Ann Rheum Dis:人脐带间充质干细胞移植联合IFN-γ可协同改善类风湿性关节炎的临床结局

2020-06-21 xiangting MedSci原创

IFN-γ是决定MSCT对RA疗效的关键因素,MSC 联合IFN-γ治疗策略可以大大提高MSC对RA的临床疗效。

这项研究旨在阐明类风湿性关节炎(RA)患者中循环干扰素-γ(IFN-γ)的关键作用,及改善间充质干细胞(MSC)移植(MSCT)的临床疗效。

首先在胶原诱导关节炎(CIA)鼠模型中评估了野生型或IFN-γR-/- MSCT,随后对63例常规治疗无效的RA患者进行了1/2期随机对照研究。受试者被随机分为MSCT单独治疗组(n=32)或MSCT联合重组人IFN-γ治疗组(n=31),随访1年。主要终点包括疗效被评估为良好或中等EULAR应答率,以及3个月时达到美国风湿病学会20(ACR20)应答率的患者比例。

在鼠模型中,野生型MSCT可显著改善CIA的临床严重程度,而IFN-γR-/- MSCT加重滑膜炎以及关节和软骨损伤。从鼠类研究过渡到临床研究,为期3个月的随访结果显示,53.3%的MSCT单独治疗患者和93.3%的MSCT联合IFN-γ治疗患者达到了疗效和ACR20应答率(p< 0.05)。两个治疗组在1年的随访中均未出现新的或意外的安全性问题。

这项研究结果表明,IFN-γ是决定MSCT对RA疗效的关键因素,MSC 联合IFN-γ治疗策略可以大大提高MSC对RA的临床疗效。

原始出处:

Xiang Xu. Combination of human umbilical cord mesenchymal stem (stromal) cell transplantation with IFN-γ treatment synergistically improves the clinical outcomes of patients with rheumatoid arthritis. Ann Rheum Dis. June 2020.

 

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  5. 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2020, time=2020-06-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1542421, encodeId=966115424218e, content=<a href='/topic/show?id=82c0846654a' target=_blank style='color:#2F92EE;'>#脐带#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84665, encryptionId=82c0846654a, topicName=脐带)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06713409761, createdName=1249859em42(暂无昵称), createdTime=Tue Jun 23 02:27:49 CST 2020, time=2020-06-23, status=1, ipAttribution=)]
    2020-06-24 独孤立克

    干细胞是热点,但是进入临床仍然需要时间和临床疗效验证哦

    0

  6. 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2020, time=2020-06-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1542421, encodeId=966115424218e, content=<a href='/topic/show?id=82c0846654a' target=_blank style='color:#2F92EE;'>#脐带#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84665, encryptionId=82c0846654a, topicName=脐带)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06713409761, createdName=1249859em42(暂无昵称), createdTime=Tue Jun 23 02:27:49 CST 2020, time=2020-06-23, status=1, ipAttribution=)]
    2020-06-23 lmm397
  7. 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2020, time=2020-06-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1542421, encodeId=966115424218e, content=<a href='/topic/show?id=82c0846654a' target=_blank style='color:#2F92EE;'>#脐带#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84665, encryptionId=82c0846654a, topicName=脐带)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06713409761, createdName=1249859em42(暂无昵称), createdTime=Tue Jun 23 02:27:49 CST 2020, time=2020-06-23, status=1, ipAttribution=)]
  8. [GetPortalCommentsPageByObjectIdResponse(id=1843231, encodeId=0ce3184323181, content=<a href='/topic/show?id=3d052296e4e' target=_blank style='color:#2F92EE;'>#临床结局#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=22967, encryptionId=3d052296e4e, topicName=临床结局)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7fbd46, createdName=mei531, createdTime=Tue Mar 30 03:27:49 CST 2021, time=2021-03-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1658936, encodeId=413d1658936a6, content=<a href='/topic/show?id=c40ce798412' target=_blank style='color:#2F92EE;'>#细胞移植#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77984, encryptionId=c40ce798412, topicName=细胞移植)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ad4724938298, 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  9. [GetPortalCommentsPageByObjectIdResponse(id=1843231, encodeId=0ce3184323181, content=<a href='/topic/show?id=3d052296e4e' target=_blank style='color:#2F92EE;'>#临床结局#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=22967, encryptionId=3d052296e4e, topicName=临床结局)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7fbd46, createdName=mei531, createdTime=Tue Mar 30 03:27:49 CST 2021, time=2021-03-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1658936, encodeId=413d1658936a6, content=<a href='/topic/show?id=c40ce798412' target=_blank style='color:#2F92EE;'>#细胞移植#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77984, encryptionId=c40ce798412, topicName=细胞移植)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ad4724938298, 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content=<a href='/topic/show?id=55a6100826cc' target=_blank style='color:#2F92EE;'>#风湿性关节炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100826, encryptionId=55a6100826cc, topicName=风湿性关节炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5c237911872, createdName=ms1467340776200723, createdTime=Tue Jun 23 02:27:49 CST 2020, time=2020-06-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1519053, encodeId=f0c715190538e, content=<a href='/topic/show?id=ba989452f5' target=_blank style='color:#2F92EE;'>#IFN#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9452, encryptionId=ba989452f5, topicName=IFN)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=32b711235060, createdName=bugit, createdTime=Tue Jun 23 02:27:49 CST 2020, time=2020-06-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1542421, encodeId=966115424218e, content=<a href='/topic/show?id=82c0846654a' target=_blank style='color:#2F92EE;'>#脐带#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84665, encryptionId=82c0846654a, topicName=脐带)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06713409761, createdName=1249859em42(暂无昵称), createdTime=Tue Jun 23 02:27:49 CST 2020, time=2020-06-23, status=1, ipAttribution=)]
    2020-06-23 bugit
  10. 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PLX细胞是具有免疫调节特性的同种异体间充质样细胞。

Cell Death Dis:间充质干细胞通过扩增MDSCs促进癌细胞存活转移

骨髓间充质干细胞(BMSCs)是一种能分化成多种细胞类型的多能基质干细胞。 BMSCs在化学指导下作用于癌细胞,并促进癌细胞微环境的形成。 BMSC的归巢受到多种因素的影响。远处器官(特别是骨髓)扩散的肿瘤细胞(DTCs)是癌症转移和复发的来源。 DTC的存活取决于微环境。在本研究中,研究人员旨在阐明受癌症改造的BMSCs是如何促进癌细胞在原发肿瘤部位和远处存活的。研究人员通过肿瘤内BMSCs和返

JCC:间充质干细胞疗法可诱发先天性免疫记忆反应从而减轻结肠炎

间充质干细胞(MSCs)由于其免疫调节特性而被用于治疗免疫介导的疾病。MSCs的细胞疗法在免疫系统中诱导多种作用,最终导致具有调节表型的免疫细胞数量增加。

Cell Death Dis:间充质干细胞lncRNA HCP5引发脂肪酸氧化反应促进胃癌干细胞特性及耐药性

长期以来,胃癌(GC)一直是肿瘤相关死亡的首要原因,尽管手术导向的综合疗法被认为是晚期GC患者的首选,但患者术后的5年生存率仅有20%-50%。除手术外,化疗也是GC患者主要的临床治疗手段。不幸的是,

Blood:通敌叛国的间充质干细胞!竟然通过转移线粒体拯救急性淋巴白血病细胞

中心点:间充质干细胞可以转化成癌相关的成纤维细胞,并转移线粒体,从而将B-ALL细胞从ROS诱导的化疗中拯救出来。B-ALL细胞的拯救是通过微管抑制剂来完成的,微管抑制剂可阻断用于线粒体转移的隧道化纳米管。摘要:Burt等人对成人急性淋巴细胞白血病(ALL)间充质干细胞(MSC)壁龛进行研究和建模。研究人员使用基因表达谱、细胞因子/趋化因子定量、流式细胞术和多种成像技术发现,直接从ALL患者的原始

Cell Death Dis:间充质干细胞来源的外泌体或可治疗帕金森氏病

帕金森氏病(PD)是一种常见的仅次于阿尔茨海默病(AD)的第二大神经退行性疾病,导致患者的运动和认知功能障碍。在工业化国家中60岁以上的人群中其患病率约为1%。