Prostate Cance P D:诊断时前列腺癌风险情况趋势分析

2019-07-13 AlexYang MedSci原创

在过去的几十年中,前列腺癌(PCa)诊断方法逐渐从侵入性前列腺特异性抗原(PSA)筛选中演化而来。虽然这些演化的目的是减少过度诊断和治疗,然而关于诊断时对PCa风险分布的下游影响所知很少。最近,有研究人员为了更好的理解这些影响,利用国家男性群体调查了当代诊断时PCa风险的趋势。研究人员利用国家癌症数据库鉴定了2004年到2014年的那些活检确定为局部前列腺恶性肿瘤的男性(T1-4N0M0),且总共

在过去的几十年中,前列腺癌(PCa)诊断方法逐渐从侵入性前列腺特异性抗原(PSA)筛选中演化而来。虽然这些演化的目的是减少过度诊断和治疗,然而关于诊断时对PCa风险分布的下游影响所知很少。最近,有研究人员为了更好的理解这些影响,利用国家男性群体调查了当代诊断时PCa风险的趋势。

研究人员利用国家癌症数据库鉴定了2004年到2014年的那些活检确定为局部前列腺恶性肿瘤的男性(T1-4N0M0),且总共鉴定了755567名男性。研究发现,低风险PCa的男性比例在2004年和2014年之间减少(8.32到27.23%, p<0.001),局部中度风险(40.49到46.72%, p<0.001)和高风险诊断(21.19到26.05%, p<0.001)的比例均具有显著的增加。这些增加分别主要是由格林森等级7和格林森等级8-10癌症比例的增加导致的。那些具有转移性疾病的男性从2004年的3251(2.88%)名增加到了2014年的6886(7.19%)名(p<0.001)。

最后,研究人员指出,局部中等/高风险转移性PCa比例在过去的几十年中是增加的,而低风险疾病的比例减少。该转变主要是由于高等级疾病比例的增加引起。

原始出处:

Sean A. Fletcher, Nicolas von Landenberg, Alexander P. Cole et al. Contemporary national trends in prostate cancer risk profile at diagnosis. Prostate Cance P D. 24 Jun 2019

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    2019-09-23 sjq027
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  5. [GetPortalCommentsPageByObjectIdResponse(id=1791579, encodeId=348b1e91579ed, content=<a href='/topic/show?id=b77f14e4541' target=_blank style='color:#2F92EE;'>#Prostate Ca#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14745, encryptionId=b77f14e4541, topicName=Prostate Ca)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a691420, createdName=30397604, createdTime=Sat Apr 18 06:26:00 CST 2020, time=2020-04-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2061861, encodeId=7c9d20618613c, content=<a href='/topic/show?id=e6e1e15509f' target=_blank style='color:#2F92EE;'>#癌风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71550, encryptionId=e6e1e15509f, topicName=癌风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d58a435, createdName=sjq027, createdTime=Mon Sep 23 20:26:00 CST 2019, time=2019-09-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1667568, encodeId=6ddc166e5687b, content=<a href='/topic/show?id=b9559296103' target=_blank style='color:#2F92EE;'>#趋势分析#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=92961, encryptionId=b9559296103, topicName=趋势分析)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=20bf26147921, createdName=bugit, createdTime=Tue Feb 18 04:26:00 CST 2020, time=2020-02-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2022581, encodeId=2ba42022581a0, content=<a href='/topic/show?id=42b532553af' target=_blank style='color:#2F92EE;'>#前列腺癌风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32553, encryptionId=42b532553af, topicName=前列腺癌风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d2f42500210, createdName=12498ef1m31(暂无昵称), createdTime=Mon Aug 12 21:26:00 CST 2019, time=2019-08-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1364505, encodeId=dd2c1364505e2, content=<a href='/topic/show?id=7c5615628ad' target=_blank style='color:#2F92EE;'>#ROS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15628, encryptionId=7c5615628ad, topicName=ROS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=acc3210, createdName=lsndxfj, createdTime=Mon Jul 15 04:26:00 CST 2019, time=2019-07-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1602179, encodeId=a7e716021e9a4, content=<a href='/topic/show?id=2f801469e57' target=_blank style='color:#2F92EE;'>#PRO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14697, encryptionId=2f801469e57, topicName=PRO)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a60b18898917, createdName=sunylz, createdTime=Mon Jul 15 04:26:00 CST 2019, time=2019-07-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=369663, encodeId=3bc036966337, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160304/IMG56D94856B1B5D6405.jpg, createdBy=27931687771, createdName=一个字-牛, createdTime=Sun Jul 14 17:57:16 CST 2019, time=2019-07-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1040497, encodeId=3054104049e95, content=前列腺癌相关研究,学习了,谢谢梅斯, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Sat Jul 13 16:26:00 CST 2019, time=2019-07-13, status=1, ipAttribution=)]
    2019-07-15 lsndxfj
  6. [GetPortalCommentsPageByObjectIdResponse(id=1791579, encodeId=348b1e91579ed, content=<a href='/topic/show?id=b77f14e4541' target=_blank style='color:#2F92EE;'>#Prostate Ca#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14745, encryptionId=b77f14e4541, topicName=Prostate Ca)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a691420, createdName=30397604, createdTime=Sat Apr 18 06:26:00 CST 2020, time=2020-04-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2061861, encodeId=7c9d20618613c, content=<a href='/topic/show?id=e6e1e15509f' target=_blank style='color:#2F92EE;'>#癌风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71550, encryptionId=e6e1e15509f, topicName=癌风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d58a435, createdName=sjq027, createdTime=Mon Sep 23 20:26:00 CST 2019, time=2019-09-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1667568, encodeId=6ddc166e5687b, content=<a href='/topic/show?id=b9559296103' target=_blank style='color:#2F92EE;'>#趋势分析#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=92961, encryptionId=b9559296103, topicName=趋势分析)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=20bf26147921, createdName=bugit, createdTime=Tue Feb 18 04:26:00 CST 2020, time=2020-02-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2022581, encodeId=2ba42022581a0, content=<a href='/topic/show?id=42b532553af' target=_blank style='color:#2F92EE;'>#前列腺癌风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32553, encryptionId=42b532553af, topicName=前列腺癌风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d2f42500210, createdName=12498ef1m31(暂无昵称), createdTime=Mon Aug 12 21:26:00 CST 2019, time=2019-08-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1364505, encodeId=dd2c1364505e2, content=<a href='/topic/show?id=7c5615628ad' target=_blank style='color:#2F92EE;'>#ROS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15628, encryptionId=7c5615628ad, topicName=ROS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=acc3210, createdName=lsndxfj, createdTime=Mon Jul 15 04:26:00 CST 2019, time=2019-07-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1602179, encodeId=a7e716021e9a4, content=<a href='/topic/show?id=2f801469e57' target=_blank style='color:#2F92EE;'>#PRO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14697, encryptionId=2f801469e57, topicName=PRO)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a60b18898917, createdName=sunylz, createdTime=Mon Jul 15 04:26:00 CST 2019, time=2019-07-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=369663, encodeId=3bc036966337, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160304/IMG56D94856B1B5D6405.jpg, createdBy=27931687771, createdName=一个字-牛, createdTime=Sun Jul 14 17:57:16 CST 2019, time=2019-07-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1040497, encodeId=3054104049e95, content=前列腺癌相关研究,学习了,谢谢梅斯, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Sat Jul 13 16:26:00 CST 2019, time=2019-07-13, status=1, ipAttribution=)]
    2019-07-15 sunylz
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    2019-07-14 一个字-牛

    学习了谢谢分享

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    2019-07-13 misszhang

    前列腺癌相关研究,学习了,谢谢梅斯

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