Ann Rheum Dis:早期弥漫性皮肤SSc的皮肤基因表达分析显示明显的先天和适应性炎症

2019-11-26 xiangting MedSci原创

早期弥漫性SSc患者的皮肤具有明显的先天性和适应性免疫细胞特征。

这项研究旨在确定早期弥漫性系统性硬化症(SSc)的整体皮肤转录组模式,以及它们与晚期疾病的区别。

采用下一代RNA测序技术对来自早期系统性硬化症前瞻性登记队列(PRESS)48例患者(平均病程1.3年)和33例健康对照的皮肤活检RNA进行分析。分析数据的细胞类型特异性特征,并将其与55例来自遗传vs环境硬皮病结局研究队列的既往活检患者及其匹配对照的数据进行比较,这些患者的病程较长(平均7.4年)。还评估了与组织学特征和临床病程的相关性。

PRESS中的SSc患者M296%)和M194%)巨噬细胞以及CD8 T细胞(65%)、CD4 T细胞(60%)和B细胞(69%)很常见。免疫细胞标记物的免疫组化染色与基于基因表达的免疫细胞标记相关。早期弥漫性SSc患者的免疫细胞特征多于病程较长的患者。在多因素模型中,适应性免疫细胞特征与病程较短显著相关,而成纤维细胞和巨噬细胞类型特征与改良的Rodnan皮肤评分(mRSS)相关。免疫细胞特征也与活检前的皮肤厚度进展速度相关,但不能预测随后的mRSS进展。

早期弥漫性SSc患者的皮肤具有明显的先天性和适应性免疫细胞特征。作为主要受累的终末器官,这些特征反映了先前疾病进展的速度。这些发现对理解SSc的发病机理和临床试验设计有影响。

原始出处:

Brian Skaug. Global skin gene expression analysis of early diffuse cutaneous systemic sclerosis shows a prominent innate and adaptive inflammatory profile. Ann Rheum Dis. 25 November 2019.

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    2019-11-28 lujian
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