Am J Gastroenterol:结肠镜监测在控制溃疡性结肠炎进展中的作用

2019-04-15 MedSci MedSci原创

研究认为,接受结肠镜监测检查是有效的控制溃疡性结肠炎进展的方法,特别是直肠和乙状结肠应该进行更彻底的检查

近日研究人员考察了实际手术中溃疡性结肠炎(UC)切除组织中相关的直肠癌(CRC)和异型增生病例,以确定结肠镜在UC管理中的有效性并优化其应用。

本次研究为回顾性分析,对406例(238例CRC和168例异型增生)UC患者的临床病理资料进行分析,确定早发性CRC(UC发病后<8年)的发生率及危险因素,并对CRC病变的分布进行了评估。

研究发现,未接受结肠镜跟踪监测组的肿瘤分期明显高于监测组(p<0.001)。监测组的OS明显优于非监测组(5年OS:89%vs70%)。17%的患者在UC发病后8年内发生CRC。UC发病年龄是早发性CRC(<8年)的一个危险因素和较好的预测因素(p<0.01,AUC:0.85)。CRC最常见的患病部位为直肠(51%)和乙状结肠(20%)。16%的患者存在多个CRC。

研究认为,接受结肠镜监测检查是有效的控制溃疡性结肠炎进展的方法,特别是直肠和乙状结肠应该进行更彻底的检查。

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    2019-07-21 nymo
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    2019-11-06 许安
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    2019-04-17 zhouqu_8

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