Graefes Arch Clin Exp Ophthalmol:玻璃体内注射贝伐单抗治疗可减少早产儿视网膜病变中的眼部血流

2018-07-14 cuiguizhong MedSci原创

日本东京大学医学部眼科的Matsumoto T近日在Graefes Arch Clin Exp Ophthalmol发表了一篇文章,他们研究了眼部血流量、激光散斑流动图的平均模糊率(MBR)以及玻璃体内贝伐单抗(IVB)治疗早产儿视网膜病变(ROP)之间的关系。

日本东京大学医学部眼科的Matsumoto T近日在Graefes Arch Clin Exp Ophthalmol发表了一篇文章,他们研究了眼部血流量、激光散斑流动图的平均模糊率(MBR)以及玻璃体内贝伐单抗(IVB)治疗早产儿视网膜病变(ROP)之间的关系。

这是一项病例系列研究,对4名新生儿进行静脉注射IVB,并在注射前后评估8只眼的状况,循环连续测量3次。我们在治疗前和治疗后1周,分别进行了视神经乳头血流测量和荧光血管造影(FA)检测。分别针对MBR-A(所有值的平均值)、MBR-V(血管平均值)和MBR-T(组织平均值)分析血流情况。使用配对t检验进行治疗前后MBR(-A,-V,-T)、体重和其他全身和眼部参数的比较。

结果他们发现,在所有情况下,IVB治疗后的MBR的值显着低于治疗前的值。所有眼睛在治疗前均显示FA上存在新血管产生时造成的渗漏。虽然治疗后1周渗漏得到改善,但新血管形成的症状并未完全消退。

因此,他们认为,IVB可改善静脉扩张和动脉迂曲,同时减少ROP新生儿的眼部血流量,同时作者指出,IVB治疗早期的眼部血流减少并不能影响新生血管形成过程。

原文出处:

Matsumoto, T., et al., Intravitreal bevacizumab treatment reduces ocular blood flow in retinopathy of prematurity: a four-case report. Graefes Arch Clin Exp Ophthalmol, 2018.

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createdBy=05a2499, createdName=dzx0922889, createdTime=Tue May 14 09:27:00 CST 2019, time=2019-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1800713, encodeId=75841800e137a, content=<a href='/topic/show?id=25d3e293521' target=_blank style='color:#2F92EE;'>#眼部血流#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72935, encryptionId=25d3e293521, topicName=眼部血流)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d8f4110, createdName=guojianrong, createdTime=Sat Dec 01 17:27:00 CST 2018, time=2018-12-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1776072, encodeId=fd1f1e76072c9, content=<a href='/topic/show?id=508ae2913d6' target=_blank style='color:#2F92EE;'>#眼部#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, 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objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90782, encryptionId=27b290e82f4, topicName=视网膜病变)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f7143034078, createdName=zhanfl, createdTime=Mon Jul 16 13:27:00 CST 2018, time=2018-07-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1477025, encodeId=b96f14e70255d, content=<a href='/topic/show?id=c32e9220221' target=_blank style='color:#2F92EE;'>#贝伐#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=92202, encryptionId=c32e9220221, topicName=贝伐)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ef557344179, createdName=sunrural_42825359, createdTime=Mon Jul 16 13:27:00 CST 2018, time=2018-07-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1496233, encodeId=c6d31496233ee, content=<a href='/topic/show?id=bab46858ee3' target=_blank style='color:#2F92EE;'>#玻璃体#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=68587, encryptionId=bab46858ee3, topicName=玻璃体)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=47bd9248134, createdName=yykkxiaodou, createdTime=Mon Jul 16 13:27:00 CST 2018, time=2018-07-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1541369, encodeId=68e41541369aa, content=<a href='/topic/show?id=5c961e37307' target=_blank style='color:#2F92EE;'>#THA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17373, encryptionId=5c961e37307, topicName=THA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=615b13300589, createdName=1249842em13(暂无昵称), createdTime=Mon Jul 16 13:27:00 CST 2018, time=2018-07-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1543169, encodeId=abb01543169c5, content=<a href='/topic/show?id=d8d6592e21d' target=_blank style='color:#2F92EE;'>#早产儿视网膜病变#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59272, encryptionId=d8d6592e21d, topicName=早产儿视网膜病变)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d29113549501, createdName=396094184_42047359, createdTime=Mon Jul 16 13:27:00 CST 2018, time=2018-07-16, status=1, ipAttribution=)]
    2019-04-19 huiwelcome
  5. [GetPortalCommentsPageByObjectIdResponse(id=1745753, encodeId=14541e45753cd, content=<a href='/topic/show?id=79ab685899e' target=_blank style='color:#2F92EE;'>#玻璃体内注射#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=68589, encryptionId=79ab685899e, topicName=玻璃体内注射)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6da635562893, createdName=cathymary, createdTime=Mon Jun 24 16:27:00 CST 2019, time=2019-06-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2053643, encodeId=dc36205364327, content=<a href='/topic/show?id=e8646858880' target=_blank style='color:#2F92EE;'>#玻璃体内#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=68588, encryptionId=e8646858880, topicName=玻璃体内)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=05a2499, createdName=dzx0922889, createdTime=Tue May 14 09:27:00 CST 2019, time=2019-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1800713, encodeId=75841800e137a, content=<a href='/topic/show?id=25d3e293521' target=_blank style='color:#2F92EE;'>#眼部血流#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72935, encryptionId=25d3e293521, topicName=眼部血流)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d8f4110, createdName=guojianrong, createdTime=Sat Dec 01 17:27:00 CST 2018, time=2018-12-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1776072, encodeId=fd1f1e76072c9, content=<a href='/topic/show?id=508ae2913d6' target=_blank style='color:#2F92EE;'>#眼部#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, 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objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90782, encryptionId=27b290e82f4, topicName=视网膜病变)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f7143034078, createdName=zhanfl, createdTime=Mon Jul 16 13:27:00 CST 2018, time=2018-07-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1477025, encodeId=b96f14e70255d, content=<a href='/topic/show?id=c32e9220221' target=_blank style='color:#2F92EE;'>#贝伐#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=92202, encryptionId=c32e9220221, topicName=贝伐)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ef557344179, createdName=sunrural_42825359, createdTime=Mon Jul 16 13:27:00 CST 2018, time=2018-07-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1496233, encodeId=c6d31496233ee, content=<a href='/topic/show?id=bab46858ee3' target=_blank style='color:#2F92EE;'>#玻璃体#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=68587, encryptionId=bab46858ee3, topicName=玻璃体)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=47bd9248134, createdName=yykkxiaodou, createdTime=Mon Jul 16 13:27:00 CST 2018, time=2018-07-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1541369, encodeId=68e41541369aa, content=<a href='/topic/show?id=5c961e37307' target=_blank style='color:#2F92EE;'>#THA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17373, encryptionId=5c961e37307, topicName=THA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=615b13300589, createdName=1249842em13(暂无昵称), createdTime=Mon Jul 16 13:27:00 CST 2018, time=2018-07-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1543169, encodeId=abb01543169c5, content=<a href='/topic/show?id=d8d6592e21d' target=_blank style='color:#2F92EE;'>#早产儿视网膜病变#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59272, encryptionId=d8d6592e21d, topicName=早产儿视网膜病变)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d29113549501, createdName=396094184_42047359, createdTime=Mon Jul 16 13:27:00 CST 2018, time=2018-07-16, status=1, ipAttribution=)]
    2018-07-16 zutt
  6. [GetPortalCommentsPageByObjectIdResponse(id=1745753, encodeId=14541e45753cd, content=<a href='/topic/show?id=79ab685899e' target=_blank style='color:#2F92EE;'>#玻璃体内注射#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=68589, encryptionId=79ab685899e, topicName=玻璃体内注射)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6da635562893, createdName=cathymary, createdTime=Mon Jun 24 16:27:00 CST 2019, time=2019-06-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2053643, encodeId=dc36205364327, content=<a href='/topic/show?id=e8646858880' target=_blank style='color:#2F92EE;'>#玻璃体内#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=68588, encryptionId=e8646858880, topicName=玻璃体内)], attachment=null, authenticateStatus=null, createdAvatar=, 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createdTime=Mon Jul 16 13:27:00 CST 2018, time=2018-07-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1543169, encodeId=abb01543169c5, content=<a href='/topic/show?id=d8d6592e21d' target=_blank style='color:#2F92EE;'>#早产儿视网膜病变#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59272, encryptionId=d8d6592e21d, topicName=早产儿视网膜病变)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d29113549501, createdName=396094184_42047359, createdTime=Mon Jul 16 13:27:00 CST 2018, time=2018-07-16, status=1, ipAttribution=)]
  7. [GetPortalCommentsPageByObjectIdResponse(id=1745753, encodeId=14541e45753cd, content=<a href='/topic/show?id=79ab685899e' target=_blank style='color:#2F92EE;'>#玻璃体内注射#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=68589, encryptionId=79ab685899e, topicName=玻璃体内注射)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6da635562893, createdName=cathymary, createdTime=Mon Jun 24 16:27:00 CST 2019, time=2019-06-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2053643, encodeId=dc36205364327, content=<a href='/topic/show?id=e8646858880' target=_blank style='color:#2F92EE;'>#玻璃体内#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=68588, encryptionId=e8646858880, topicName=玻璃体内)], attachment=null, authenticateStatus=null, createdAvatar=, 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荷兰鹿特丹眼科医院的Mulder VC近日在Ophthalmologica发表了一篇文章,他们测量了孔源性视网膜脱离(RRD)患者的玻璃体和视网膜下部液体(SRF)中凝血酶原片段(F1 + 2)和凝血酶-抗凝血酶复合物(TAT)的活性,并进一步证实了他们较早之前发现的增生性玻璃体视网膜病变(PVR)患者中凝血酶活性上升。

Retina:玻璃体视网膜病变患者进行气压性视网膜固定手术结果!

加州大学戴维斯分校眼科与视觉科学系的Emami-Naeini P近日在Retina发表了他们的一项工作,他们对进行过气压性视网膜固定手术的玻璃体视网膜病变患者,进行手术后解剖和视力结果研究。

BMJ Case Rep:玻璃体内贝伐单抗用于治疗黄热病性视网膜炎:一种新的解决黄斑水肿的方法

印度新德里全印度医学研究所眼科科学中心的Chawla R近日在BMJ Case Rep发表了一项重要的工作,认为贝伐单抗是治疗继发于视网膜炎的黄斑水肿的安全有效药物。

Ophthalmologica:玻璃体腔内注射曲安奈德与白内障手术联合治疗效果评估

日本东京女子医科大学东京医学中心眼科的Nunome T近日在Ophthalmologica发表了一篇文章,他们在抗血管内皮生长因子(抗VEGF)治疗的糖尿病性黄斑水肿(DME)患者中,评估玻璃体内注射曲安奈德注射液(IVTA)联合白内障手术治疗方法的有效性。

Invest Ophthalmol Vis Sci:Fc区域对抗VEGF药物在玻璃体半衰期中的作用!

韩国首尔国立大学医学院眼科系的Joo K近日在Invest Ophthalmol Vis Sci杂志发表了一篇文章,他们研究了可结晶的片段(Fc)在眼内蛋白药物药代动力学中的作用。