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Oncogenesis：伊马替尼或可靶向治疗某些雌激素受体阳性乳腺小叶浸润癌

2018-02-14 Aries 肿瘤资讯

BCK4乳腺癌c-Kit伊马替尼
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该研究使用新的雌激素受体阳性ILC模型（BCK4）和基因表达阵列发现，BCK4细胞系和异种移植肿瘤大约200个重叠基因受到体外雌激素调节，根据通路分析显示，c-Kit通路可能成为减少雌激素诱导乳腺癌细胞增殖的靶点。

该研究使用新的雌激素受体阳性ILC模型（BCK4）和基因表达阵列发现，BCK4细胞系和异种移植肿瘤大约200个重叠基因受到体外雌激素调节，根据通路分析显示，c-Kit通路可能成为减少雌激素诱导乳腺癌细胞增殖的靶点。该研究还发现，用于治疗白血病的甲磺酸伊马替尼（格列卫）能够抑制c-Kit活性，与雌激素受体拮抗剂氟维司群（芙仕得）可以同样有效阻断雌激素对体外BCK4细胞和BCK4肿瘤的刺激。此外，使用小发夹核糖核酸（shRNA）干扰c-Kit表达，也可减少基线和雌激素诱导的体外和体内乳腺癌细胞增殖。因此，该研究首次表明，抑制c-Kit或可成为靶向治疗c-Kit阳性ILC的有效方法。

原始出处：

J. Chuck Harrell， Thomas M. Shroka，Britta M. Jacobsen.Estrogen induces c-Kit and an aggressive phenotype in a model of invasive lobular breast cancer.Oncogenesis.27 November 2017

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    2018-05-13 cy0324

    #Gene#

    0

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    2018-09-29 mjldent

    #激素受体阳性#

    0

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    2018-02-16 surilei

    #雌激素受体#

    0

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    2018-02-16 zsyan

    #Oncogene#

    0

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    2018-02-16 skhzy

    #ESI#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=2048982, encodeId=89ec2048982a0, content=<a href='/topic/show?id=4363e929ad' target=_blank style='color:#2F92EE;'>#Gene#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7929, encryptionId=4363e929ad, topicName=Gene)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=63a4277, createdName=cy0324, createdTime=Sun May 13 05:15:00 CST 2018, time=2018-05-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1980847, encodeId=80b8198084e07, content=<a href='/topic/show?id=aaf6668192d' target=_blank style='color:#2F92EE;'>#激素受体阳性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66819, encryptionId=aaf6668192d, topicName=激素受体阳性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5662228, createdName=mjldent, createdTime=Sat Sep 29 22:15:00 CST 2018, time=2018-09-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1503486, encodeId=cb22150348674, content=<a href='/topic/show?id=59d798e61f0' target=_blank style='color:#2F92EE;'>#雌激素受体#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98761, encryptionId=59d798e61f0, topicName=雌激素受体)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ae6c9649886, createdName=surilei, createdTime=Fri Feb 16 03:15:00 CST 2018, time=2018-02-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1558110, encodeId=3930155811006, content=<a href='/topic/show?id=2f1c13349e7' target=_blank style='color:#2F92EE;'>#Oncogene#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13349, encryptionId=2f1c13349e7, topicName=Oncogene)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=154614942533, createdName=zsyan, createdTime=Fri Feb 16 03:15:00 CST 2018, time=2018-02-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1588315, encodeId=b2f7158831500, content=<a href='/topic/show?id=1cb8e014e0' target=_blank style='color:#2F92EE;'>#ESI#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7014, encryptionId=1cb8e014e0, topicName=ESI)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f4f817593223, createdName=skhzy, createdTime=Fri Feb 16 03:15:00 CST 2018, time=2018-02-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=287912, encodeId=437e28e912e1, content=学习了.谢谢作者分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xJXLtMtt5B40XXuPjn9xn1rBhrM6fHLkX1hI86ZoWoPJkgDkZuJNKkBfBHOcRd1fAdezg7JlHNOokohdAp3WkI/0, createdBy=32c81964262, createdName=1e145228m78(暂无匿称), createdTime=Wed Feb 14 13:50:38 CST 2018, time=2018-02-14, status=1, ipAttribution=)]
    2018-02-14 1e145228m78(暂无匿称)

    学习了.谢谢作者分享!

    0