奥马珠单抗在欧洲获批,成为治疗严重慢性鼻-鼻窦炎的**IgE单抗

2020-08-07 MedSci原创 MedSci原创

Xolair(omalizumab,奥马珠单抗)是唯一获批靶向抗免疫球蛋白E(IgE)单抗。

诺华公司宣布,欧盟委员会(EC)已批准Xolair(omalizumab,奥马珠单抗),用于鼻内注射皮质类固醇激素(INC)不能有效控制、伴有鼻息肉的严重慢性鼻-鼻窦炎(CRSwNP)成人患者,作为INC疗法的附加疗法进行治疗。

III期临床研究表明,Xolair可以减少CRSwNP患者的鼻息肉大小并改善症状和生活质量。Xolair是针对CRSwNP的第一种治疗方法,它专门针对和阻断免疫球蛋白E(IgE),后者是该疾病炎症途径的关键驱动因子。

关于Xolair(omalizumab,奥马珠单抗)

Xolair是唯一获批靶向抗免疫球蛋白E(IgE)单抗,通过降低游离IgE,下调高亲和力IgE受体并限制肥大细胞脱粒,从而降低过敏性炎症级联过程中炎症介质的释放。

See the source image

图片来源:https://www.dovepress.com/omalizumab-for-severe-asthma-toward-personalized-treatment-based-on-bi-peer-reviewed-fulltext-article-JAA

Xolair已在100多个国家,获批用于治疗中度至重度或重度持续性过敏性哮喘。

关于伴有鼻息肉的严重慢性鼻-鼻窦炎(CRSwNP)

伴有鼻息肉的严重慢性鼻-鼻窦炎(CRSwNP)影响全球4%的人,症状表现为鼻塞,鼻涕,面部疼痛/压力以及嗅觉降低或丧失。CRSwNP通过内镜检查进行诊断。该病可能与哮喘,囊性纤维化和阿司匹林过敏有关。

目前,该疾病治疗标准为鼻内注射皮质类固醇激素(INC)。手术和全身性皮质类固醇激素是全世界该病的主要治疗方法。然而,由于鼻息肉的再生,通常不能有效地控制慢性症状。鼻窦手术后,高达80%的人复发,术后3-5年内,大约80%的人仍处于失控状态。

原始出处:

https://www.firstwordpharma.com/node/1746957?tsid=4

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    2021-07-04 xuxuefenfei1002

    学习了

    0

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    2021-03-26 ms3000001349253451

    学习

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    2020-08-09 zhenjiu124
  7. [GetPortalCommentsPageByObjectIdResponse(id=2049562, encodeId=e30f204956263, content=<a href='/topic/show?id=6c3e53e365d' target=_blank style='color:#2F92EE;'>#慢性鼻-鼻窦炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53736, encryptionId=6c3e53e365d, topicName=慢性鼻-鼻窦炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=daa8281, createdName=雕雕, createdTime=Wed Sep 16 12:08:33 CST 2020, time=2020-09-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=995963, encodeId=cbd4995963c3, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210614/424b5ecce9284ae6ac6b017f97345ea0/81d4ed5e06ed4e0b814d9aeefd380006.jpg, createdBy=c3c21361160, createdName=xuxuefenfei1002, createdTime=Sun Jul 04 06:02:55 CST 2021, time=2021-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2069322, encodeId=b2cf206932277, content=<a href='/topic/show?id=4c22949075' target=_blank style='color:#2F92EE;'>#IgE单抗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9490, encryptionId=4c22949075, topicName=IgE单抗)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ad9f79, createdName=般若傻瓜, createdTime=Thu Aug 13 00:08:33 CST 2020, time=2020-08-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=951341, encodeId=55ef95134171, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=343b5451144, createdName=ms3000001349253451, createdTime=Fri Mar 26 09:58:21 CST 2021, time=2021-03-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1339345, encodeId=095113393452a, content=<a href='/topic/show?id=447663054f5' target=_blank style='color:#2F92EE;'>#欧洲#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63054, encryptionId=447663054f5, topicName=欧洲)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/PiajxSqBRaEKxsKDoOOFxGpMibw6lsQFUIicWt7kWGevkdgFhjiban1icD2JdIBmjVo7qX7aSlCSpiaia382nuLKiaI3Cg/132, createdBy=5c442500150, createdName=ms9474365431325850, createdTime=Sun Aug 09 09:08:33 CST 2020, time=2020-08-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1426397, encodeId=6dea142639ef1, content=<a href='/topic/show?id=032b948ec5' target=_blank style='color:#2F92EE;'>#IgE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9487, encryptionId=032b948ec5, topicName=IgE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0cff4064659, createdName=zhenjiu124, createdTime=Sun Aug 09 09:08:33 CST 2020, time=2020-08-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=807027, encodeId=09e980e02739, content=study, beContent=null, objectType=article, channel=null, level=null, likeNumber=106, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210404/a56b065c7a81476d9f645449d1d947bd/5a7f2157b930461ebf3596448f091e39.jpg, createdBy=2df75409411, createdName=ms4000001479344493, createdTime=Sat Aug 08 23:40:50 CST 2020, time=2020-08-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=806833, encodeId=318d8068337a, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3fa35275112, createdName=1482f2f2m05暂无昵称, createdTime=Fri Aug 07 21:02:29 CST 2020, time=2020-08-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=806827, encodeId=593380682e32, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d5c65409489, createdName=ms2000001106348351, createdTime=Fri Aug 07 20:30:33 CST 2020, time=2020-08-07, status=1, ipAttribution=)]
    2020-08-08 ms4000001479344493

    study

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=2049562, encodeId=e30f204956263, content=<a href='/topic/show?id=6c3e53e365d' target=_blank style='color:#2F92EE;'>#慢性鼻-鼻窦炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53736, encryptionId=6c3e53e365d, topicName=慢性鼻-鼻窦炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=daa8281, createdName=雕雕, createdTime=Wed Sep 16 12:08:33 CST 2020, time=2020-09-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=995963, encodeId=cbd4995963c3, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210614/424b5ecce9284ae6ac6b017f97345ea0/81d4ed5e06ed4e0b814d9aeefd380006.jpg, createdBy=c3c21361160, createdName=xuxuefenfei1002, createdTime=Sun Jul 04 06:02:55 CST 2021, time=2021-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2069322, encodeId=b2cf206932277, content=<a href='/topic/show?id=4c22949075' target=_blank style='color:#2F92EE;'>#IgE单抗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9490, encryptionId=4c22949075, topicName=IgE单抗)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ad9f79, createdName=般若傻瓜, createdTime=Thu Aug 13 00:08:33 CST 2020, time=2020-08-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=951341, encodeId=55ef95134171, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=343b5451144, createdName=ms3000001349253451, createdTime=Fri Mar 26 09:58:21 CST 2021, time=2021-03-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1339345, encodeId=095113393452a, content=<a href='/topic/show?id=447663054f5' target=_blank style='color:#2F92EE;'>#欧洲#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63054, encryptionId=447663054f5, topicName=欧洲)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/PiajxSqBRaEKxsKDoOOFxGpMibw6lsQFUIicWt7kWGevkdgFhjiban1icD2JdIBmjVo7qX7aSlCSpiaia382nuLKiaI3Cg/132, createdBy=5c442500150, createdName=ms9474365431325850, createdTime=Sun Aug 09 09:08:33 CST 2020, time=2020-08-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1426397, encodeId=6dea142639ef1, content=<a href='/topic/show?id=032b948ec5' target=_blank style='color:#2F92EE;'>#IgE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9487, encryptionId=032b948ec5, topicName=IgE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0cff4064659, createdName=zhenjiu124, createdTime=Sun Aug 09 09:08:33 CST 2020, time=2020-08-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=807027, encodeId=09e980e02739, content=study, beContent=null, objectType=article, channel=null, level=null, likeNumber=106, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210404/a56b065c7a81476d9f645449d1d947bd/5a7f2157b930461ebf3596448f091e39.jpg, createdBy=2df75409411, createdName=ms4000001479344493, createdTime=Sat Aug 08 23:40:50 CST 2020, time=2020-08-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=806833, encodeId=318d8068337a, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3fa35275112, createdName=1482f2f2m05暂无昵称, createdTime=Fri Aug 07 21:02:29 CST 2020, time=2020-08-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=806827, encodeId=593380682e32, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d5c65409489, createdName=ms2000001106348351, createdTime=Fri Aug 07 20:30:33 CST 2020, time=2020-08-07, status=1, ipAttribution=)]
    2020-08-07 1482f2f2m05暂无昵称

    学习

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=2049562, encodeId=e30f204956263, content=<a href='/topic/show?id=6c3e53e365d' target=_blank style='color:#2F92EE;'>#慢性鼻-鼻窦炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53736, encryptionId=6c3e53e365d, topicName=慢性鼻-鼻窦炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=daa8281, createdName=雕雕, createdTime=Wed Sep 16 12:08:33 CST 2020, time=2020-09-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=995963, encodeId=cbd4995963c3, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210614/424b5ecce9284ae6ac6b017f97345ea0/81d4ed5e06ed4e0b814d9aeefd380006.jpg, createdBy=c3c21361160, createdName=xuxuefenfei1002, createdTime=Sun Jul 04 06:02:55 CST 2021, time=2021-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2069322, encodeId=b2cf206932277, content=<a href='/topic/show?id=4c22949075' target=_blank style='color:#2F92EE;'>#IgE单抗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9490, encryptionId=4c22949075, topicName=IgE单抗)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ad9f79, createdName=般若傻瓜, createdTime=Thu Aug 13 00:08:33 CST 2020, time=2020-08-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=951341, encodeId=55ef95134171, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=343b5451144, createdName=ms3000001349253451, createdTime=Fri Mar 26 09:58:21 CST 2021, time=2021-03-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1339345, encodeId=095113393452a, content=<a href='/topic/show?id=447663054f5' target=_blank style='color:#2F92EE;'>#欧洲#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63054, encryptionId=447663054f5, topicName=欧洲)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/PiajxSqBRaEKxsKDoOOFxGpMibw6lsQFUIicWt7kWGevkdgFhjiban1icD2JdIBmjVo7qX7aSlCSpiaia382nuLKiaI3Cg/132, createdBy=5c442500150, createdName=ms9474365431325850, createdTime=Sun Aug 09 09:08:33 CST 2020, time=2020-08-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1426397, encodeId=6dea142639ef1, content=<a href='/topic/show?id=032b948ec5' target=_blank style='color:#2F92EE;'>#IgE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9487, encryptionId=032b948ec5, topicName=IgE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0cff4064659, createdName=zhenjiu124, createdTime=Sun Aug 09 09:08:33 CST 2020, time=2020-08-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=807027, encodeId=09e980e02739, content=study, beContent=null, objectType=article, channel=null, level=null, likeNumber=106, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210404/a56b065c7a81476d9f645449d1d947bd/5a7f2157b930461ebf3596448f091e39.jpg, createdBy=2df75409411, createdName=ms4000001479344493, createdTime=Sat Aug 08 23:40:50 CST 2020, time=2020-08-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=806833, encodeId=318d8068337a, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3fa35275112, createdName=1482f2f2m05暂无昵称, createdTime=Fri Aug 07 21:02:29 CST 2020, time=2020-08-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=806827, encodeId=593380682e32, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d5c65409489, createdName=ms2000001106348351, createdTime=Fri Aug 07 20:30:33 CST 2020, time=2020-08-07, status=1, ipAttribution=)]
    2020-08-07 ms2000001106348351

    学习

    0