Heart:中国复发性急性心肌梗死发病率、预测因素和预后影响

2020-09-18 MedSci原创 MedSci原创

三分之一的AMI复发事件发生较早。复发性AMI与1年死亡率密切相关,尤其是发生于早期的患者。在此早期加强监护并改善推荐的出院药物处方可能会减少复发性AMI。

急性心肌梗死(AMI)后复发性AMI的发生率、预测因素和预后影响尚未明确,中国复发性AMI的数据也尚未明确。

近日,心脏病领域权威杂志Heart上发表了一篇研究文章,研究人员分析了3387例入住53所医院的并活着出院的AMI患者,研究人员使用时间依赖性Cox回归评估复发性AMI与1年死亡率之间的关系。AMI复发事件分为早期(1-30天)、晚期(31-180天)和极晚期(181-365天)。研究人员通过Kaplan-Meier方法对受试者1年死亡率的影响进行了评估,并通过对数秩检验进行了比较。研究人员使用多变量建模来确定与复发性AMI相关的因素。

受试者平均(SD)年龄为60.7(11.9)岁,女性为783人(23.1%)。受试者中观察到的1年复发性AMI发生率为2.5%(95%CI为2.00至3.07),前30天内发生了35.7%的事件。

复发性AMI与1年死亡率相关,校正后的HR为25.42(95%CI为15.27至42.34)。早期复发性AMI与1年最高死亡率53.3%相关(对数秩检验p<0.001)。AMI复发的预测因素包括75-84岁、院内经皮冠状动脉介入治疗、初次入院时心率>90分钟/次、肾功能不全以及出院时未服用任何基于指南的药物。

由此可见,三分之一的AMI复发事件发生较早。复发性AMI与1年死亡率密切相关,尤其是发生于早期的患者。在此早期加强监护并改善推荐的出院药物处方可能会减少复发性AMI。

原始出处:

Jiali Song.et al.Incidence, predictors, and prognostic impact of recurrent acute myocardial infarction in China.heart.2020.https://heart.bmj.com/content/early/2020/09/16/heartjnl-2020-317165

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    2020-09-25 咻凡

    三分之一的AMI复发事件发生较早。复发性AMI与1年死亡率密切相关,尤其是发生于早期的患者。在此早期加强监护并改善推荐的出院药物处方可能会减少复发性AMI。该如何避免?

    0

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  5. [GetPortalCommentsPageByObjectIdResponse(id=1823668, encodeId=7f031823668b3, content=<a href='/topic/show?id=b2873e9220e' target=_blank style='color:#2F92EE;'>#发病率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37922, encryptionId=b2873e9220e, topicName=发病率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aa0e14, createdName=lifestar, createdTime=Fri Aug 06 10:20:51 CST 2021, time=2021-08-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1909841, encodeId=b2b41909841d8, content=<a href='/topic/show?id=8f1f42518d8' target=_blank style='color:#2F92EE;'>#复发性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42518, encryptionId=8f1f42518d8, topicName=复发性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=hb2008ye, createdTime=Sun Mar 07 09:20:51 CST 2021, time=2021-03-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=888236, encodeId=69a9888236b4, content=三分之一的AMI复发事件发生较早。复发性AMI与1年死亡率密切相关,尤其是发生于早期的患者。在此早期加强监护并改善推荐的出院药物处方可能会减少复发性AMI。该如何避免?, beContent=null, objectType=article, channel=null, level=null, likeNumber=108, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b58d5402080, createdName=咻凡, createdTime=Fri Sep 25 11:39:27 CST 2020, time=2020-09-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1264337, encodeId=e528126433eea, content=<a href='/topic/show?id=daf1100226fb' target=_blank style='color:#2F92EE;'>#预测因素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100226, encryptionId=daf1100226fb, topicName=预测因素)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a57b78, createdName=朱睿睿, createdTime=Sun Sep 20 03:20:51 CST 2020, time=2020-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1357601, encodeId=abcc135e6018c, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Sun Sep 20 03:20:51 CST 2020, time=2020-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1563369, encodeId=eb461563369df, content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Sun Sep 20 03:20:51 CST 2020, time=2020-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=886364, encodeId=d8b88863649a, content=好!, beContent=null, objectType=article, channel=null, level=null, likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200918/bb1148c0125a47c29e0bd6478be9a7aa/bd4f0a61ab644b8885ec49a5df4e54a2.jpg, createdBy=b2125419342, createdName=ms3000001370148967, createdTime=Fri Sep 18 12:24:39 CST 2020, time=2020-09-18, status=1, ipAttribution=)]
    2020-09-20 zhaojie88
  6. [GetPortalCommentsPageByObjectIdResponse(id=1823668, encodeId=7f031823668b3, content=<a href='/topic/show?id=b2873e9220e' target=_blank style='color:#2F92EE;'>#发病率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37922, encryptionId=b2873e9220e, topicName=发病率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aa0e14, createdName=lifestar, createdTime=Fri Aug 06 10:20:51 CST 2021, time=2021-08-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1909841, encodeId=b2b41909841d8, content=<a href='/topic/show?id=8f1f42518d8' target=_blank style='color:#2F92EE;'>#复发性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42518, encryptionId=8f1f42518d8, topicName=复发性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=hb2008ye, createdTime=Sun Mar 07 09:20:51 CST 2021, time=2021-03-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=888236, encodeId=69a9888236b4, content=三分之一的AMI复发事件发生较早。复发性AMI与1年死亡率密切相关,尤其是发生于早期的患者。在此早期加强监护并改善推荐的出院药物处方可能会减少复发性AMI。该如何避免?, beContent=null, objectType=article, channel=null, level=null, likeNumber=108, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b58d5402080, createdName=咻凡, createdTime=Fri Sep 25 11:39:27 CST 2020, time=2020-09-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1264337, encodeId=e528126433eea, content=<a href='/topic/show?id=daf1100226fb' target=_blank style='color:#2F92EE;'>#预测因素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100226, encryptionId=daf1100226fb, topicName=预测因素)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a57b78, createdName=朱睿睿, createdTime=Sun Sep 20 03:20:51 CST 2020, time=2020-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1357601, encodeId=abcc135e6018c, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Sun Sep 20 03:20:51 CST 2020, time=2020-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1563369, encodeId=eb461563369df, content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Sun Sep 20 03:20:51 CST 2020, time=2020-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=886364, encodeId=d8b88863649a, content=好!, beContent=null, objectType=article, channel=null, level=null, likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200918/bb1148c0125a47c29e0bd6478be9a7aa/bd4f0a61ab644b8885ec49a5df4e54a2.jpg, createdBy=b2125419342, createdName=ms3000001370148967, createdTime=Fri Sep 18 12:24:39 CST 2020, time=2020-09-18, status=1, ipAttribution=)]
    2020-09-20 slcumt
  7. [GetPortalCommentsPageByObjectIdResponse(id=1823668, encodeId=7f031823668b3, content=<a href='/topic/show?id=b2873e9220e' target=_blank style='color:#2F92EE;'>#发病率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37922, encryptionId=b2873e9220e, topicName=发病率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aa0e14, createdName=lifestar, createdTime=Fri Aug 06 10:20:51 CST 2021, time=2021-08-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1909841, encodeId=b2b41909841d8, content=<a href='/topic/show?id=8f1f42518d8' target=_blank style='color:#2F92EE;'>#复发性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42518, encryptionId=8f1f42518d8, topicName=复发性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=hb2008ye, createdTime=Sun Mar 07 09:20:51 CST 2021, time=2021-03-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=888236, encodeId=69a9888236b4, content=三分之一的AMI复发事件发生较早。复发性AMI与1年死亡率密切相关,尤其是发生于早期的患者。在此早期加强监护并改善推荐的出院药物处方可能会减少复发性AMI。该如何避免?, beContent=null, objectType=article, channel=null, level=null, likeNumber=108, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b58d5402080, createdName=咻凡, createdTime=Fri Sep 25 11:39:27 CST 2020, time=2020-09-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1264337, encodeId=e528126433eea, content=<a href='/topic/show?id=daf1100226fb' target=_blank style='color:#2F92EE;'>#预测因素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100226, encryptionId=daf1100226fb, topicName=预测因素)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a57b78, createdName=朱睿睿, createdTime=Sun Sep 20 03:20:51 CST 2020, time=2020-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1357601, encodeId=abcc135e6018c, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Sun Sep 20 03:20:51 CST 2020, time=2020-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1563369, encodeId=eb461563369df, content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Sun Sep 20 03:20:51 CST 2020, time=2020-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=886364, encodeId=d8b88863649a, content=好!, beContent=null, objectType=article, channel=null, level=null, likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200918/bb1148c0125a47c29e0bd6478be9a7aa/bd4f0a61ab644b8885ec49a5df4e54a2.jpg, createdBy=b2125419342, createdName=ms3000001370148967, createdTime=Fri Sep 18 12:24:39 CST 2020, time=2020-09-18, status=1, ipAttribution=)]
    2020-09-18 ms3000001370148967

    好!

    0

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