Eur Heart J-Card Img:PM2.5是高风险冠状动脉斑块发展的危险因素

2019-08-17 xing.T MedSci原创

由此可见,在环境空气中暴露于更高浓度的PM2.5与高风险冠状动脉斑块的发展显著相关。

近日,心血管领域权威杂志Eur Heart J-Card Img上发表了一篇研究文章,研究人员的目的是探究长期接触空气动力学直径<2.5μm的颗粒物(PM2.5)是否与冠状动脉斑块的发生发展有关。

该研究纳入了364名韩国首尔居民,他们以≥2年的间隔时间接受了冠状动脉断层血管造影(CCTA)。研究人员计算了每名参与者在两次CCTA之间的住宅PM2.5平均浓度。该研究的主要终点是高风险斑块(HRP)的发展情况,其定义为具有低衰减、斑点钙化和重塑的斑块,次要终点是总斑块及其组分体积的增加。

在基线时没有HRP的患者中(n=341),20例患者在随访CCTA时检测到HRP,其居住地PM2.5浓度显著高于无HRP的参与者(25.8±2.0 vs. 25.0±1.7μg/m3; P=0.047)。PM2.5浓度的增加与随访时HRP发生率的增加有关[校正风险比(aHR)为1.62,95%置信区间(CI)为1.22-2.15,P<0.001]。在次要分析中,PM2.5浓度与新发展斑块中纤维脂肪或坏死核心成分形成的风险增加相关(aHR为1.41,95%CI为1.23-1.61,P<0.001),并且预先存在的斑块中总斑块体积进展的风险增加(aHR为1.14,95%CI为1.05-1.23,P=0.002)。

由此可见,在环境空气中暴露于更高浓度的PM2.5与高风险冠状动脉斑块的发展显著相关。

原始出处:

Seokhun Yang,et al. PM2.5 concentration in the ambient air is a risk factor for the development of high-risk coronary plaques.Eur Heart J-Card Img. 2019. https://doi.org/10.1093/ehjci/jez209

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    2019-08-19 zhaojie88
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    2019-08-19 slcumt

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