BMJ:接受激素治疗的变性人群患乳腺癌风险

2019-05-16 xing.T 网络

由此可见,该研究显示,与正常男性相比,变性女性患乳腺癌的风险增加,与正常女性相比,变性男性的风险更低。在变性女性中,在相对较短的激素治疗期间乳腺癌的风险增加,并且乳腺癌的特征类似于女性。这些结果表明,对于使用激素治疗的变性人来说,正常人群的乳腺癌筛查指南足以。

近日,顶级杂志BMJ上发表了一篇研究文章,研究人员旨在调查荷兰变性人乳腺癌的发病率和特征,并与一般荷兰人群进行比较。

该研究在荷兰阿姆斯特丹专门三级性别诊所进行的回顾性全国性队列研究。参与者为2260名成年变性女性(出生时为男性)和1229名成年变性男性(出生时为女性)接受性别激素治疗。该研究主要结果指标为变性人乳腺癌的发病率和特征(如组织学、激素受体状态)。 

该队列的总人数为变性女性为33991人次每年,变性男性为14883人次每年。在队列中的2260名变性女性中,确定了15例浸润性乳腺癌(激素治疗的中位持续时间为18年,范围为7-37年)。这比正常男性高46倍(标准化发病率46.7,95%置信区间27.2至75.4),但低于正常女性(0.3,0.2至0.4)。大多数肿瘤来自导管,雌激素和孕激素受体阳性,8.3%是人表皮生长因子2(HER2)阳性。在1229名变性男性中,确定了4例浸润性乳腺癌(激素治疗的中位持续时间为15年,范围为2-17年)。与正常女性相比,这低于预期(标准化发病率为0.2,95%可信区间为0.1至0.5)。 

由此可见,该研究显示,与正常男性相比,变性女性患乳腺癌的风险增加,与正常女性相比,变性男性的风险更低。在变性女性中,在相对较短的激素治疗期间乳腺癌的风险增加,并且乳腺癌的特征类似于女性。这些结果表明,对于使用激素治疗的变性人来说,正常人群的乳腺癌筛查指南足以。 

原始出处:


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    2020-03-29 gaoxiaoe
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    2019-12-02 sjq027
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    2019-05-17 huangdf
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    2019-05-16 龙胆草

    学习谢谢分享

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糖尿病大量蛋白尿,为何还要用激素治疗?

一个47岁男性,6年前查体发现血糖升高而住院治疗,出院后间断服用降糖药,空腹血糖维持在7mmol/L上下,餐后2小时血糖维持在10mmol/L上下,血压基本正常。

JCO:激素治疗耐药后的新选择——依维莫司增强氟维司群在AI-抵抗、ER阳性的转移性乳腺癌中的疗效

内分泌治疗一定程度上延长了乳腺癌患者的生存,但有一部分患者会产生耐药,使其临床获益相当低。PrE0102研究发现mTOR通路抑制剂的使用可以改善这一情况。本研究旨在探索氟维司群这一雌激素受体阻滞剂联合mTOR通路抑制剂依维莫司对比安慰剂在AI耐药患者中的疗效。

J Clin Oncol:激素治疗可导致乳腺癌幸存者患糖尿病风险增加?

2018年7月,发表于《J Clin Oncol》上的一项病例队列研究,考察了激素治疗对乳腺癌幸存者患糖尿病风险的影响。