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Stem Cells：缺氧诱导因子-1α增强干细胞外泌体中Jagged 1介导的血管生成能力

2017-04-06 MedSci MedSci原创

缺氧诱导因子－1a干细胞
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与缺血相关的血管生长不足仍然是血管医学中尚未解决的问题。已经有研究显示间充质干细胞（MSC）可以通过缺氧的机制促进血管生成。缺氧诱导因子（HIF）-1α在MSC中的过表达通过在移植组织中诱导血管生成来增强其治疗潜力。近期，一项发表在杂志Stem Cells上的研究评估了HIF-1α过表达的供体MSC（HIF-MSC）释放的外泌体对内皮细胞血管生成的作用。 此项研究显示：HIF-MSC中的

与缺血相关的血管生长不足仍然是血管医学中尚未解决的问题。已经有研究显示间充质干细胞（MSC）可以通过缺氧的机制促进血管生成。

缺氧诱导因子（HIF）-1α在MSC中的过表达通过在移植组织中诱导血管生成来增强其治疗潜力。

近期，一项发表在杂志Stem Cells上的研究评估了HIF-1α过表达的供体MSC（HIF-MSC）释放的外泌体对内皮细胞血管生成的作用。 

此项研究显示：HIF-MSC中的外泌体分泌增强。外泌体中miRNA和蛋白质的Omics分析显示Notch途径是外泌体信号的候选介体。有趣的是，此项研究还发现Jagged1是包裹在MSC外泌体中的唯一Notch配体，其在HIF-MSC中比在MSC对照组中更丰富。

将MSC和HIF-MSC外泌体中含有的Jagged1加入到内皮细胞中可以引起Notch靶基因的转录变化，并在毛细管样管形成的体外模型中诱导血管的生成，并且这两种过程均可以被HIF-1α激发。

最后，此项研究还发现，在Matrigel塞试验中，将MSC和HIF-MSC外泌体中含有的Jagged1皮下注射可以诱导体内血管的生成，当它们衍生自HIF-MSC的外泌体时更加明显。

上述所有Jagged1介导的作用均可以通过预先使用Jagged1抗体孵育阻断。

此项研究结果表明，源自稳定过表达HIF-1α－MSC的外泌体可以部分通过Jagged1的增加其血管生成能力。

原始出处：
Gonzalez-King H, García NA, et al. Hypoxia inducible factor-1 alpha potentiates Jagged 1-mediated angiogenesis by mesenchymal stem cell-derived exosomes. Stem Cells. 2017 Apr 4. doi: 10.1002/stem.2618.

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objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16778, encryptionId=8cc416e78f3, topicName=STEM)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d1067833268, createdName=12498bb3m92(暂无昵称), createdTime=Sat Apr 08 05:53:00 CST 2017, time=2017-04-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1614940, encodeId=797c1614940db, content=<a href='/topic/show?id=d74a44e2e7' target=_blank style='color:#2F92EE;'>#cells#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=17, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4472, encryptionId=d74a44e2e7, topicName=cells)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=659819575782, createdName=124988c7m101暂无昵称, createdTime=Sat Apr 08 05:53:00 CST 2017, time=2017-04-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=185686, 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time=2017-04-06, status=1, ipAttribution=)]
    2017-12-20 维他命

    #CEL#

    0

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time=2017-04-06, status=1, ipAttribution=)]
    2017-07-09 yykkxiaodou

    #stem cells#

    0

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time=2017-04-06, status=1, ipAttribution=)]
    2018-02-28 zhaozhouchifen

    #Cell#

    0

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time=2017-04-06, status=1, ipAttribution=)]
    2017-06-05 hb2008ye

    #stem cell#

    0

  5. 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time=2017-04-06, status=1, ipAttribution=)]
    2017-04-28 1696533704_45270454

    #缺氧诱导因子#

    0

  6. 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time=2017-04-06, status=1, ipAttribution=)]
    2017-04-08 12498bb3m92(暂无昵称)

    #STEM#

    0

  7. 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time=2017-04-06, status=1, ipAttribution=)]
    2017-04-08 124988c7m101暂无昵称

    #cells#

    0

  8. 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encodeId=def318568676, content=卒中与缺氧有很大关系。, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzcjoLTEEgkSSQ8pVIiaf4a4INaoMLBV16QEk3dvvBRpicwIwmDGv0jePErJ4aE9ibVBDPtkialQLT9Bs/0, createdBy=04811949400, createdName=邓启付, createdTime=Fri Apr 07 07:18:13 CST 2017, time=2017-04-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=185570, encodeId=86981855e063, content=非常好的文章，学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7LIiaRZTzJ3SEfiauCzTMPW7YvPPYLNJBXG9oh6Al1icq2VQQkIHWxqXehcicTS62YKJVBhxeth3wggw/0, createdBy=7ce01621306, createdName=天涯183, createdTime=Thu Apr 06 15:33:49 CST 2017, time=2017-04-06, status=1, ipAttribution=)]
    2017-04-07 邓启付

    卒中与缺氧有很大关系。

    0

  9. 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encodeId=def318568676, content=卒中与缺氧有很大关系。, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzcjoLTEEgkSSQ8pVIiaf4a4INaoMLBV16QEk3dvvBRpicwIwmDGv0jePErJ4aE9ibVBDPtkialQLT9Bs/0, createdBy=04811949400, createdName=邓启付, createdTime=Fri Apr 07 07:18:13 CST 2017, time=2017-04-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=185570, encodeId=86981855e063, content=非常好的文章，学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7LIiaRZTzJ3SEfiauCzTMPW7YvPPYLNJBXG9oh6Al1icq2VQQkIHWxqXehcicTS62YKJVBhxeth3wggw/0, createdBy=7ce01621306, createdName=天涯183, createdTime=Thu Apr 06 15:33:49 CST 2017, time=2017-04-06, status=1, ipAttribution=)]
    2017-04-06 天涯183

    非常好的文章，学习了

    0