Gastroenterology:幽门螺杆菌感染后胃癌风险因素研究

2019-10-23 MedSci MedSci原创

研究发现,幽门螺杆菌感染后少数民族和烟民的胃癌风险显著升高,治疗幽门螺杆菌感染且仅在根除成功后可降低风险

幽门螺杆菌感染癌最重要的危险因素。近日研究人员考察了H型幽门螺杆菌(Hpylori)检测后非近端腺癌的发生率和危险因素,以确定治疗和根除如何影响癌症风险。

研究人员进行了一项回顾性队列研究,从退伍军人健康管理局收集了371 813名患者(中位年龄,62岁;92.3%男性)的数据,这些患者从1994年1月1日至2018年12月31日期间被诊断为H型幽门螺旋杆菌感染。研究的主要结果是H型幽门螺杆菌感染后30天或更长时间诊断远端胃腺癌。

发现H型幽门螺杆菌感染后5年、10年和20年的累计癌症发生率分别为0.37%、0.5%和0.65%。与癌症有关的因素包括: H型幽门感染时年龄较大 (危险度比1.13)、黑人/非裔美国人(2.00)、亚裔(2.52)、西班牙裔或拉美裔(1.59)、吸烟史(1.38)以及性别(女性患胃腺癌的风险明显低于男性,SHR,0.52),同时根据血清抗体阳性检测H型幽门螺杆菌感染的患者患癌的风险也降低(SHR 0.744)。H型幽门螺杆菌感染而接受治疗后,患者胃癌的风险仍有增加(1.16),但经治疗证实根除H型幽门螺杆菌可降低胃癌的风险(0.24)。

研究发现,幽门螺杆菌感染后少数民族和烟民的胃癌风险显著升高,治疗幽门螺杆菌感染且仅在根除成功后可降低风险。

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    2020-03-25 kcb069
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    2020-09-24 许安
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    2020-09-08 sjq027
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