Sci Rep:来氟米特单药治疗类风湿性关节炎与联合疗法的比较

2020-07-29 xiangting MedSci原创

这些结果表明低剂量LEF单药治疗并不劣于联合治疗。

来氟米特(LEF)是治疗类风湿性关节炎的常规合成疾病改善抗类风湿药物(csDMARDs)。但是,比较LEF单药治疗与联合其他csDMARDs治疗疗效的研究很少。这项研究评估了LEF单药治疗(88例)和联合治疗(361例)的疗效和安全性。

3个月后,单药治疗组和联合治疗组的28关节疾病活动性评分(DAS28)、健康评估问卷(HAQ)、血沉(ESR)和C反应蛋白(CRP)无显著差异(P均>0.05)。根据欧洲抗风湿联盟(EULAR)应答标准,发现两组的DAS28应答率相似(P>0.05)。此外,两组的安全性相似。亚组分析发现,三种联合疗法(LEF +甲氨蝶呤(MTX)、LEF +羟氯喹(HCQ)和LEF + MTX + HCQ)与LEF单药治疗的疗效无差异。此外,当LEF剂量小于40 mg/天时,低剂量与高剂量的疗效没有显著差异。

总体而言,这些结果表明低剂量LE​​F单药治疗并不劣于联合治疗。

原始出处:

Daihua Deng. Leflunomide monotherapy versus combination therapy with conventional synthetic disease-modifying antirheumatic drugs for rheumatoid arthritis: a retrospective study. Sci Rep. 23 July 2020.

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    2020-07-31 lmm397
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