Stroke: STX-VCS降低迟发性脑梗死风险

2020-02-18 国际循环 国际循环

迟发性脑梗死(DCI)是导致动脉瘤性蛛网膜下腔出血(aSAH)患者发病率和死亡率增加的重要因素。立体定向导管脑室-脑池造瘘术(STX-VCS)和纤溶/解痉灌洗是预防DCI的一种新方法。近期,Stroke杂志发表研究,评估在三级转诊中心未经选择的aSAH患者群体接受STX-VCS的效果。

迟发性脑梗死(DCI)是导致动脉瘤性蛛网膜下腔出血(aSAH)患者发病率和死亡率增加的重要因素。立体定向导管脑室-脑池造瘘术(STX-VCS)和纤溶/解痉灌洗是预防DCI的一种新方法。近期,Stroke杂志发表研究,评估在三级转诊中心未经选择的aSAH患者群体接受STX-VCS的效果。
 
在研究进行的7年(2012年4月至2019年4月)中,纳入收治于神经外科转诊中心的所有连续aSAH患者进行回顾性队列研究。在研究进行到中期时,将STX-VCS引入并给予DCI高危患者。我们比较了研究进行到3.5年之前和之后的aSAH人群中DCI发病率和负担、神经功能结果、高血压血管内抢救治疗情况。
 
研究共纳入436例患者,其中222例为3.5年治疗前,214例为3.5年治疗后。214例患者中57例(27%)接受了STX-VCS。接受立体定向手术的患者中出现1例(2%)硬膜下血肿。在6个月内,118例(53%)治疗前患者和139例治疗后(65%)患者(RR=0.79;95%CI:0.66~0.95)神经系统预后良好。共有40例(18.0%)治疗前患者和17例(7.9%)治疗后患者出现DCI(RR=0.68;95%CI:0.57~0.86),DCI总体积分别为8933 ml(100%)和3329 ml(36%)。治疗前和治疗后人群中分别有97例(44%)和30例(15%)出现诱导性高血压(RR=0.55;95%CI:0.46~0.65)。分别有30例治疗前患者(13.5%)和5例(2.3%)治疗后患者接受血管内抢救(RR=0.17;95%CI:0.07~0.42)。
 
这项研究提示,aSAH人群中的高危患者进行STX-VCS治疗可降低DCI发病率、负担和相关死亡率,这些获益可能源自神经功能的改善。
 
原始出处:
Roland Roelz, Jan Hendrik Schaefer, et al. Impact of Stereotactic Ventriculocisternostomy on Delayed Cerebral Infarction and Outcome After Subarachnoid Hemorrhage. Stroke. Originally published4 Dec 2019.

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    2020-02-20 karmond