Clinica Chimica Acta:血浆代谢物黄嘌呤、4-吡哆酸和d-谷氨酸作为新的肺结核生物标志物

2019-12-02 gladiator MedSci原创

目前,一直缺乏快速和有效的诊断结核病方法,这也是控制该疾病流行的挑战之一。这项研究的目的是识别新的非侵入性肺结核生物标志物。

目前,一直缺乏快速和有效的诊断结核病方法,这也是控制该疾病流行的挑战之一。这项研究的目的是识别新的非侵入性肺结核生物标志物。

本研究将研究对象分为4组,肺结核组、社区获得性肺炎(CAP)组、肺癌(LC)组和正常对照组(NC)。采用超高效液相色谱- Q质谱联用技术研究各组血浆小分子代谢物。采用多元统计方法和生物信息学方法对数据进行分析。

研究发现,与其他组相比,肺结核组有三种不同的血浆代谢物,如黄嘌呤、4-吡哆酸和d-谷氨酸(CAPLCNC)。通路富集分析表明,肺结核的能量来源是多中心的,可能与维持结核分枝杆菌的繁殖能力和毒力有关。

研究结果表明,黄嘌呤、4-吡啶甲酸和d-谷氨酸可能是肺结核的潜在生物标志物。本研究为开发肺结核潜在的生物标志物提供了实验依据。

原始出处:

Huai HuangLi-Ying ShiPlasma metabolites Xanthine, 4-Pyridoxate, and d-glutamic acid as novel potential biomarkers for pulmonary tuberculosis

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    2020-02-15 windight
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GetPortalCommentsPageByObjectIdResponse(id=1560870, encodeId=e64915608e074, content=<a href='/topic/show?id=3c746936567' target=_blank style='color:#2F92EE;'>#生物标志#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69365, encryptionId=3c746936567, topicName=生物标志)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=63db15173977, createdName=zhu_jun9842, createdTime=Wed Dec 04 13:07:00 CST 2019, time=2019-12-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1566879, encodeId=acc515668e9c3, content=<a href='/topic/show?id=3c746936567' target=_blank style='color:#2F92EE;'>#生物标志#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69365, encryptionId=3c746936567, topicName=生物标志)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=63db15173977, createdName=zhu_jun9842, createdTime=Wed Dec 04 13:07:00 CST 2019, time=2019-12-04, status=1, ipAttribution=)]
    2020-02-14 cenghis
  5. 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  6. 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  7. 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  8. 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  9. 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