Pamrevlumab治疗局部晚期胰腺癌的III期临床试验正式开始

2019-10-24 Allan MedSci原创

FibroGen近日宣布,Pamrevlumab治疗不可切除的局部晚期胰腺癌(LAPC)的LAPIS III期临床研究中的首位患者已经正式接受治疗。

FibroGen近日宣布,Pamrevlumab治疗不可切除的局部晚期胰腺癌(LAPC)的LAPIS III临床研究中的首位患者已经正式接受治疗。无法切除的局部晚期胰腺癌患者面临可怕的预后,使用pamrevlumab(一种新型抗纤维化药物)可能会将肿瘤状态从无法切除变为可切除,从而有可能改善患者的预后。

FibroGen临床开发高级副总裁Elias Kouchakji医师表示:随着LAPIS研究中首位患者的入组,我们很高兴进一步推进pamrevlumab的晚期开发,将其作为局部晚期胰腺癌的治疗方法


原始出处:

http://www.firstwordpharma.com/node/1675716#axzz63E8SwRis

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    2019-11-27 freve
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encryptionId=4de7112046c, topicName=mAb)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=25e7304, createdName=snf701207, createdTime=Fri Dec 20 18:02:00 CST 2019, time=2019-12-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2088771, encodeId=6ecb2088e71c8, content=<a href='/topic/show?id=53961018913' target=_blank style='color:#2F92EE;'>#I期临床试验#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10189, encryptionId=53961018913, topicName=I期临床试验)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45b2276, createdName=839640778, createdTime=Fri Jan 03 16:02:00 CST 2020, time=2020-01-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1916179, encodeId=b49919161e9f0, content=<a href='/topic/show?id=c5a89550ff' target=_blank style='color:#2F92EE;'>#III#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9550, encryptionId=c5a89550ff, topicName=III)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e68e415, createdName=juliusluan78, createdTime=Mon Aug 03 21:02:00 CST 2020, time=2020-08-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1649482, encodeId=4bd01649482cb, content=<a href='/topic/show?id=ec7813e026a' target=_blank style='color:#2F92EE;'>#pamrevlumab#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13702, encryptionId=ec7813e026a, topicName=pamrevlumab)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d09323837847, createdName=zzc2219, createdTime=Sat Feb 29 18:02:00 CST 2020, time=2020-02-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1652950, encodeId=7dbd165295053, content=<a href='/topic/show?id=5b011018e07' target=_blank style='color:#2F92EE;'>#I期临床#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10187, encryptionId=5b011018e07, topicName=I期临床)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=fc1f24335670, createdName=医生2402, createdTime=Sat Aug 15 22:02:00 CST 2020, time=2020-08-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1957313, encodeId=66e4195e3134f, content=<a href='/topic/show?id=c87a4e6205d' target=_blank style='color:#2F92EE;'>#局部晚期胰腺癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47620, encryptionId=c87a4e6205d, topicName=局部晚期胰腺癌)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/101296147/72D57F5B3E12B2BB53D6BD015D14DCD6/100, createdBy=a92e2500162, createdName=passed water, createdTime=Thu Dec 05 20:02:00 CST 2019, time=2019-12-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1389572, encodeId=7c9e13895e279, content=<a href='/topic/show?id=82a95988106' target=_blank style='color:#2F92EE;'>#晚期胰腺癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59881, encryptionId=82a95988106, topicName=晚期胰腺癌)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/1103841572/2898B09F0DA89357D0D54A725E611AC7/100, createdBy=fdd32500040, createdName=ms7899726347904398, createdTime=Sat Oct 26 00:02:00 CST 2019, time=2019-10-26, status=1, ipAttribution=)]
    2019-12-20 snf701207
  5. 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createdBy=bccd23846580, createdName=freve, createdTime=Wed Nov 27 11:02:00 CST 2019, time=2019-11-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1650765, encodeId=f0921650e6571, content=<a href='/topic/show?id=ffae4e614b6' target=_blank style='color:#2F92EE;'>#局部晚期#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47614, encryptionId=ffae4e614b6, topicName=局部晚期)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=778d36, createdName=柳叶一刀, createdTime=Thu Jun 18 17:02:00 CST 2020, time=2020-06-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1912238, encodeId=7674191223802, content=<a href='/topic/show?id=4de7112046c' target=_blank style='color:#2F92EE;'>#mAb#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11204, 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createdBy=a92e2500162, createdName=passed water, createdTime=Thu Dec 05 20:02:00 CST 2019, time=2019-12-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1389572, encodeId=7c9e13895e279, content=<a href='/topic/show?id=82a95988106' target=_blank style='color:#2F92EE;'>#晚期胰腺癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59881, encryptionId=82a95988106, topicName=晚期胰腺癌)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/1103841572/2898B09F0DA89357D0D54A725E611AC7/100, createdBy=fdd32500040, createdName=ms7899726347904398, createdTime=Sat Oct 26 00:02:00 CST 2019, time=2019-10-26, status=1, ipAttribution=)]
  6. 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channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9550, encryptionId=c5a89550ff, topicName=III)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e68e415, createdName=juliusluan78, createdTime=Mon Aug 03 21:02:00 CST 2020, time=2020-08-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1649482, encodeId=4bd01649482cb, content=<a href='/topic/show?id=ec7813e026a' target=_blank style='color:#2F92EE;'>#pamrevlumab#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13702, encryptionId=ec7813e026a, topicName=pamrevlumab)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d09323837847, createdName=zzc2219, createdTime=Sat Feb 29 18:02:00 CST 2020, time=2020-02-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1652950, encodeId=7dbd165295053, content=<a href='/topic/show?id=5b011018e07' target=_blank style='color:#2F92EE;'>#I期临床#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10187, encryptionId=5b011018e07, topicName=I期临床)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=fc1f24335670, createdName=医生2402, createdTime=Sat Aug 15 22:02:00 CST 2020, time=2020-08-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1957313, encodeId=66e4195e3134f, content=<a href='/topic/show?id=c87a4e6205d' target=_blank style='color:#2F92EE;'>#局部晚期胰腺癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47620, encryptionId=c87a4e6205d, topicName=局部晚期胰腺癌)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/101296147/72D57F5B3E12B2BB53D6BD015D14DCD6/100, createdBy=a92e2500162, createdName=passed water, createdTime=Thu Dec 05 20:02:00 CST 2019, time=2019-12-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1389572, encodeId=7c9e13895e279, content=<a href='/topic/show?id=82a95988106' target=_blank style='color:#2F92EE;'>#晚期胰腺癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59881, encryptionId=82a95988106, topicName=晚期胰腺癌)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/1103841572/2898B09F0DA89357D0D54A725E611AC7/100, createdBy=fdd32500040, createdName=ms7899726347904398, createdTime=Sat Oct 26 00:02:00 CST 2019, time=2019-10-26, status=1, ipAttribution=)]
    2020-08-03 juliusluan78
  7. 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礼来制药公司近日表示,免疫疗法pegilodecakin治疗转移性胰腺癌患者的III期临床试验表明,未能达到其总生存期的主要终点。

Lancet Gastroen Hepatol:全球胰腺癌疾病负担研究——1990-2017

研究发现,从1990年到2017年,在全球范围内,胰腺癌导致的死亡、病例和DALYs的数量增加了一倍以上。随着人口老龄化,胰腺癌的发病率可能会继续上升。预防战略应侧重于可改变的风险因素防控

Matter:用纳米反应器对胰腺癌进行诊断

中科院大连化物所研究员刘健团队与上海交通大学研究员钱昆团队合作,将多功能氧化硅铂基纳米反应器用于胰腺癌检测, 可以同时实现代谢物的即时检测和分子分型。研究成果近日发表于《物质》。

礼来的聚乙二醇白细胞介素-10(pegilodecakin)在胰腺癌临床试验中失败

在SEQUOIA试验中,将礼来的聚乙二醇化的白细胞介素10(pegilodecakin)与标准化疗FOLFOX方案(亚叶酸、5-氟尿嘧啶和奥沙利铂)联合用于转移性胰腺癌患者的二线治疗,这些患者在基于一线吉西他滨治疗后疾病再次进展。

Cancer Res:科学家们在胰腺癌中发现了“抑癌细胞”

胰腺癌是传统抗癌药物难以治疗的一种癌症。最近,名古屋大学(Nagoya University)的研究者们发现,含有一种名为Meflin的蛋白质的细胞在抑制胰腺癌的恶化中具有重要作用。

Sci Rep:新的胰腺癌联合治疗方案可逆转肿瘤微环境!

近日,罗切斯特大学的研究人员提出了一种新的联合疗法,该疗法将一种放射疗法和一种免疫疗法结合,不仅可以治愈小鼠的胰腺癌,而且还可以重编程小鼠免疫系统,形成“免疫记忆”,产生类似肿瘤原位疫苗的治疗效果。该研究为晚期胰腺癌的临床试验设计提供了重要的指导意义。