Biomater Sci:眼睑体内重建的仿生眼肌 - 结膜双相支架

2019-06-29 MedSci 网络

浙江大学医学院附属第二医院眼科的Xu P和Gao Q等人近日在Biomater Sci杂志上发表了一项重要的研究论文,他们构建了结膜双相支架,可以在帮助眼睑在体内重建。

浙江大学医学院附属第二医院眼科的Xu P和Gao Q等人近日在Biomater Sci杂志上发表了一项重要的研究论文,他们构建了结膜双相支架,可以在帮助眼睑在体内重建。

t板替代物的常规3D多孔支架常引起角膜刺激和结膜粘液渗出,甚至导致失明和瘢痕性眼睑畸形等。在该研究中,研究者将厚度为240μm、466μm和724μm的胶原/壳聚糖(Col / CS)海绵复合到聚甲基丙烯酸-2-羟乙酯(PPF-HEMA)聚合物(丙烯富马酸酯)网络上以获得相应的双相支架,模拟眼睑后部薄层的自然解剖结构。

这三种支架呈现多孔结构,孔隙率约为90%,可以很好地模拟弹性模量、适宜的降解速率和良好的生物相容性。通过不同厚度的Col / CS海绵复合,调节支架的机械性质来有效的感知细胞,诱导不同的细胞行为,例如细胞增殖、分布和分层。他们在兔tarso-conjunctival缺损模型中,移植双相支架可以促进结膜功能性再生。

因此,双相复合支架可能是眼结膜修复的具有重要潜力的替代品。

原文出处:

Xu, P., et al., A biomimetic tarso-conjunctival biphasic scaffold for eyelid reconstruction in vivo. Biomater Sci, 2019.

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    2020-05-07 zhangbaojun
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    2020-04-06 sunylz
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    2019-06-29 医者仁心5538

    学习了

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