Sci Rep:过敏性鼻炎是胃食管反流病的一种风险因素

2019-11-14 AlexYang MedSci原创

胃食管反流病(GERD)能够引起一些上呼吸道症状,并改变鼻咽粘膜的生理,而反过来上呼吸道疾病同样可能加剧GERD症状。长久以来,哮喘被认为是GERD的一种风险因素。根据相似的流行病学与病理生理学,哮喘和过敏性鼻炎(AR)通常被鉴定为联合气道疾病;然而,AR与GERD的相关性仍旧还没有阐明。最近,有研究人员评估了是否AR能够增加GERD的风险。研究人员从健康保险数据库中鉴定了诊断为AR的患者,时间为

食管反流病(GERD)能够引起一些上呼吸道症状,并改变鼻咽粘膜的生理,而反过来上呼吸道疾病同样可能加剧GERD症状。长久以来,哮喘被认为是GERD的一种风险因素。根据相似的流行病学与病理生理学,哮喘和过敏性鼻炎(AR)通常被鉴定为联合气道疾病;然而,AR与GERD的相关性仍旧还没有阐明。

最近,有研究人员评估了是否AR能够增加GERD的风险。研究人员从健康保险数据库中鉴定了诊断为AR的患者,时间为2000年1月1日和2005年12月31日,他们均没有食管反流病历史。研究人员关注的是新发的GERD。研究人员利用Cox回归模型计算了GERD的风险比(HR)。研究人员共分析了193810名年龄不小于18岁的AR患者数据,他们在基线时间点无AR。研究发现,AR群体(n=96905)比非AR群体(n=96905)具有显著更高的GERD风险(调整后HR (aHR) 1.94; 95% CI=1.88-1.99, p<0.001)。

最后,研究人员指出,AR可能比哮喘更强的与GERD的相关性,尽管哮喘与AR可能通过一些共有的途径来增加GERD的风险。

原始出处:


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    2019-11-16 zhouqu_8
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    2019-11-16 feifers
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    2019-11-15 14794e5bm67(暂无昵称)

    学习了,不错的话题,非常精彩,受益非浅

    0

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导致呼出一氧化氮(FeNO)水平变化的相关因素在不同年龄段的哮喘儿童中仍具缺乏报道。最近,有研究人员在具有过敏性鼻炎的哮喘儿童中评估了与FeNO相关的因素和FeNO对吸入性类固醇的响应情况。研究包括了5岁到12岁的哮喘儿童。研究人员测试了FeNO、肺功能和对乙酰甲胆硷的支气管高反应性(BHR)、气源性过敏原的皮刺测试、血清中总免疫球蛋白E(T-lgE)和血液中的嗜酸性粒细胞水平,并评估了FeNO与

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与老龄化相关疾病的患病率正在增加,其中就有鼻部的问题。慢性鼻炎是老年人中最为常见的鼻部疾病之一。同时,过敏症状会因免疫退化而减少。最近,有研究人员评估了一种皮质类固醇鼻喷雾剂(糠酸莫米松)对鼻腔开放和鼻炎严重度以及生活质量的影响,并与生理盐水喷雾效果进行了比较。研究是一个开放标签随机研究,包括了不小于60岁的慢性鼻炎(过敏性和非过敏性鼻炎)患者。主要的终点是鼻腔开放的改善,次级结果包括了症状的严重

Mol Med Rep:Der p2‑A20 DNA疫苗能够减弱过敏性炎症

过敏性鼻炎(AR)是一种常见的疾病,需要更加方便,安全和有效的抗原特异性免疫疗法。最近,有研究人员调查了鼻内注射能够共表达der p2和a20蛋白的真核表达载体对过敏性鼻炎小鼠的治疗效果。研究人员通过纳米粒子包装pVAX1-Der p2-A20疫苗,并通过建立了Balb/c过敏性鼻炎小鼠模型。之后评估了DNA疫苗对鼻过敏炎症的治疗效果,并通过ELISA确定了lgE,slgE和lgG以及细胞因子水平

盘点:鼻炎的治疗进展

【1】Clin Otolaryngol:鼻用中药软膏Biyeom-go治疗鼻炎相关鼻症状的前瞻性观察研究 https://www.ncbi.nlm.nih.gov/pubmed/31468673最近,有研究人员调查了Biyeom-go在治疗鼻炎相关鼻症状中的效果和临床可行性情况。研究是一个前瞻性的观察性研究。研究包括了58名患有鼻炎的患者。所有的患者均接受每天大于3次的Biyeom-go治

Int Forum Allergy Rhinol:类胆碱能神经元D-U87细胞能估促进过敏性鼻炎T辅助细胞2的极化

副交感神经过敏对过敏性鼻炎(AR)的严重度是有贡献的,但是潜在的神经免疫调控的精细机制仍旧不清楚。最近,有研究人员调查了胆碱能神经抑制剂对AR CD4+ T辅助细胞2(Th2)的极化的影响以及潜在的调控机制。研究人员建立了体外D-U87细胞和CD4+ T细胞的共培养模型。研究发现,Th2细胞比例在来源于AR患者的CD4+ T细胞与D-U87细胞共培养后显著增加,但是在异丙托溴铵(IB)处理后减少。