Sci Rep:TGIF1和FBXO11位点与慢性中耳炎相关

2017-10-14 AlexYang MedSci原创

慢性中耳炎积液(COME)是儿童中引起听力损失最为常见的原因,并且具有高度的可遗传性。之前,研究人员利用小鼠模型鉴定了 Fbxo11、 Evi1、 Tgif1和Nisch为潜在的风险位点。最近,有研究人员从UK 的35家医院招募了10岁及以下且因COME经历外科手术治疗的儿童和他们的核心家庭作为研究群体。研究人员检测了 Fbxo11、 Evi1、 Tgif1和Nisch中耳炎之间的关系,并且探索了

慢性中耳炎积液(COME)是儿童中引起听力损失最为常见的原因,并且具有高度的可遗传性。之前,研究人员利用小鼠模型鉴定了 Fbxo11、 Evi1、 Tgif1和Nisch为潜在的风险位点。最近,有研究人员从UK 的35家医院招募了10岁及以下且因COME经历外科手术治疗的儿童和他们的核心家庭作为研究群体。研究人员检测了 Fbxo11、 Evi1、 Tgif1和Nisch中耳炎之间的关系,并且探索了芬兰国家的一个案例-对照群体研究显著结果的重复性。

研究人员检测了1296个家庭(3282名个体),发现了中耳炎与 TGIF1位点且在rs88183 的T等位基因(p=0.006, OR 1.39)、在rs1962914 的G等位基因(p=0.006, OR 1.39),以及FBXO11位点的在 rs10490302的A等位基因(p=0.016, OR 1.17)和rs2537742的G等位基因(p=0.038, OR 1.16)均具有强烈的相关性。结果并不具有重复性。最后,研究人员指出,该研究支持了中耳炎与FBXO11位点多态性具有联系,但是该研究是首次报道中耳炎与TGIF1具有相关性。另外,FBXO11和TGIF1参与了TGF-β信号通路,表明了该信号通路也许在从急性中耳炎到慢性中耳炎转化中是重要的,并且是潜在分子靶标。

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  2. [GetPortalCommentsPageByObjectIdResponse(id=1344497, encodeId=b888134449ebf, content=<a href='/topic/show?id=a01b2239e0b' target=_blank style='color:#2F92EE;'>#中耳炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=22397, encryptionId=a01b2239e0b, topicName=中耳炎)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/vLodSSFTQLpHtfwJicWJibSWH7pbiauxvpCMvQIv0N9Oes8vHkDkCIW2HNDkt7icUq3RCZiaDcHR9Rap17fFySRbiaFg/132, createdBy=9f202500205, createdName=ms3297076796458174, createdTime=Mon Oct 16 08:56:00 CST 2017, time=2017-10-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=253237, encodeId=e25d25323ee4, content=不错的文章值得推荐, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=04f22055142, createdName=131****2916, createdTime=Sun Oct 15 23:16:55 CST 2017, time=2017-10-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=252909, encodeId=8524252909c5, content=慢性中耳炎积液(COME)是儿童中引起听力损失最为常见的原因.并且具有高度的可遗传性, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7cJ6ejWUr2nIia8qOvAKNdLHr32Df6G8iaoaOx6pHaoiacwp26DaslxZHCGbibZhhCGven4rvmWP60GahtzgFjgCjR/0, createdBy=6b111703011, createdName=有备才能无患, createdTime=Sat Oct 14 21:24:25 CST 2017, time=2017-10-14, status=1, ipAttribution=)]
    2017-10-15 131****2916

    不错的文章值得推荐

    0

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    2017-10-14 有备才能无患

    慢性中耳炎积液(COME)是儿童中引起听力损失最为常见的原因.并且具有高度的可遗传性

    0