BMC Cancer:丙泊酚和七氟醚对乳腺癌手术患者肿瘤细胞、自然杀伤细胞和细胞毒性T淋巴细胞功能的 影响:体外研究

2018-10-31 何幼芹 “罂粟花”微信号

虽然基础科学研究已经表明丙泊酚在癌症手术中可能优于挥发性药物,但在NK细胞和CTL细胞计数和包括乳腺癌细胞在内的细胞凋亡率方面,丙泊酚在乳腺癌手术麻醉过程中的作用并不优于七氟醚。

背景与目的

为了阐明麻醉药物对肿瘤免疫功能的影响,我们观察了丙泊酚和七氟醚对乳腺癌手术患者癌细胞和免疫细胞共同培养后必然杀伤(NK)细胞、细胞毒性T淋巴细胞(CTL)计数和细胞凋亡率的影响。

方  法

对接受乳腺癌手术的患者在麻醉诱导后及术后1、24 h采集静脉注射。将患者随机分为丙泊酚麻醉组和七氟醚麻醉组。我们与乳腺癌细胞共培养的方法,对两组患者的癌细胞、NK细胞和CTL细胞凋亡进行了计数和检测。我们还观察了肿瘤坏死因子-α、白细胞介素-6和?细胞介素-10在围产术期的变化。

结  果

最终的分析共包括44例患者,两实验组间NK细胞计数、CTL计数及凋亡率无明显差异。此外,在乳腺癌细胞共培养过程中,乳腺癌细胞凋亡的数量在两组间无显着差异。其次,各组间未检测到细胞因素的变化。

结  论

虽然基础科学研究已经表明丙泊酚在癌症手术中可能优于挥发性药物,但在NK细胞和CTL细胞计数和包括乳腺癌细胞在内的细胞凋亡率方面,丙泊酚在乳腺癌手术麻醉过程中的作用并不优于七氟醚。

原始出处:

Lim JA, Oh CS, Yoon T G, Lee JY,et al. The eff ect of propofol and sevoflurane on cancer cell, natural killer cell, and cytotoxic T lymphocyte function in patients undergoing breast cancer surgery: an in vitro analysis.[J]. BMC Cancer 2018 02 07 ;18(1) Randomized Controlled Trial,Research Support , Non-U.S. Gov't DOI:10.1186/s12885-018-4064-8

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