eCAM：中和蛋白质HMGB1防止持久性炎症反应

2012年10月27日费恩斯坦医学研究所研究人员发现，中国菜中常用的一类菜豆能防止危及生命的败血症。这些研究结果发表在最新一期的Evidence-based Complementary and Alternative Medicine杂志上。

研究发现脱氧核糖核酸（DNA）蛋白HMGB1介导炎症。炎症是保持身体健康所必需的，机体丧失炎症反应，伤口将永远无法愈合。然而，持久性和持续性炎症会损伤组织和器官，并导致败血症等疾病。约75万美国人患败血症，每年其中28％到50％的人死亡，而国家医疗保健系统每年花费约达170亿美元。

研究发现中和蛋白质HMGB1可防止持久性和持续性炎症，减轻组织和器官损害。Haichao Wang博士和他的同事们研究发现，在中国常用的提取物食品即原产于印度的绿豆能减少 HMGB1的释放，从而提高小鼠的存活率，从29.4％上升到70％（P <0.05）。

许多传统的药材已被成功开发成为各种炎症性疾病的有效治疗方法，现在该研究已经证实绿豆提取物的治疗潜力。绿豆提取物对脓毒症小鼠具有积极的治疗作用，对人类脓毒症或许也有积极的作用，当然，这需要更多的研究来证明其安全和有效性。

与炎症相关的拓展阅读：

• Nature：炎症性肠道疾病（IBD）的遗传研究
• Blood：抑制血栓及炎症发生的小分子物质多聚磷酸盐被发现
• Curr Biol：应对损伤的炎症反应信号被关闭的确切机制
• Rheumatology：急性痛风发作时SUA水平下降原因与全身炎症反应相关
• ARD：特发性炎症性肌病患者血清维生素D水平低 更多信息请点击：有关炎症更多资讯

It Is Not Just Folklore: The Aqueous Extract of Mung Bean Coat Is Protective against Sepsis

Mung bean (Vigna Radiata) has been traditionally used in China both as nutritional food and herbal medicine against a number of inflammatory conditions since the 1050s. A nucleosomal protein, HMGB1, has recently been established as a late mediator of lethal systemic inflammation with a relatively wider therapeutic window for pharmacological interventions. Here we explored the HMGB1-inhibiting capacity and therapeutic potential of mung bean coat (MBC) extract in vitro and in vivo. We found that MBC extract dose-dependently attenuated LPS-induced release of HMGB1 and several chemokines in macrophage cultures. Oral administration of MBC extract significantly increased animal survival rates from 29.4% (in saline group, mice) to 70% (in experimental MBC extract group, mice, ). In vitro, MBC extract stimulated HMGB1 protein aggregation and facilitated both the formation of microtubule-associatedprotein-1-light-chain-3-(LC3-)containing cytoplasmic vesicles, and the production of LC3-II in macrophage cultures. Consequently, MBC extract treatment led to reduction of cellular HMGB1 levels in macrophage cultures, which was impaired by coaddition of two autophagy inhibitors (bafilomycin A1 and 3-methyladenine). Conclusion. MBC extract is protective against lethal sepsis possibly by stimulating autophagic HMGB1 degradation.