Mol Med Rep:树突细胞中CD86的沉默能够调控过敏性鼻炎患者T细胞中细胞因子的产生

2019-09-24 AlexYang MedSci原创

最近,有研究人员在来源于过敏性鼻炎(AR)患者的外周血样中调查了共刺激分子T淋巴细胞活化抗原CD86在树突细胞(DCs)中的表达和作用,并与那些来源于健康个体的样本进行了比较。研究发现,与对照组相比,来源于AR患者外周血样本的成熟DCs细胞表达更高水平的共刺激分子CD86,而不是CD80。CD86在DCs中的表达水平在转染了慢病毒载体siRNA后显著减少。更多的是,与DCs细胞共培养的T细胞产生的

最近,有研究人员在来源于过敏性鼻炎(AR)患者的外周血样中调查了共刺激分子T淋巴细胞活化抗原CD86在树突细胞(DCs)中的表达和作用,并与那些来源于健康个体的样本进行了比较。

研究发现,与对照组相比,来源于AR患者外周血样本的成熟DCs细胞表达更高水平的共刺激分子CD86,而不是CD80。CD86在DCs中的表达水平在转染了慢病毒载体siRNA后显著减少。更多的是,与DCs细胞共培养的T细胞产生的转化生长因子-β1水平在siRNA组中显著增加,而白介素(IL)-4和IL-5的产生则显著减少。

最后,研究人员发现,他们目前的发现表明了在过敏性炎症中,CD86可能在T细胞/2型辅助T细胞不平衡中具有关键作用。

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过敏原免疫疗法(AIT)是目前过敏性鼻炎(AR)唯一的病因学和可能的治愈疗法。最近,有研究人员探索调查了AIT中,表观调节因子zeste同源体2增强子(EZH2)在树突细胞(DCs)激活中的作用。研究包括了56名AR患者的临床信息,他们均接受了AIT治疗。其中,30名受试者进行的是皮下免疫治疗(SCTI),26名受试者进行的是舌下免疫治疗(SLIT)。研究发现,EZH2的表达在循环mDCs和pDC

Blood:体外激活和依鲁替尼治疗可恢复CLL Vγ9Vδ2-T细胞的抗CLL细胞的细胞毒性作用

中心点:健康的Vγ9Vδ2-T细胞可识别裂解CLL细胞,但CLL患者来源的Vγ9Vδ2-T细胞的细胞毒性和细胞因子合成受损。用自体moDCs在体外激活Vγ9Vδ2-T细胞可逆转其功能障碍,依鲁替尼可促进产生抗肿瘤的TH1表型。摘要:自体(αβ)T细胞为基础的治疗策略用于慢性淋巴细胞白血病(CLL)的疗效一直较为温和。具有强力的抗淋巴瘤活性的细胞毒性T淋巴细胞通过主要组织相容性复合物(MHC)非依赖

Immunity:树突细胞指导T细胞发挥作用的新型分子机制

图片摘自:imgarcade.com日前,刊登在国际杂志Immunity上的一项研究报告中,来自圣路易斯大学(Saint Louis University)的研究人员通过研究揭示了机体免疫系统中的树突细胞如何指挥T淋巴细胞学习对机体自身细胞的耐受性。机体免疫系统往往会通过避免过度反应或反应不足所带来的危险来维持机体健康,而机体免疫功能不全的个体往往非常容易患病,从另一方面来讲,机体免疫系统如果过于

Blood:肿瘤抑制因子调节了树突细胞的分化与成熟

近日,来自美国乔治城大学医学中心的研究人员发现,肿瘤抑制因子p15Ink4b调节了传统树突细胞的分化与成熟。相关研究成果于5月24日发表在Blood上。 p15INK4B基因是近年来发现的细胞周期蛋白依赖性激酶抑制因子(CKI)家族中的一个新成员,能抑制多种肿瘤细胞的增殖。研究发现,在急性髓细胞性白血病及其它的髓系疾病,肿瘤抑制因子p15Ink4b频繁的被甲基化而失活。 树突细胞(DCs)作为

PNAS:树突细胞参与调节过敏反应

深入认识感染可能有助于科学家们理解过敏症和开发新的治疗方法。在一项新研究中,英国爱丁堡大学研究人员对免疫系统的研究揭示出一种参与身体对诸如花粉或宠物毛发之类的过敏原产生的免疫反应的细胞所发挥的作用。这种细胞被称作树突细胞,已知它起着协调身体对感染产生免疫反应的作用。它是通过让免疫系统激活抵抗感染的白细胞来发挥功能的。 研究人员证实当身体免疫反应过于活跃且可能造成伤害时,树突细胞也能够在抑制这种免