PNAS:卢煜明团队PNAS发表新成果,在母体血浆中发现环状DNA

2020-01-09 不详 转化医学网

香港中文大学卢煜明(Dennis Lo)教授领导的研究团队,近日从孕妇血浆中鉴定出母亲和胎儿的环状游离DNA,为无创产前检测提供了一种新型的生物标志物。这项成果于1月3日发表在PNAS上。

香港中文大学卢煜明(Dennis Lo)教授领导的研究团队,近日从孕妇血浆中鉴定出母亲和胎儿的环状游离DNA,为无创产前检测提供了一种新型的生物标志物。这项成果于1月3日发表在PNAS上。



早在十年前,卢煜明教授就发现,利用母体的血浆样本能够获得胎儿的全基因组图谱,这项重要的成果成为无创产前检测(NIPT)的里程碑。

不过,之前的研究主要是基于线性DNA片段。尽管在小鼠血浆中曾观察到染色体外环状DNA(eccDNA),但尚未在孕妇血浆中检测到这种分子。

卢煜明及其同事此次从孕妇血浆中分离出eccDNA分子并开展测序,证实了胎儿eccDNA在孕妇血浆中的存在,强调了血浆DNA的拓扑分析,这是循环核酸研究和应用的新兴方向。

此外,母体血浆中的eccDNA具有较强的生物稳定性和独特的分子特征。卢煜明教授表示:“对于未来的研究来说,探索不同的妊娠相关疾病(如子痫前期和早产)中孕妇血浆eccDNA谱的潜在异常将是十分有趣的。”

原始出处:

Sarah T. K. Sin, Peiyong Jiang, Jiaen Deng, et.al. Identification and characterization of extrachromosomal circular DNA in maternal plasma. PNAS  January 3, 2020

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    2020-06-17 drwjr
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    2020-06-20 wgx306
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