Sleep:交感神经调节障碍可能有助于解释慢性失眠症的心血管风险

2018-04-25 国际循环编辑部 国际循环

一项最新的研究报告显示,慢性失眠与交感神经压力反射功能受损和神经对压力的反应增强有关,可增加心血管风险。该项研究结果发表于3月7日的《睡眠》杂志。

一项最新的研究报告显示,慢性失眠与交感神经压力反射功能受损和神经对压力的反应增强有关,可增加心血管风险。该项研究结果发表于3月7日的《睡眠》杂志。

全世界多达15%的成年人患慢性失眠症,这与高血压和心血管风险有关,但这些关联背后的机制仍不清楚。美国芝加哥大学和密西根科技大学的Jason R.Carter博士及其同事的对13例慢性失眠患者和15名健康对照者的交感神经传出(sympathetic neural outflow)、压力反射敏感性以及交感神经和心血管对压力的反应进行了评估。

结果显示,静息血压、心率和肌肉交感神经活动在各组间没有显著差异,但失眠患者的基线交感神经压力反射敏感性明显减弱。与对照组相比,失眠症患者的收缩压对应激反应的反应性提高,肌肉交感神经对应激的反应也提高。

研究者指出,该项研究发现,交感神经过度活动和压力感受器功能障碍是慢性失眠和高血压的潜在机制。结合流行病学证据,这些观察证实了慢性失眠是一种与心血管风险升高相关的心理生理障碍的观点。未来纵向研究可考虑诸如认知行为疗法等治疗失眠和/或药物治疗对慢性失眠患者交感神经和心血管调节的影响。

法国格勒诺布尔大学的Renaud Tamisier博士最近回顾了睡眠障碍患者的血流动力学和自主控制。他指出,毫无疑问,失眠和心血管疾病的密切联系。交感血管张力及其反应性是睡眠障碍的主要因素之一。该项研究作者还发现,失眠症患者的交感神经调节受损,压力反射(baroreflex gain)降低。在失眠症患者中,恢复睡眠质量应是一个目标,以防止交感神经过度活动,从而防止高血压的发生。对于失眠症和高血压患者,专门用于降低血压的药物应该针对交感神经心血管系统。心血管风险的生活方式管理包括饮食(和)锻炼,应包括改善睡眠质量和持续时间的策略。

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    2018-04-27 日月
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    2018-04-26 186****0580(小山羊)

    学习了谢谢了

    0

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    2018-04-26 张新亮1853311252142e2fm

    好文章.学习了

    0

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    2018-04-26 wzb521zf

    一起学习学习

    0

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    2018-04-26 溜溜梅不酸

    学习了.谢谢分享

    0

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    2018-04-25 惠映实验室

    学习了.谢谢分享.

    0

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