的差异。IELT在4-6周的累积排名从最好到最差分别为SSR

尽管之前的研究已经调查了早泄(PE)患者口服药物的安全性和效果情况,但是其结果存在不一致的情况。因此,最近有研究人员在PE患者中综合的比较了口服药物的效果和一些相关的并发症。

研究的元分析中总共包括了25个相关的研究。PE口服药物主要包括了羟色胺再吸收抑制剂(SSRIs)和磷酸二酯酶5型抑制剂。他们的结果成功的阐释了治疗PE口服药物在效果上的差异。IELT在4-6周的累积排名从最好到最差分别为SSRIs+PDE5i、PDE5i和其他单独使用的SSRIs。另外,他们的元分析同样也表明了氟西汀20 mg、达泊西汀60 mg、PDE5i和SSRIs+PDE5i具有更高的临床相关并发症发生率,而其他的SSRIs单独使用具有相对更低的发生率。

最后,研究人员指出,他们的结果表明了PDE5i单独使用或者与SSRIs组合使用比SSRIs单独使用在口服药物治疗PE效果上更好。尽管如此,PDE5i的使用还存在副作用问题,包括肠或中枢神经系统并发症,这也妨碍了其成为一线的治疗药物。虽然出现了一些新的治疗选择,综合考虑之下SSRIs仍旧是治疗PE口服药物的首选。


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    2020-04-10 gdsun
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    2019-05-08 风铃826
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    2019-05-06 一个字-牛

    学习了谢谢分享

    0

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    2019-05-06 CHANGE

    疗效只是效果的众多方面之一,还要看对患者的获益,包括生活质量等因素共同决定效果的

    0

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