Molecules:石斛中Moscatilin可用于治疗头颈部鳞状细胞癌

2020-02-23 MedSci MedSci

Dendrobii Herba是一种使用铁皮石species种(Orchidacea)茎的草药。传统上,它已用于治疗发烧,水症,胃病和肌萎缩。在我们先前的研究中,从Dendrobii Herba中分离出的联苄化合物Moscatilin对FaDu人咽鳞状细胞癌细胞系显示出强大的细胞毒性。这一发现促使我们在FaDu细胞中进行了其他研究,以研究其作用机理。 结果显示,Moscatilin通过使用5μM的

Dendrobii Herba是一种使用铁皮石斛,以茎入药的草药。传统上,它已用于治疗发烧,水肿,病和肌萎缩。在我们先前的研究中,从Dendrobii Herba中分离出的联苄化合物杓唇石斛素(Moscatilin)对人咽鳞状细胞癌细胞系FaDu细胞显示出强大的细胞毒性。这一发现促使我们在FaDu细胞中进行了其他研究,以研究其作用机理。

结果显示,Moscatilin通过使用5μM的浓度和介导凋亡来诱导FaDu细胞死亡,而用1μM的Moscatilin处理后的细胞增殖并未被抑制到与抗癌药顺铂相同的水平。通过与5μM的Moscatilin处理可以增加凋亡相关蛋白的表达(裂解的caspase-8,裂解的caspase-7,细胞色素c,裂解的caspase-9,裂解的caspase-3和聚(ADP-核糖)聚合酶(PARP)。这表明,moscatilin介导的细胞凋亡与外在和内在的凋亡信号通路相关;此外,moscatilin诱导的凋亡是由c-Jun N端激酶(JNK)信号通路介导的。

综上所述,该研究结果表明,Moscatilin可作为化学治疗剂在头颈部鳞状细胞癌治疗中的潜在药物。

原始出处:

Lee E, Han AR, et al., Moscatilin Induces Apoptosis in Human Head and Neck Squamous Cell Carcinoma Cells via JNK Signaling Pathway. Molecules. 2020 Feb 18;25(4). pii: E901. doi: 10.3390/molecules25040901.

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