Ann Intern Med:45项研究Meta分析:早期慢性肾病患者应优选新型抗凝药物

2019-07-17 xujing 中国循环杂志

根据发表在《内科学年鉴》上的研究结果,在早期慢性肾病患者中,新型抗凝药物的获益高于华法林。

根据发表在《内科学年鉴》上的研究结果,在早期慢性肾病患者中,新型抗凝药物的获益高于华法林。

研究者分析了评估新型抗凝药物和华法林效果的45项试验,涉及34082名参与者。

研究人员发现,在房颤和早期慢性肾病患者中,与华法林相比新型抗凝药物降低了中风或全身性栓塞(RR=0.79)和出血性中风(RR=0.48)的风险。

与华法林相比,新型抗凝药物对复发性静脉血栓栓塞或静脉血栓栓塞相关死亡的影响是不确定的(RR=0.72)。

在所有的试验中,与华法林相比,新型抗凝药物似乎降低了大出血的风险(RR=0.75)。

此外,并无足够的证据来支持晚期慢性肾病和透析的终末期肾病患者使用华法林或新型抗凝药物。

原始出处:Jeffrey T. Ha, MBBS; Brendon L. Neuen, MBBS(Hons); Lap P. Cheng, MBBS; et al. Benefits and Harms of Oral Anticoagulant Therapy in Chronic Kidney Disease: A Systematic Review and Meta-analysis. Ann Intern Med. 16 JULY 2019

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    2020-01-25 一闲
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    2020-05-05 guojianrong
  6. [GetPortalCommentsPageByObjectIdResponse(id=2025868, encodeId=25ff2025868b8, content=<a href='/topic/show?id=a91d82583bf' target=_blank style='color:#2F92EE;'>#肾病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82583, encryptionId=a91d82583bf, topicName=肾病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=db5b227, createdName=gostraight, createdTime=Fri Jan 17 22:18:00 CST 2020, time=2020-01-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2055972, encodeId=87dd20559e2ef, content=<a href='/topic/show?id=d088536467a' target=_blank style='color:#2F92EE;'>#慢性肾病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53646, encryptionId=d088536467a, topicName=慢性肾病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=568152, createdName=snowpeakxu, createdTime=Fri Mar 27 11:18:00 CST 2020, time=2020-03-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1998528, encodeId=5e16199852824, content=<a href='/topic/show?id=efbf5822950' target=_blank style='color:#2F92EE;'>#新型抗凝药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58229, encryptionId=efbf5822950, topicName=新型抗凝药)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3609256, createdName=zhu_jun9837, createdTime=Tue Apr 14 16:18:00 CST 2020, time=2020-04-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1896519, encodeId=9096189651916, content=<a href='/topic/show?id=4a391158248' target=_blank style='color:#2F92EE;'>#MET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11582, encryptionId=4a391158248, topicName=MET)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=18fc139, createdName=一闲, createdTime=Sat Jan 25 20:18:00 CST 2020, time=2020-01-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1888038, encodeId=cb8d1888038e4, content=<a href='/topic/show?id=d56611584ec' target=_blank style='color:#2F92EE;'>#Meta#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11584, encryptionId=d56611584ec, topicName=Meta)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d8f4110, createdName=guojianrong, createdTime=Tue May 05 07:18:00 CST 2020, time=2020-05-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=369980, encodeId=4dc43699805c, content=注意身体, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/07/13/c48064d3b7f86e87115574719fd684e6.jpg, createdBy=814a5140228, createdName=jefflin520, createdTime=Sat Jul 20 09:00:17 CST 2019, time=2019-07-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=369927, encodeId=d60436992e84, content=其实更想知道终末期慢性肾脏病抗凝怎么选, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=23d31320043, createdName=guanchenan, createdTime=Fri Jul 19 08:13:52 CST 2019, time=2019-07-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1609868, encodeId=11bf1609868cc, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Thu Jul 18 18:18:00 CST 2019, time=2019-07-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=369816, encodeId=2c9d3698168a, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1bb241978, createdName=phoebeyan520, createdTime=Wed Jul 17 10:23:53 CST 2019, time=2019-07-17, status=1, ipAttribution=)]
    2019-07-20 jefflin520

    注意身体

    0

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    2019-07-19 guanchenan

    其实更想知道终末期慢性肾脏病抗凝怎么选

    0

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    2019-07-17 phoebeyan520

    学习了

    0

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