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JACC：代谢健康的“胖子”近一半会发展为代谢综合征

2018-04-28 MedSci MedSci原创

心血管代谢综合征肥胖
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目前，关于心血管代谢状态与代谢健康的肥胖（MHO）间的相关性仍未有定论。本研究提出假设，基线状态的MHO是短暂的，并且有可能转变为代谢综合征（MetS），而MetS就可以解释心血管疾病和全因死亡率所表现出的异质性了。本研究纳入了MESA临床研究中的6809名研究对象，经过平均12.2年时间的随访，分析结果发现，与代谢正常且体重正常的对象相比，基线水平的MHO个体与心血管疾病的发生无相关性，但其中有

目前，关于心血管代谢状态与代谢健康的肥胖（MHO）间的相关性仍未有定论。本研究提出假设，基线状态的MHO是短暂的，并且有可能转变为代谢综合征（MetS），而MetS就可以解释心血管疾病和全因死亡率所表现出的异质性了。

本研究纳入了MESA临床研究中的6809名研究对象，经过平均12.2年时间的随访，分析结果发现，与代谢正常且体重正常的对象相比，基线水平的MHO个体与心血管疾病的发生无相关性，但其中有近一半个体在随访期间发展为了代谢综合征，这些个体称之为不稳定MHO。与稳定MHO或体重正常的个体相比，不稳定MHO个体发生心血管疾病的风险明显增高（[OR]： 1.60； 95% [CI]： 1.14 - 2.25）。此外，代谢综合征占肥胖与心血管疾病发生关系的62%（44% to 100%）。

研究结果显示，代谢健康的肥胖个体并不是稳定的，有一定概率会发展为代谢综合征，而这就与其心血管疾病发生和全因死亡率呈明显相关性。

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    2018-11-21 hbwxf

    #JACC#

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    2018-05-02 墨子卿

    学习

    0

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    2018-05-01 墨子卿

    学习

    0

  4. 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    2018-04-30 12498568m50暂无昵称

    #ACC#

    0

  5. 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    2018-04-30 zhouqu_8

    #综合征#

    0

  6. 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    2018-04-30 宋威

    #代谢健康#

    0

  7. 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authenticateStatus=null, createdAvatar=, createdBy=1e452500029, createdName=12498568m50暂无昵称, createdTime=Mon Apr 30 02:04:00 CST 2018, time=2018-04-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1431201, encodeId=3361143120125, content=<a href='/topic/show?id=f9b9e9124a8' target=_blank style='color:#2F92EE;'>#综合征#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79124, encryptionId=f9b9e9124a8, topicName=综合征)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Mon Apr 30 02:04:00 CST 2018, time=2018-04-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1571388, encodeId=c63d15e1388ee, content=<a href='/topic/show?id=fcf425411da' target=_blank style='color:#2F92EE;'>#代谢健康#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=25411, encryptionId=fcf425411da, topicName=代谢健康)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e7a515732936, createdName=宋威, createdTime=Mon Apr 30 02:04:00 CST 2018, time=2018-04-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=310527, encodeId=647231052e6f, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKN5reeHfufkHMZbvsPGqziahTGYm5I2mFZd5Tn0z1WmN9vOh6H4PEU2UOhXaHTicce198icJ3Kdtp7A/132, createdBy=c77b2198018, createdName=墨子卿, createdTime=Mon Apr 30 00:21:36 CST 2018, time=2018-04-30, status=1, ipAttribution=), 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GetPortalCommentsPageByObjectIdResponse(id=310096, encodeId=461331009656, content=学习了.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Sat Apr 28 12:34:45 CST 2018, time=2018-04-28, status=1, ipAttribution=)]
    2018-04-30 墨子卿

    好

    0

  8. 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    2018-04-29 墨子卿

    胖子的忧桑

    0

  9. 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    2018-04-28 医者仁心5538

    应该控制体重

    0

  10. 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GetPortalCommentsPageByObjectIdResponse(id=310096, encodeId=461331009656, content=学习了.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Sat Apr 28 12:34:45 CST 2018, time=2018-04-28, status=1, ipAttribution=)]
    2018-04-28 1ddf0692m34(暂无匿称)

    学习了.谢谢分享

    0

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