NEJM:大剂量促红细胞生成素不能降低极早产儿2岁时严重神经发育障碍或死亡风险

2020-01-16 MedSci MedSci原创

研究认为,大剂量促红细胞生成素不能降低极早产儿2岁时严重神经发育障碍或死亡风险

大剂量促红细胞生成素在新生儿脑损伤临床前模型中具有神经保护作用,II期临床表明该疗法可能有效,近日研究人员评估了大剂量促红细胞生成素疗法对极度早产儿的益处和安全性。

941名孕24周0天到27周6天的婴儿在出生后24小时内接受促红细胞生成素或安慰剂治疗。每48小时一次,剂量为每公斤体重1000 U,共6剂,然后每周皮下注射3次,维持剂量为每公斤400 U,持续至32周。研究的主要终点为22至26个月龄时死亡或严重的神经发育障碍。

741名早产儿参与研究,其中376名接受促红细胞生成素治疗,365名接受安慰剂治疗。促红细胞生成素组和安慰剂组在2岁时死亡或严重神经发育障碍的发生率上无显著性差异(97名儿童[26%]vs94名儿童[26%];相对风险:1.03)。各组间早产儿视网膜病变率、颅内出血、脓毒病、坏死性小肠结肠炎、支气管肺发育不良、死亡或严重不良事件频率无显著性差异。

研究认为,大剂量促红细胞生成素不能降低极早产儿2岁时严重神经发育障碍或死亡风险。

原始出处:

Sandra E. Juul et al. A Randomized Trial of Erythropoietin for Neuroprotection in Preterm Infants. N Engl J Med, January 16, 2020.

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  5. 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  6. 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    2020-01-18 neurowu
  7. 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