AIM:Harvoni治疗HCV感染的肾移植受者的疗效研究

2016-11-18 MedSci MedSci原创

根据发表在内科医学年鉴的研究显示,基因1型或4型HCV感染的肾移植受者,接受Harvoni治疗24周,是安全有效的。 来自Fondazione IRCCS Ca’ Ganda Ospedale Maggiore Policlinico的Massimo Colombo博士和同事们进行了一项2期研究,评估Harvoni治疗基因1型或4型HCV感染的肾移植受者的有效性和安全性。 该研究包括1

根据发表在内科医学年鉴的研究显示,基因1型或4型HCV感染的肾移植受者,接受Harvoni治疗24周,是安全有效的。

来自Fondazione IRCCS Ca’ Ganda Ospedale Maggiore Policlinico的Massimo Colombo博士和同事们进行了一项2期研究,评估Harvoni治疗基因1型或4型HCV感染的肾移植受者的有效性和安全性。

该研究包括114例患者(平均年龄53岁;男性占53%),其中69%例患者没有接受过治疗,在研究开始前至少6个月接受肾移植术。

大多数患者(91%)为基因1型HCV感染,15%的患者有代偿性肝硬化。所有患者的估计肾小球滤过率(eGFR)≥40 mL/min,中位数eGFR为56 mL/min。

患者被随机分配接受固定剂量的联合雷迪帕韦-索非布韦治疗12周(n =57)或24周(n = 57)。

结果表明,Harvoni治疗12周或24周的患者均达到了主要终点:持续12周的病毒学应答(SVR12)。

13名(11%)患者出现严重不良事件,其中三例是与治疗相关的不良事件(晕厥、肺栓塞、血肌酐增加)。总的来说,头痛(19%)、乏力(14%)和疲劳(10%)是最常见的不良事件。

结果表明,基因1型或4型HCV感染的肾移植受者,接受Harvoni治疗24周,是安全有效的。

原始出处:


Colombo M, et al. Ann Intern Med. 2016;doi:10.7326/M16-1205.

Harvoni well-tolerated in patients with kidney transplant, HCV.
Healio.November 17, 2016

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    2016-11-20 柳叶一刀
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    2016-11-19 老段

    学习一下,赞了!

    0

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    2016-11-18 阿玖

    积分看视频

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