medRxiv: 新冠病毒还损伤肾脏和睾丸!苏州学者研究,应加强睾丸病变随访

2020-02-21 xujing 中国循环杂志

近日,南京医科大学附属苏州医院学者在预印本平台medRxiv上发表研究称,肾脏和睾丸组织中血管紧张素转换酶2(ACE2)呈高表达,为新型冠状病毒的靶器官。

近日,南京医科大学附属苏州医院学者在预印本平台medRxiv上发表研究称,肾脏和睾丸组织中血管紧张素转换酶2(ACE2)呈高表达,为新型冠状病毒的靶器官。

已有研究表明,部分患者除呼吸系统损伤外,还存在肾功能异常甚至肾损害,其相关机制尚不清楚。 
 
该研究分析了三份新型冠状病毒感染患者临床资料(分别包含6例、41例和99例患者),同样发现,除了呼吸系统受到损伤之外,10%的患者发生肾功能异常,此外,7%的患者发生急性肾损伤。
 
血管紧张素转换酶2(ACE2)是介导2019-nCoV进入人细胞的主要受体之一,与SARS一致。
 
研究者通过在线数据库分析了ACE2在不同人体器官中的表达水平。
 
研究结果表明,ACE2在肾小管细胞、间质细胞和睾丸输精管细胞中均有高表达。病毒可能直接与ACE2阳性细胞结合,损伤患者的肾脏和睾丸组织。
 
研究者提醒,临床治疗过程中应当进行肾功能评估和干预。
 
此外,研究者指出,病毒引起的睾丸损伤可能是一种晚期并发症,以往的研究结果表明,睾丸炎是SARS的一种并发症,除了睾丸炎,病毒性睾丸组织损伤还可能导致不育、睾丸肿瘤。
 
鉴于大部分新冠病毒患者是青壮年男性,研究者建议要加强后期睾丸病变的随访。

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    2020-02-23 zhangph
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    2020-02-21 公卫新人

    新冠肺炎,疫情何时才能消失

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