J Craniofac Surg:维生素E可促进牵张成骨中的骨形成

2019-06-30 不详 网络

牵张成骨(DO)的长期巩固期可能导致疼痛,感染,骨折,瘢痕形成,畸形愈合和延迟愈合等并发症。本研究旨在评估下颌骨DO期间全身维生素E应用对兔模型新骨再生的影响。 选择16只成年雄性8月龄的新西兰兔用牵引器进行下颌骨延长研究。在5天的潜伏期后,以0.5mm / 12小时的速率激活牵开器,持续7天。从手术开始,实验动物腹膜内接受200mg / kg的α-生育酚注射7天。在30天的巩固期后,处死兔子。获

牵张成骨(DO)的长期巩固期可能导致疼痛,感染,骨折,瘢痕形成,畸形愈合和延迟愈合等并发症。本研究旨在评估下颌骨DO期间全身维生素E应用对兔模型新骨再生的影响。

选择16只成年雄性8月龄的新西兰兔用牵引器进行下颌骨延长研究。在5天的潜伏期后,以0.5mm / 12小时的速率激活牵开器,持续7天。从手术开始,实验动物腹膜内接受200mg / kg的α-生育酚注射7天。在30天的巩固期后,处死兔子。获得加长的下颌骨并进行双能X射线吸收测定(DXA),放射学和组织形态学分析。

结果显示,在DXA分析期间,实验组中的骨矿物质密度和骨矿物质含量值铭心高于对照组。与对照组相比,实验组的兔在成骨细胞,破骨细胞,血管数和新形成的骨区域方面具有统计学上更高的分数。

总之,本研究的结果表明,在DO期间施用全身性维生素E可以刺激兔子中的新骨形成,从而缩短治疗时间。

原始出处:

Akçay H, Kuru K, et al., Vitamin E Promotes Bone Formation in a Distraction Osteogenesis Model. J Craniofac Surg. 2019 Jun 20. doi: 10.1097/SCS.0000000000005685.

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    2019-07-02 zhaojie88
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    2019-07-01 龙胆草

    学习谢谢分享

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    2019-07-01 122e052cm96暂无昵称

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