Diabetes Care:1型糖尿病成年人大麻的使用与糖尿病酮症酸中毒风险增加有关

2019-10-19 xing.T MedSci原创

由此可见,1型糖尿病成年人使用大麻与DKA风险增加相关。提供者应告知其患者使用大麻可能引起DKA的潜在风险。

近日,糖尿病领域权威杂志Diabetes Care上发表了一篇研究文章,研究人员旨在评估1型糖尿病患者中大麻使用者与非使用者发生糖尿病性酮症酸中毒(DKA)的频率。

研究人员使用对潜在混杂因素进行校正的Logistic回归模型评估了1型糖尿病成年人通过大麻总物质得分(TSC)衡量的大麻使用量与之后12月期间DKA发生之间的相关性。

在932例1型糖尿病成年人中,61例患者TSC>4,将其归为中度大麻使用者。调整性别、研究访问的年龄和HbA1c后,使用大麻会使1型糖尿病成年人的DKA风险增加两倍(比值比为2.5 [95%CI为1.0-5.9])。

由此可见,1型糖尿病成年人使用大麻与DKA风险增加相关。提供者应告知其患者使用大麻可能引起DKA的潜在风险。 

原始出处:


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  5. 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  6. 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  7. 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createdName=mashirong, createdTime=Mon Oct 21 09:44:00 CST 2019, time=2019-10-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1346126, encodeId=093313461264e, content=<a href='/topic/show?id=ecbb9553661' target=_blank style='color:#2F92EE;'>#酮症酸中毒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95536, encryptionId=ecbb9553661, topicName=酮症酸中毒)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=346311, createdName=wgsun, createdTime=Mon Oct 21 09:44:00 CST 2019, time=2019-10-21, status=1, ipAttribution=)]
    2019-10-21 kcb069
  8. 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  9. 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    2019-10-21 mashirong
  10. 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心血管疾病是导致1型糖尿病(T1DM)患者死亡的主要原因,约35%青少年T1DM进入成年期至少会伴有2个心血管危险因素。因此,非常有必要采取措施预防或逆转T1DM患者的心血管病变。近期科罗拉多大学医学院儿童内分泌科研究人员发表了一项随机对照研究显示,青少年T1DM患者的胰岛素抵抗及心血管健康受损明显,而二甲双胍可有效改善上述异常。

Diabetes Care:1型糖尿病患者严重低血糖和酮症酸中毒发病率和微血管并发症患病率

由此可见,对于1型糖尿病成年人,血糖控制似乎比先前估计的要差。随着HbA1c的增加,所有并发症的发生率均增加。与HbA1c<7%相比,HbA1c≥9%分别与SH和DKA的发病率高出2倍和12倍有关。与较年长的成年人相比,较年轻的成年人血糖控制不佳相关的SH和DKA风险更高。

NEJM:替利珠单抗与1型糖尿病风险

由此可见,替利珠单抗可延迟高风险参与者进展为临床1型糖尿病。