J Endod:非侵袭性内皮功能及亚临床血管粥样硬化评估分析根尖周炎和心血管疾病之间的关系

2019-05-15 lishiting MedSci原创

牙髓来源的慢性感染可能会诱发心血管疾病(CVD)的发生。关于描述根尖周炎(AP)和心血管疾病之间关系的研究很少,而对二者之间的联系更是存在相反的看法。同样,检测标志物价格昂贵,使其很难应用于一般医疗当中。这篇研究的目的是通过非侵袭性方法(ie, 流动介导的膨胀[FMD]和颈动脉血管内膜调节厚度[c-IMT])检测AP和CVD之间是否存在联系。

牙髓来源的慢性感染可能会诱发血管疾病(CVD)的发生。关于描述根尖周炎(AP)和血管疾病之间关系的研究很少,而对二者之间的联系更是存在相反的看法。同样,检测标志物价格昂贵,使其很难应用于一般医疗当中。这篇研究的目的是通过非侵袭性方法(ie, 流动介导的膨胀[FMD]和颈动脉血管内膜调节厚度[c-IMT])检测AP和CVD之间是否存在联系。

这项横断面研究纳入了120名年龄在20-40岁未见牙周疾病、CVD和常规心血管风险因素的男性;60名受试者存在AP,60名为对照组。所有受试者均进行了身体和口腔检查、超声心动描述术、FMD对右侧肱动脉的超声评估和c-IMT。数据使用Mann-Whitney U检验和Spearman rank correlation (rs)检验进行统计学评估。

结果显示,与健康对照相比(mean = 9.74% ± 2.59%, P = .000),AP患者的FMD损伤显著(mean = 4.9% ± 2.05%)。c-IMT检测也显示AP (mean = 0.64 ± 0.12 mm)和对照组(mean = 0.54 ± 0.08 mm)之间存在显著性差异(P = .000)。c-IMT 和FMD之间存在负相关性(rs = -0.381, P = .000)。

结论:AP受试者FMD受损以及c-IMT增强表明牙髓感染与CVD存在一定的联系。

原始出处:

Chauhan N, Mittal S, et al. Association of Apical Periodontitis With Cardiovascular Disease via Noninvasive Assessment of Endothelial Function and Subclinical Atherosclerosis. J Endod. 2019 Apr 25. pii: S0099-2399(19)30207-9. doi: 10.1016/j.joen.2019.03.003.

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    2019-05-17 sunyl07
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    2019-05-16 jingjing

    大家一般关心疾病,但是亚临床更重要,这是疾病防控方向的前移,各类疾病都是这样。如亚临床甲减,亚临床心肌损伤,亚临床心衰等

    0

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