Allergy Asthma Clin Immunol:儿童哮喘、过敏性鼻炎和过敏性皮肤炎共有的产前影响研究

2019-10-04 AlexYang MedSci原创

儿童过敏性疾病的增加是一个全球健康问题。最近,有研究人员调查了儿童哮喘的产前风险因素,并且强调了儿童哮喘、过敏性鼻炎(AR)和过敏性皮肤炎(AD)可能的产前共有影响。研究总共包括了628878对母亲和孩子,其中43915(6.98%)名儿童在6岁之前发展为哮喘。研究发现男性性别(aOR 1.50, 95%CI 1.47-1.53)、母亲哮喘(aOR 1.80, 95%CI 1.71-1.89)、母

儿童过敏性疾病的增加是一个全球健康问题。最近,有研究人员调查了儿童哮喘的产前风险因素,并且强调了儿童哮喘、过敏性鼻炎(AR)和过敏性皮肤炎(AD)可能的产前共有影响。

研究总共包括了628878对母亲和孩子,其中43915(6.98%)名儿童在6岁之前发展为哮喘。研究发现男性性别(aOR 1.50, 95%CI 1.47-1.53)、母亲哮喘(aOR 1.80, 95%CI 1.71-1.89)、母亲过敏性鼻炎(aOR 1.33, 95%CI 1.30-1.37)、早产(aOR 1.32, 95%CI 1.27-1.37)、低出生体重(aOR 1.14, 95%CI 1.10-1.19)和剖宫产(aOR 1.10, 95%CI 1.08-1.13)是儿童哮喘的独立预测因子。较高的城市化水平和较少的哥哥姐姐数量与哮喘呈现剂量依赖的模式。明显的是,研究人员鉴定了母亲哮喘与儿童哮喘的相关性(aOR 1.80, 95%CI 1.71-1.89)比母亲消化和儿童AR之间的相关性(aOR 1.67, 95%CI 1.50-1.87)和儿童AD的相关性(aOR 1.31, 95%CI 1.22-1.40)更强。相似的,母亲AR与儿童AR(aOR 1.62, 95%CI 1.53-1.72)相关性要比母亲AR和儿童哮喘(aOR 1.33, 95%CI 1.30-1.37)和儿童AD (aOR 1.35, 95%CI 1.31-1.40)相关性更高。更多的是,母亲过敏性疾病的数量与儿童3种过敏性呈现剂量依赖的模式。

最后,研究人员指出,他们的研究提供了母亲对儿童哮喘的影响,并阐释了儿童哮喘、AR和AD共有的母亲方面的影响。

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    2020-01-05 skhzy
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    2019-10-06 膀胱癌
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    2019-10-06 qilu_qi

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