JAHA：BMI对急性心力衰竭患者NT-proBNP与发病率和死亡率之间关系的影响！

2018-02-04 xing.T MedSci原创

由此可见，在急性心衰患者中，BMI无法调节NT-proBNP的预后价值。即使在肥胖患者中，NT-proBNP仍然是急性心力衰竭患者长期死亡率一个有用的预后指标。

较高的体重指数（BMI）与循环中较低的N末端B型利尿钠肽前体（NT-proBNP）水平相关。急性心力衰竭患者BMI与NT-proBNP在临床结局方面的相互作用尚未很好的总结归纳。近日，心血管疾病领域权威杂志JAHA上针对这一问题发表了一篇研究文章。

该研究共纳入了686名来自ASCEND-HF（奈西立肽在失代偿期心衰患者临床有效性的急性研究）临床试验的生物标记亚组研究的参与者，并记录了基线NT-proBNP水平。患者根据世界卫生组织肥胖分类标准（非肥胖：BMI<30kg/m2，I级肥胖：BMI 30-34.9kg/m2，II级肥胖BMI 35-39.9kg/m2，III级肥胖BMI≥40kg/m2）进行分类。研究人员根据BMI分类评估了受试者的基线特征以及30天和180天的结局，并探索了BMI和NT-proBNP之间的相互作用。

参与者的中位年龄为67岁（55-78岁），71％为女性。NT-proBNP水平与BMI呈负相关（P<0.001）。NT-proBNP水平越高，180天死亡率越高（NT-proBNP每增加一倍调整后的风险比为1.40; 95％可信区间为1.16-1.71; P<0.001），但与30天的结局无关。NT-proBNP对180天死亡的影响无法被BMI分类进行改变（相互作用P=0.24）。

由此可见，在急性心衰患者中，BMI无法调节NT-proBNP的预后价值。即使在肥胖患者中，NT-proBNP仍然是急性心力衰竭患者长期死亡率一个有用的预后指标。

原始出处：

Ankeet S. Bhatt,et al. Interaction of Body Mass Index on the Association Between N‐Terminal‐Pro‐b‐Type Natriuretic Peptide and Morbidity and Mortality in Patients With Acute Heart Failure: Findings From ASCEND‐HF (Acute Study of Clinical Effectiveness of Nesiritide in Decompensated Heart Failure).JAHA.2018. https://doi.org/10.1161/JAHA.117.006740

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2018-02-08 lifestar

#发病率#

40 0
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2018-02-13 jyzxjiangqin

BMI对急性心力衰竭的影响.

52 0
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2018-02-06 天涯183

非常好的文章.学习了

62 0
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2018-02-06 zhaohui6731

#AHA#

32 0
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2018-02-06 huiwelcome

#BNP#

42 0
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2018-02-06 mjldent

#NT-proBNP#

42 0
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2018-02-06 许安

#急性心力衰竭#

34 0
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2018-02-06 sunylz

#PRO#

23 0

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JAHA：BMI对急性心力衰竭患者NT-proBNP与发病率和死亡率之间关系的影响！

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