Gastroenterology:复发性憩室炎出血与使用血小板抑制剂有关

2018-11-11 MedSci MedSci原创

尽管临床工作中复发性憩室出血很常见,但其发病率和危险因素尚未在大样本人群中得到验证。本项研究分析了复发性憩室出血的发生率和危险因素,以及憩室出血后停止抗凝是否与缺血性卒中相关。

背景与目的
尽管临床工作中复发性憩室出血很常见,但其发病率和危险因素尚未在大样本人群中得到验证。本项研究分析了复发性憩室出血的发生率和危险因素,以及憩室出血后停止抗凝是否与缺血性卒中相关。

方法
研究人员对2000年至2016年间就诊的患者进行了一项回顾性队列研究。初始和复发性憩室出血的发生率通过出院诊断与憩室出血来统计判断。使用针对人口统计学,合并症和药物使用的调整Cox比例风险回归计算与抗凝血剂或血小板聚集抑制剂相关的继发性憩室出血的风险比。

结果
在所分析的队列中,有14925名患者出现了原发性憩室出血;这些患者中有1368人发生了第二次发作。原发性和第二次憩室出血的非标准化发生率为每10万人年10.9(95%[CI] 10.7-11.0)和每10万人年3625.6(95%CI 3436.0-3823.0)。血小板聚集抑制剂与憩室出血的第二次发作相关(OR:1.47; 95%CI 1.15-1.88),而所有类别的抗凝剂均没有相关性。在具有潜在卒中风险的患者中,那些在憩室出血后停止抗凝治疗的患者缺血性卒中风险增加(OR:1.93; 95%CI 1.17-3.19)。

结论
在这项回顾性队列研究中,血小板聚集抑制剂与复发性憩室出血有关。停止抗凝治疗与缺血性中风的危害增加有关。

原始出处:

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    2019-01-11 许安
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    2019-03-22 jklm09
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    2018-11-13 zutt
  9. [GetPortalCommentsPageByObjectIdResponse(id=1909744, encodeId=49451909e444f, content=<a href='/topic/show?id=8f1f42518d8' target=_blank style='color:#2F92EE;'>#复发性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42518, encryptionId=8f1f42518d8, topicName=复发性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=hb2008ye, createdTime=Thu Sep 26 05:01:00 CST 2019, time=2019-09-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2072354, encodeId=156c20e235454, content=<a href='/topic/show?id=9d4ee84647' target=_blank style='color:#2F92EE;'>#GAS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7846, encryptionId=9d4ee84647, topicName=GAS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e2dd327, createdName=许安, createdTime=Fri Jan 11 08:01:00 CST 2019, time=2019-01-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1851835, encodeId=35e8185183551, content=<a href='/topic/show?id=f0a254918f0' target=_blank style='color:#2F92EE;'>#抑制剂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54918, encryptionId=f0a254918f0, topicName=抑制剂)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=44a360, createdName=jklm09, createdTime=Fri Mar 22 09:01:00 CST 2019, time=2019-03-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1711710, encodeId=34271e11710dd, content=<a href='/topic/show?id=9a1c289680' target=_blank style='color:#2F92EE;'>#AST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2896, encryptionId=9a1c289680, topicName=AST)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b9831894722, createdName=ms24272190615788285182, createdTime=Sat Mar 02 10:01:00 CST 2019, time=2019-03-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2064536, encodeId=5dc9206453638, content=<a href='/topic/show?id=94ffe853a7' target=_blank style='color:#2F92EE;'>#Gastroenterol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7853, encryptionId=94ffe853a7, topicName=Gastroenterol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0bed488, createdName=jktdtl, createdTime=Tue Sep 10 09:01:00 CST 2019, time=2019-09-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1391445, encodeId=d6de1391445a4, content=<a href='/topic/show?id=b5be53e91fc' target=_blank style='color:#2F92EE;'>#憩室炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53791, encryptionId=b5be53e91fc, topicName=憩室炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d4902500082, createdName=1249883fm12暂无昵称, createdTime=Tue Nov 13 12:01:00 CST 2018, time=2018-11-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1504519, encodeId=27d5150451976, content=<a href='/topic/show?id=7730e85412' target=_blank style='color:#2F92EE;'>#Gastroenterology#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7854, encryptionId=7730e85412, topicName=Gastroenterology)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=医者仁心, createdTime=Tue Nov 13 12:01:00 CST 2018, time=2018-11-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1522731, encodeId=c6881522e3186, content=<a href='/topic/show?id=14d853e8918' target=_blank style='color:#2F92EE;'>#憩室#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53789, encryptionId=14d853e8918, topicName=憩室)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=33b211483971, createdName=zutt, createdTime=Tue Nov 13 12:01:00 CST 2018, time=2018-11-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=352342, encodeId=4ea4352342a4, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Mon Nov 12 07:46:11 CST 2018, time=2018-11-12, status=1, ipAttribution=)]
    2018-11-12 1209e435m98(暂无昵称)

    学习了,谢谢分享

    0

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