TECHNOLOGY：支架整合微芯片助力肿瘤研究

2015-08-07 佚名生物谷

近日，来自麻省总医院等处的研究人员通过研究设计了一种新型的微芯片，其可以通过将3D的水凝胶支架整合入流体设备中，来回收吸附在微流体设备上的癌细胞进行体内或体外分析，相关研究发表于国际杂志TECHNOLOGY上。循环中的肿瘤细胞被认为是转移性的前体细胞，其可以引发90%以上的癌症相关的死亡；微流体设备可以通过患者的血液样本轻松捕获罕见的循环肿瘤细胞，临床研究表明，循环肿瘤细胞的数量和病人的预后

近日，来自麻省总医院等处的研究人员通过研究设计了一种新型的微芯片，其可以通过将3D的水凝胶支架整合入流体设备中，来回收吸附在微流体设备上的癌细胞进行体内或体外分析，相关研究发表于国际杂志TECHNOLOGY上。

循环中的肿瘤细胞被认为是转移性的前体细胞，其可以引发90%以上的癌症相关的死亡；微流体设备可以通过患者的血液样本轻松捕获罕见的循环肿瘤细胞，临床研究表明，循环肿瘤细胞的数量和病人的预后存在直接关系。测定循环肿瘤细胞的数量或许就可以帮助理解患者机体的肿瘤状态并且为开发新型个体化疗法提供帮助。

微粒体设备捕获的肿瘤细胞在不破坏细胞生理特性的情况下非常难以利用设备进行回收。这项研究中，研究者描述了一种简单有效的策略来将3D水凝胶基底物整合入微粒体设备中，以使得肿瘤细胞被捕获后可以被快速回收；研究者利用了水凝胶结构的固有属性，使其可以经历持续性地在水合和脱水状态下转换，而包含前列腺肿瘤细胞的细胞悬液可以被用于证实癌细胞是否会吸附到这种水凝胶基质上，因此这种细胞支架基质就可以很容易地被设备回收，从而使得癌细胞可以在体外的促生长实验中可见，而肿瘤支架被植入免疫缺陷的小鼠机体后就可以成功开发出配对的异种移植物模型。

最后研究者Jungwoo Lee博士说道，利用微芯片的特异性捕获及高通量特性，我们希望利用患者的标本进行新一代设备的检测，来证实该方法和临床治疗的关联性。循环肿瘤细胞的配对模型可以帮助进行实际的实验来获取癌细胞新型的突变及对药物的敏感性，本文研究为后期开发新型设备来进行癌症发病机制的研究提供了新的线索。

原文出处：

Jungwoo Lee,Nathaniel Kohl.et al.Scaffold-integrated microchips for end-to-end in vitro tumor cell attachment and xenograft formation.TECHNOLOGY.2015

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2017-06-07 laoli

学习了，谢谢分享！

61 0
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2015-08-08 fzwish20000

#Technology#

28 0
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2015-12-20 shock_melon

#TEC#

36 0
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2016-01-10 lyh994

漂亮！

114 0
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2015-10-12 hlycom3356

这篇文章写的很好

110 0
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2015-10-12 hlycom3356

这篇文章写的很好

114 0
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2015-10-12 hlycom3356

这篇文章写的很好

107 0
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2015-10-12 hlycom3356

这篇文章写的很好

75 0
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2015-10-12 hlycom3356

这篇文章写的很好

88 0
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2015-10-11 hlycom3356

感谢作者分享

73 0

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