Nutr Metab Cardiovasc Dis:摄入富含大豆的饮食或能通过调节肠道微生物组来影响机体血压

2020-08-09 佚名 细胞

富含大豆的饮食往往与降血压及预防动脉粥样硬化之间存在一定关联,但目前研究人员并不完全清楚大豆改善机体心脏健康背后的分子机制。研究发现,摄入大豆或会通过调节机体肠道微生物组来影响机体的血压。

富含大豆的饮食往往与降血压及预防动脉粥样硬化之间存在一定关联,但目前研究人员并不完全清楚大豆改善机体心脏健康背后的分子机制。

近日,一项刊登在国际杂志Nutrition, Metabolism and Cardiovascular Diseases上题为“Soy food intake associates with changes in the metabolome and reduced blood pressure in a gut microbiota dependent manner”的研究报告中,来自范德堡大学等机构的科学家们就通过研究发现,摄入大豆或会通过调节机体肠道微生物组来影响机体的血压,肠道微生物组是生活在人类机体胃肠道系统中多样化的细菌菌群。

研究者表示,大豆摄入量较高的健康人群机体中两种特殊细菌的水平较低,即普氏菌属(Prevotella)和小杆菌属(Dialister);普氏菌属细菌与机体血压上升直接相关,拥有这种类型细菌的个体往往有着更高的BMI值以及更多的炎症循环标志物,但这种情况只会发生在小杆菌属细菌不存在的情况下。

有意思的是,研究者发现,拥有上述两种菌群(普氏菌属和小杆菌属)的个体中并不存在多种心脏疾病风险因素,这或许就表明,肠道微生物组或许能成为机体饮食大豆摄入与系统性代谢之间相互作用的重要中间介导因素,后期研究人员还将继续深入研究大豆类食物摄入、机体代谢和肠道微生物组之间的精细化关系,从而为开发治疗诸如高血压等血管疾病的新型疗法提供新的思路和希望。

原始出处:

Rachana D Shah, Zheng-Zheng Tang, Guanhua Chen,et al.Soy food intake associates with changes in the metabolome and reduced blood pressure in a gut microbiota dependent manner.Nutr Metab Cardiovasc Dis. 2020;S0939-4753(20)30155-1. doi: 10.1016/j.numecd.2020.05.001.

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    2020-12-20 一闲
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    2020-08-17 quxin068
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    2020-09-09 guojianrong
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