J Rheumatol:腹型肥胖与普通肥胖女性患类风湿性关节炎风险的比较

2020-07-29 xiangting MedSci原创

腹型肥胖与年轻和中年女性的RA风险升高相关,特别是血清学阳性RA。

超重或肥胖会增加女性患类风湿性关节炎(RA)的风险,尤其是年轻女性。腹型肥胖比普通肥胖对全身性炎症的影响更大,因此,这项研究调查了2个前瞻性队列(护士健康研究(NHS)和NHS II)中,与普通肥胖相比,腹型肥胖是否能预测RA风险。

研究随访了NHS的50682名女性(1986-2014年)和NHS II的47597名女性(1993-2015年),这些女性基线时均无RA。通过两年一次的调查问卷收集腰围(WC)、体重指数(BMI)、健康结局和协变量数据。通过病历回顾确定了RA病例和血清学状况。使用时变性Cox比例风险模型分析了WC和BMI与RA风险的关联。对年龄≤55岁的人群进行了重复分析。

在28年的随访中,确定了844例RA患者(NHS 527例, NHS II 317例)。女性腰围>35英寸(88厘米)患RA的风险升高(HR 1.22,95%CI 1.06-1.41)。血清阳性RA也观察到类似关联,在年轻和中年女性中这种关联更强。进一步调整BMI后,关联降为零。相比之下,即使调整了WC后,BMI仍与RA(HR BMI≥30 vs <25 1.33,95%CI 1.05-1.68)和血清阳性RA相关,并且与WC分析一样,这种关联在年轻和中年女性中更强。

腹型肥胖与年轻和中年女性的RA风险升高相关,特别是血清学阳性RA,但是在普通肥胖以外,腹型肥胖并不会单独导致RA风险。

原始出处:

Nathalie E. Marchand. Abdominal Obesity in Comparison with General Obesity and Risk of Developing Rheumatoid Arthritis in Women. J Rheumatol. 15 July 2020.

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    2020-10-21 ms9000000683869843

    类风关

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    2020-07-31 lmm397
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    2020-07-31 nymo

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