Blood:糖皮质激素诱导性嗜酸性粒细胞减少!

2020-07-26 QQY MedSci原创

中心点:

中心点:

活细胞追踪显示糖皮质激素诱导嗜酸性粒细胞骨髓迁移。

该效应依赖于糖皮质激素反应趋化因子受体CXCR4。

摘要:

糖皮质激素被认为是治疗各种嗜酸性粒细胞疾病的一线药物。在服用后的数小时内,即可使血液中嗜酸性粒细胞发生短暂而明显的降低。糖皮质激素诱导嗜酸性粒细胞减少的这种现象是使用糖皮质激素治疗嗜酸性粒细胞疾病的基础,它引起了临床医生长达70年的兴趣,但迄今为止其潜在机制仍尚未完全明确。

为了解决这个问题,Hong等首次在三种动物中研究了循环嗜酸性粒细胞对体内糖皮质激素的反应,发现在恒河猴中的反应与人类很相似,而非在小鼠中。随后,研究人员开发了一种分离技术,从恒河猴外周血中纯化嗜酸性粒细胞,并通过一系列PET/CT成像对予以糖皮质激素前后锆-89-喹啉标记的嗜酸性粒细胞进行实时追踪。

结果显示,糖皮质激素能快速诱导嗜酸性粒细胞的骨髓归巢。糖皮质激素诱导的嗜酸性粒细胞减少和骨髓迁移的动力学与糖皮质激素反应趋化因子受体CXCR4的诱导动力学一致,选择性阻断CXCR4可减少或消除糖皮质激素诱导的早期血嗜酸性粒细胞减少。

综上所述,本研究结果表明糖皮质激素诱导的嗜酸性粒细胞减少是由CXCR4依赖性的嗜酸性粒细胞骨髓迁移所导致的。这些发现为糖皮质激素在嗜酸性粒细胞性疾病中的作用机制提供了基础原理,对糖皮质激素耐药性的研究和更有针对性的治疗方法的发展具有促进意义。

原始出处:

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (7)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1813281, encodeId=398318132810c, content=<a href='/topic/show?id=92b5918e845' target=_blank style='color:#2F92EE;'>#诱导性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=91878, encryptionId=92b5918e845, topicName=诱导性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4193478, createdName=wgx306, createdTime=Mon Mar 29 10:09:04 CST 2021, time=2021-03-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2003880, encodeId=bcb3200388017, content=<a href='/topic/show?id=3f43e621302' target=_blank style='color:#2F92EE;'>#粒细胞减少#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76213, encryptionId=3f43e621302, topicName=粒细胞减少)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7f52347, createdName=soongzhihua, createdTime=Tue Jun 08 11:09:04 CST 2021, time=2021-06-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1701288, encodeId=3dbf1e01288c0, content=<a href='/topic/show?id=b5f6e6827fb' target=_blank style='color:#2F92EE;'>#糖皮质#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76827, encryptionId=b5f6e6827fb, topicName=糖皮质)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0f4230340116, createdName=Tommy1959, createdTime=Fri Jul 09 19:09:04 CST 2021, time=2021-07-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=814722, encodeId=19e6814e2287, content=有用, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7a5b1318764, createdName=wangshentang007, createdTime=Fri Aug 28 13:05:50 CST 2020, time=2020-08-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1324655, encodeId=c83b1324655f2, content=<a href='/topic/show?id=dad84023404' target=_blank style='color:#2F92EE;'>#嗜酸性粒细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=40234, encryptionId=dad84023404, topicName=嗜酸性粒细胞)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTK17mLkWpia3T92NlEWTkEhrhZa7XPNic2JqQumEicZXGYFG6Ww5SCIl0Uq62bhhPnibAqIZDHtRva92A/132, createdBy=e0752500025, createdName=江川靖瑶, createdTime=Tue Jul 28 04:09:04 CST 2020, time=2020-07-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1600413, encodeId=3c691600413bf, content=<a href='/topic/show?id=3565e21649e' target=_blank style='color:#2F92EE;'>#皮质激素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72164, encryptionId=3565e21649e, topicName=皮质激素)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=21015, createdName=heli0118, createdTime=Tue Jul 28 04:09:04 CST 2020, time=2020-07-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=804596, encodeId=3ca580459647, content=很好, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=641b1790770, createdName=ms7005894153384393, createdTime=Sun Jul 26 13:32:02 CST 2020, time=2020-07-26, status=1, ipAttribution=)]
    2021-03-29 wgx306
  2. [GetPortalCommentsPageByObjectIdResponse(id=1813281, encodeId=398318132810c, content=<a href='/topic/show?id=92b5918e845' target=_blank style='color:#2F92EE;'>#诱导性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=91878, encryptionId=92b5918e845, topicName=诱导性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4193478, createdName=wgx306, createdTime=Mon Mar 29 10:09:04 CST 2021, time=2021-03-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2003880, encodeId=bcb3200388017, content=<a href='/topic/show?id=3f43e621302' target=_blank style='color:#2F92EE;'>#粒细胞减少#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76213, encryptionId=3f43e621302, topicName=粒细胞减少)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7f52347, createdName=soongzhihua, createdTime=Tue Jun 08 11:09:04 CST 2021, time=2021-06-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1701288, encodeId=3dbf1e01288c0, content=<a href='/topic/show?id=b5f6e6827fb' target=_blank style='color:#2F92EE;'>#糖皮质#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76827, encryptionId=b5f6e6827fb, topicName=糖皮质)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0f4230340116, createdName=Tommy1959, createdTime=Fri Jul 09 19:09:04 CST 2021, time=2021-07-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=814722, encodeId=19e6814e2287, content=有用, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7a5b1318764, createdName=wangshentang007, createdTime=Fri Aug 28 13:05:50 CST 2020, time=2020-08-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1324655, encodeId=c83b1324655f2, content=<a href='/topic/show?id=dad84023404' target=_blank style='color:#2F92EE;'>#嗜酸性粒细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=40234, encryptionId=dad84023404, topicName=嗜酸性粒细胞)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTK17mLkWpia3T92NlEWTkEhrhZa7XPNic2JqQumEicZXGYFG6Ww5SCIl0Uq62bhhPnibAqIZDHtRva92A/132, createdBy=e0752500025, createdName=江川靖瑶, createdTime=Tue Jul 28 04:09:04 CST 2020, time=2020-07-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1600413, encodeId=3c691600413bf, content=<a href='/topic/show?id=3565e21649e' target=_blank style='color:#2F92EE;'>#皮质激素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72164, encryptionId=3565e21649e, topicName=皮质激素)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=21015, createdName=heli0118, createdTime=Tue Jul 28 04:09:04 CST 2020, time=2020-07-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=804596, encodeId=3ca580459647, content=很好, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=641b1790770, createdName=ms7005894153384393, createdTime=Sun Jul 26 13:32:02 CST 2020, time=2020-07-26, status=1, ipAttribution=)]
  3. [GetPortalCommentsPageByObjectIdResponse(id=1813281, encodeId=398318132810c, content=<a href='/topic/show?id=92b5918e845' target=_blank style='color:#2F92EE;'>#诱导性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=91878, encryptionId=92b5918e845, topicName=诱导性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4193478, createdName=wgx306, createdTime=Mon Mar 29 10:09:04 CST 2021, time=2021-03-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2003880, encodeId=bcb3200388017, content=<a href='/topic/show?id=3f43e621302' target=_blank style='color:#2F92EE;'>#粒细胞减少#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76213, encryptionId=3f43e621302, topicName=粒细胞减少)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7f52347, createdName=soongzhihua, createdTime=Tue Jun 08 11:09:04 CST 2021, time=2021-06-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1701288, encodeId=3dbf1e01288c0, content=<a href='/topic/show?id=b5f6e6827fb' target=_blank style='color:#2F92EE;'>#糖皮质#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76827, encryptionId=b5f6e6827fb, topicName=糖皮质)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0f4230340116, createdName=Tommy1959, createdTime=Fri Jul 09 19:09:04 CST 2021, time=2021-07-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=814722, encodeId=19e6814e2287, content=有用, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7a5b1318764, createdName=wangshentang007, createdTime=Fri Aug 28 13:05:50 CST 2020, time=2020-08-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1324655, encodeId=c83b1324655f2, content=<a href='/topic/show?id=dad84023404' target=_blank style='color:#2F92EE;'>#嗜酸性粒细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=40234, encryptionId=dad84023404, topicName=嗜酸性粒细胞)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTK17mLkWpia3T92NlEWTkEhrhZa7XPNic2JqQumEicZXGYFG6Ww5SCIl0Uq62bhhPnibAqIZDHtRva92A/132, createdBy=e0752500025, createdName=江川靖瑶, createdTime=Tue Jul 28 04:09:04 CST 2020, time=2020-07-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1600413, encodeId=3c691600413bf, content=<a href='/topic/show?id=3565e21649e' target=_blank style='color:#2F92EE;'>#皮质激素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72164, encryptionId=3565e21649e, topicName=皮质激素)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=21015, createdName=heli0118, createdTime=Tue Jul 28 04:09:04 CST 2020, time=2020-07-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=804596, encodeId=3ca580459647, content=很好, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=641b1790770, createdName=ms7005894153384393, createdTime=Sun Jul 26 13:32:02 CST 2020, time=2020-07-26, status=1, ipAttribution=)]
  4. [GetPortalCommentsPageByObjectIdResponse(id=1813281, encodeId=398318132810c, content=<a href='/topic/show?id=92b5918e845' target=_blank style='color:#2F92EE;'>#诱导性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=91878, encryptionId=92b5918e845, topicName=诱导性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4193478, createdName=wgx306, createdTime=Mon Mar 29 10:09:04 CST 2021, time=2021-03-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2003880, encodeId=bcb3200388017, content=<a href='/topic/show?id=3f43e621302' target=_blank style='color:#2F92EE;'>#粒细胞减少#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76213, encryptionId=3f43e621302, topicName=粒细胞减少)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7f52347, createdName=soongzhihua, createdTime=Tue Jun 08 11:09:04 CST 2021, time=2021-06-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1701288, encodeId=3dbf1e01288c0, content=<a href='/topic/show?id=b5f6e6827fb' target=_blank style='color:#2F92EE;'>#糖皮质#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76827, encryptionId=b5f6e6827fb, topicName=糖皮质)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0f4230340116, createdName=Tommy1959, createdTime=Fri Jul 09 19:09:04 CST 2021, time=2021-07-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=814722, encodeId=19e6814e2287, content=有用, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7a5b1318764, createdName=wangshentang007, createdTime=Fri Aug 28 13:05:50 CST 2020, time=2020-08-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1324655, encodeId=c83b1324655f2, content=<a href='/topic/show?id=dad84023404' target=_blank style='color:#2F92EE;'>#嗜酸性粒细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=40234, encryptionId=dad84023404, topicName=嗜酸性粒细胞)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTK17mLkWpia3T92NlEWTkEhrhZa7XPNic2JqQumEicZXGYFG6Ww5SCIl0Uq62bhhPnibAqIZDHtRva92A/132, createdBy=e0752500025, createdName=江川靖瑶, createdTime=Tue Jul 28 04:09:04 CST 2020, time=2020-07-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1600413, encodeId=3c691600413bf, content=<a href='/topic/show?id=3565e21649e' target=_blank style='color:#2F92EE;'>#皮质激素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72164, encryptionId=3565e21649e, topicName=皮质激素)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=21015, createdName=heli0118, createdTime=Tue Jul 28 04:09:04 CST 2020, time=2020-07-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=804596, encodeId=3ca580459647, content=很好, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=641b1790770, createdName=ms7005894153384393, createdTime=Sun Jul 26 13:32:02 CST 2020, time=2020-07-26, status=1, ipAttribution=)]
    2020-08-28 wangshentang007

    有用

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1813281, encodeId=398318132810c, content=<a href='/topic/show?id=92b5918e845' target=_blank style='color:#2F92EE;'>#诱导性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=91878, encryptionId=92b5918e845, topicName=诱导性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4193478, createdName=wgx306, createdTime=Mon Mar 29 10:09:04 CST 2021, time=2021-03-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2003880, encodeId=bcb3200388017, content=<a href='/topic/show?id=3f43e621302' target=_blank style='color:#2F92EE;'>#粒细胞减少#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76213, encryptionId=3f43e621302, topicName=粒细胞减少)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7f52347, createdName=soongzhihua, createdTime=Tue Jun 08 11:09:04 CST 2021, time=2021-06-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1701288, encodeId=3dbf1e01288c0, content=<a href='/topic/show?id=b5f6e6827fb' target=_blank style='color:#2F92EE;'>#糖皮质#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76827, encryptionId=b5f6e6827fb, topicName=糖皮质)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0f4230340116, createdName=Tommy1959, createdTime=Fri Jul 09 19:09:04 CST 2021, time=2021-07-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=814722, encodeId=19e6814e2287, content=有用, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7a5b1318764, createdName=wangshentang007, createdTime=Fri Aug 28 13:05:50 CST 2020, time=2020-08-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1324655, encodeId=c83b1324655f2, content=<a href='/topic/show?id=dad84023404' target=_blank style='color:#2F92EE;'>#嗜酸性粒细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=40234, encryptionId=dad84023404, topicName=嗜酸性粒细胞)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTK17mLkWpia3T92NlEWTkEhrhZa7XPNic2JqQumEicZXGYFG6Ww5SCIl0Uq62bhhPnibAqIZDHtRva92A/132, createdBy=e0752500025, createdName=江川靖瑶, createdTime=Tue Jul 28 04:09:04 CST 2020, time=2020-07-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1600413, encodeId=3c691600413bf, content=<a href='/topic/show?id=3565e21649e' target=_blank style='color:#2F92EE;'>#皮质激素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72164, encryptionId=3565e21649e, topicName=皮质激素)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=21015, createdName=heli0118, createdTime=Tue Jul 28 04:09:04 CST 2020, time=2020-07-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=804596, encodeId=3ca580459647, content=很好, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=641b1790770, createdName=ms7005894153384393, createdTime=Sun Jul 26 13:32:02 CST 2020, time=2020-07-26, status=1, ipAttribution=)]
  6. [GetPortalCommentsPageByObjectIdResponse(id=1813281, encodeId=398318132810c, content=<a href='/topic/show?id=92b5918e845' target=_blank style='color:#2F92EE;'>#诱导性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=91878, encryptionId=92b5918e845, topicName=诱导性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4193478, createdName=wgx306, createdTime=Mon Mar 29 10:09:04 CST 2021, time=2021-03-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2003880, encodeId=bcb3200388017, content=<a href='/topic/show?id=3f43e621302' target=_blank style='color:#2F92EE;'>#粒细胞减少#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76213, encryptionId=3f43e621302, topicName=粒细胞减少)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7f52347, createdName=soongzhihua, createdTime=Tue Jun 08 11:09:04 CST 2021, time=2021-06-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1701288, encodeId=3dbf1e01288c0, content=<a href='/topic/show?id=b5f6e6827fb' target=_blank style='color:#2F92EE;'>#糖皮质#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76827, encryptionId=b5f6e6827fb, topicName=糖皮质)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0f4230340116, createdName=Tommy1959, createdTime=Fri Jul 09 19:09:04 CST 2021, time=2021-07-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=814722, encodeId=19e6814e2287, content=有用, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7a5b1318764, createdName=wangshentang007, createdTime=Fri Aug 28 13:05:50 CST 2020, time=2020-08-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1324655, encodeId=c83b1324655f2, content=<a href='/topic/show?id=dad84023404' target=_blank style='color:#2F92EE;'>#嗜酸性粒细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=40234, encryptionId=dad84023404, topicName=嗜酸性粒细胞)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTK17mLkWpia3T92NlEWTkEhrhZa7XPNic2JqQumEicZXGYFG6Ww5SCIl0Uq62bhhPnibAqIZDHtRva92A/132, createdBy=e0752500025, createdName=江川靖瑶, createdTime=Tue Jul 28 04:09:04 CST 2020, time=2020-07-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1600413, encodeId=3c691600413bf, content=<a href='/topic/show?id=3565e21649e' target=_blank style='color:#2F92EE;'>#皮质激素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72164, encryptionId=3565e21649e, topicName=皮质激素)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=21015, createdName=heli0118, createdTime=Tue Jul 28 04:09:04 CST 2020, time=2020-07-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=804596, encodeId=3ca580459647, content=很好, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=641b1790770, createdName=ms7005894153384393, createdTime=Sun Jul 26 13:32:02 CST 2020, time=2020-07-26, status=1, ipAttribution=)]
  7. [GetPortalCommentsPageByObjectIdResponse(id=1813281, encodeId=398318132810c, content=<a href='/topic/show?id=92b5918e845' target=_blank style='color:#2F92EE;'>#诱导性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=91878, encryptionId=92b5918e845, topicName=诱导性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4193478, createdName=wgx306, createdTime=Mon Mar 29 10:09:04 CST 2021, time=2021-03-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2003880, encodeId=bcb3200388017, content=<a href='/topic/show?id=3f43e621302' target=_blank style='color:#2F92EE;'>#粒细胞减少#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76213, encryptionId=3f43e621302, topicName=粒细胞减少)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7f52347, createdName=soongzhihua, createdTime=Tue Jun 08 11:09:04 CST 2021, time=2021-06-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1701288, encodeId=3dbf1e01288c0, content=<a href='/topic/show?id=b5f6e6827fb' target=_blank style='color:#2F92EE;'>#糖皮质#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76827, encryptionId=b5f6e6827fb, topicName=糖皮质)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0f4230340116, createdName=Tommy1959, createdTime=Fri Jul 09 19:09:04 CST 2021, time=2021-07-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=814722, encodeId=19e6814e2287, content=有用, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7a5b1318764, createdName=wangshentang007, createdTime=Fri Aug 28 13:05:50 CST 2020, time=2020-08-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1324655, encodeId=c83b1324655f2, content=<a href='/topic/show?id=dad84023404' target=_blank style='color:#2F92EE;'>#嗜酸性粒细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=40234, encryptionId=dad84023404, topicName=嗜酸性粒细胞)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTK17mLkWpia3T92NlEWTkEhrhZa7XPNic2JqQumEicZXGYFG6Ww5SCIl0Uq62bhhPnibAqIZDHtRva92A/132, createdBy=e0752500025, createdName=江川靖瑶, createdTime=Tue Jul 28 04:09:04 CST 2020, time=2020-07-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1600413, encodeId=3c691600413bf, content=<a href='/topic/show?id=3565e21649e' target=_blank style='color:#2F92EE;'>#皮质激素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72164, encryptionId=3565e21649e, topicName=皮质激素)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=21015, createdName=heli0118, createdTime=Tue Jul 28 04:09:04 CST 2020, time=2020-07-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=804596, encodeId=3ca580459647, content=很好, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=641b1790770, createdName=ms7005894153384393, createdTime=Sun Jul 26 13:32:02 CST 2020, time=2020-07-26, status=1, ipAttribution=)]
    2020-07-26 ms7005894153384393

    很好

    0

相关资讯

二甲双胍可减轻激素副作用!Lancet子刊研究

近期发表在Lancet子刊的一项2期临床研究表明,二甲双胍会让糖皮质激素“更完美”,可保留其抗炎作用,而消除其代谢方面的副作用。

Semin Arthritis Rheu:风湿性多肌痛的合并症

在诊断前后,PMR患者的合并症负担都很高。

糖皮质激素在感染相关急症,如何使用?

糖皮质激素是一类基本结构为类固醇(甾体),有抗过敏、抗炎、抗毒、抗休克、抑制免疫应答、抑制气道高反应性等作用的药物,临床可用于感染相关疾病等的治疗。

Lancet:维持低剂量糖皮质激素治疗对低疾病活动度的类风湿关节炎患者症状控制更为有效

研究认为,对于使用托珠单抗和至少24周的糖皮质激素治疗达到低疾病活动度的类风湿关节炎患者,继续维持每天5mg的糖皮质激素治疗对疾病的控制效果优于逐渐减少糖皮质激素治疗方案

Lancet Diabetes Endo:二甲双胍可改善长期糖皮质激素治疗导致的不良事件

研究认为,二甲双胍可改善需采用糖皮质激素治疗的炎症性疾病部分代谢和临床结果,值得进一步研究

Semin Arthritis Rheu:类风湿性关节炎中与羟氯喹、甲氨蝶呤、生物制剂和糖皮质激素相关的糖尿病

在RA患者中,羟氯喹、甲氨蝶呤和TNFi与患糖尿病的风险降低相关,而糖皮质激素与糖尿病的风险升高相关。