J Endod:含咖啡酸纳米涂层的MTA促进宿主的免疫反应、血管生成和牙本质发生

2020-08-04 lishiting MedSci原创

这篇研究的目的是为了评估MTA是否可以被咖啡酸(CA)改变而形成咖啡酸/MTA (CAMTA)水门汀,并评估其物理化学和生物学特质以及它对免疫抑制和血管发生的能力。

这篇研究的目的是为了评估MTA是否可以被咖啡酸(CA)改变而形成咖啡酸/MTA (CAMTA)水门汀,并评估其物理化学和生物学特质以及它对免疫抑制和血管发生的能力。

研究将MTA浸入含CA的tris缓冲液中以使MTA粉末形成CA涂层。通过XRD和拉伸应力-应变试验评估CAMTA的物理特征并评估MTA的修饰效果。随后,将CAMTA水门汀浸入SBF以评估其羟基磷灰石形成能力和Si的释放模式。此外,分别采用RAW 264.7细胞和人牙髓干细胞(hDPSCs)评估其免疫抑制能力和细胞应答。采用hDPSCs评估CAMTA的血管生成能力。

XRD结果显示,CA能够成功的涂布于MTA表面,同时并不损伤或丢失MTA原有的结构特征,因此MTA可保持其原有的功效。与MTA相比,CAMTA具有更高的机械特质,并且具有更粗糙的瘢痕表面,推测其可以增加表面黏附、增殖和成血管以及成牙本质相关蛋白的分泌。此外,与MTA相比,CAMTA能够增加羟基磷灰石的形成和免疫抑制能力。

结论:与MTA相比,CAMTA水门汀能够改善其物理化学和生物学特性。此外,CAMTA水门汀能够增强成牙本质、成血管以及免疫抑制能力。研究所有结果表明,CAMTA水门汀将是未来临床和组织工程应用的一种生物材料。

原始出处:

Ming-Gene Tu, Alvin Kai-Xing Lee, et al. Caffeic Acid-coated Nanolayer on Mineral Trioxide Aggregate Potentiate the Host Immune Responses, Angiogenesis, and Odontogenesis. J Endod., 2020 Jul 12;S0099-2399(20)30490-8. doi: 10.1016/j.joen.2020.07.003.

 

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    2020-08-06 liuxiaona
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    2020-08-06 wincls
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