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UROLOGY:膀胱癌患者的标记物测试：流行度及作用

2018-01-02 MedSci MedSci原创

urinarybladderneoplasmsinsituhybridizationfluorescencebiomarkerTumor
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应用新型的膀胱肿瘤标志物检查可能更早地发现肿瘤同时改善患者预后，但目前的应用数据有限。 研究人员试图找出膀胱癌患者应用尿标记物和泌尿系统肿瘤标记物检查与长期预后的潜在关联。

应用新型的膀胱肿瘤标志物检查可能更早地发现肿瘤同时改善患者预后，但目前的应用数据有限。 研究人员试图找出膀胱癌患者应用尿标记物和泌尿系统肿瘤标记物检查与长期预后的潜在关联。

研究人员使用2001年到2011年的SEER（监测，流行病学和最终结果）-Medicare数据库的数据来鉴定64450名膀胱癌患者，并进行UroVysion？荧光原位杂交或NMP22？或BTA Stat？测试。 然后研究人员评估了尿标记测试和尿细胞学的流行病学特点，并对进行和未进行尿标记测试的患者的特征进行卡方检验分析。 同时，使用多变量对数回归模型分析尿标记测试预测因子，并使用Cox回归分析以确定癌症特异性和总体死亡风险。

研究期间，尿标记检测率从17.8％上升到28.2％（p <0.0001）。 使用标记物的预测因素包括女性，年龄较小和Charlson评分较低。 Kaplan-Meier和Cox比例风险分析结果显示，总体和癌症特异性生存率得到提高。

结论：增加的尿标记物测试可能有助于改善癌症特异性生存并可能更早地发现恶性肿瘤。

原始出处：Vikram M. Narayan .et al.The Prevalence and Impact of Urinary Marker Testing in Patients with Bladder Cancer. UROLOGY.2018

本文系梅斯医学（MedSci）原创编译整理，转载需授权！

本文系梅斯医学（MedSci）原创编译整理，转载需授权！
本文系梅斯医学（MedSci）原创编译整理，转载需授权！
轻灵划译
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    2018-09-01 wjywjy

    #标记物#

    0

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    2018-05-25 piaojinhua

    #流行度#

    0

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    2018-01-07 zwjnj2

    好好好好学习学习

    0

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    2018-01-03 深海的鱼

    学习学习学习

    0

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    2018-01-03 chunjianf

    学习了.谢谢分享

    0

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    2018-01-03 一个字-牛

    学习了谢谢分享

    0

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    2018-01-03 doctorJiangchao

    谢谢分享.

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    2018-01-02 有备才能无患

    应用新型的膀胱肿瘤标志物检查可能更早地发现肿瘤同时改善患者预后.但目前的应用数据有限.研究人员试图找出膀胱癌患者应用尿标记物和泌尿系统肿瘤标记物检查与长期预后的潜在关联.研究人员使用2001年到2011年的SEER(监测.流行病学和最终结果)-Medicare数据库的数据来鉴定64450名膀胱癌患者.并进行UroVysion?荧光原位杂交或NMP22?或BTAStat?测试.然后研究人员评估了尿标记测试和尿细胞学的流行病学特点.并对进行和未进行尿标记测试的患者的特征进行卡方检验分析.同时.使用多变量对数回归模型分析尿标记测试预测因子.并使用Cox回归分析以确定癌症特异性和总体死亡风险.研究期间.尿标记检测率从17.8%上升到28.2%(p<0.0001).使用标记物的预测因素包括女性.年龄较小和Charlson评分较低.Kaplan-Meier和Cox比例风险分析结果显示.总体和癌症特异性生存率得到提高

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