JCEM:青春期甲状腺功能的变化情况

2020-01-12 xing.T MedSci原创

由此可见,青少年甲状腺功能检查结果呈现出复杂的性别差异。实施青春期特定参考范围可能是合适的。

目前,尚无关于青春期甲状腺功能的大型纵向研究。近日,内分泌和代谢性疾病领域权威杂志Journal of Clinical Endocrinology & Metabolism上发表了一篇研究文章,这项研究旨在评估TSH、fT3和fT4的纵向变化趋势,并确定特定年龄的参考范围。

研究人员使用Abbott ARCHITECT免疫分析法测量了Brisbane纵向双胞胎研究中3415名参与者在12、14和16岁时的甲状腺功能。纵向分析调整了体重指数和青春期。

在女孩中,平均fT4(±SE)在12至14岁之间增加(增加至0.30±0.08 pmol/L,P<0.001),而男孩中则保持不变;从14岁到16岁,女孩(分别为0.42±0.07 pmol/L,P<0.001)和男孩(0.64±0.07 pmol/L,P<0.001)的fT4升高。女孩的游离T3从12岁至14岁略增(增加0.07±0.03 pmol/L; P=0.042),而男孩增加更显著(0.29±0.03 pmol/L,P<0.001),然后,从14岁降至16岁,男孩和女孩均下降(女孩,0.53±0.02 pmol/L,P<0.001;男孩,0.62±0.03 pmol/L,P<0.001)。从12岁到14岁,TSH在男孩和女孩中均无显著变化,然后从14岁到16岁有所增加(女孩为4.9%,95%CI为2.4到10.3%,P=0.020;男孩为7.2%,95%CI为3.0至11.6%,P=0.001)。参考范围与成年人基本不同,特别是fT4和fT3。

由此可见,青少年甲状腺功能检查结果呈现出复杂的性别差异。实施青春期特定参考范围可能是合适的。

原始出处:

Purdey J Campbell,et al.Changes in thyroid function across adolescence: a longitudinal study.J Clin Endocrinol Metab.2019.https://doi.org/10.1210/clinem/dgz331

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    2020-07-24 smallant2015
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    2020-02-10 achengzhao
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